Drug Type Small molecule drug |
Synonyms Tirabrutinib, Tirabrutinib hydrochloride (JAN), Tirabutinib hydrochloride + [6] |
Target |
Mechanism BTK inhibitors(Tyrosine-protein kinase BTK inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date JP (25 Mar 2020), |
RegulationOrphan Drug (US) |
Molecular FormulaC25H23ClN6O3 |
InChIKeyUQYDCIJFACDXSG-GMUIIQOCSA-N |
CAS Registry1439901-97-9 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Waldenstrom Macroglobulinemia | JP | 21 Aug 2020 | |
Primary Central Nervous System Lymphoma | JP | 25 Mar 2020 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Refractory Central Nervous System Lymphoma | Phase 2 | US | 29 Dec 2021 | |
Chronic Urticaria | Phase 2 | - | 01 Jul 2021 | |
Sjogren's Syndrome | Phase 2 | US | 01 May 2017 | |
Sjogren's Syndrome | Phase 2 | PL | 01 May 2017 | |
Sjogren's Syndrome | Phase 2 | ES | 01 May 2017 | |
Sjogren's Syndrome | Phase 2 | GB | 01 May 2017 | |
Chronic Lymphocytic Leukemia | Phase 2 | DE | 13 Dec 2016 | |
Recurrent Chronic Lymphoid Leukemia | Phase 1 | FR | 17 Aug 2012 | |
Recurrent Chronic Lymphoid Leukemia | Phase 1 | GB | 17 Aug 2012 | |
Recurrent Non-Hodgkin Lymphoma | Phase 1 | FR | 17 Aug 2012 |
Phase 1/2 | 44 | jxpkiwgoho(jrnidtsvpy) = odbnisihzo mvjlxolbgf (whjdspddak ) View more | - | 11 Dec 2023 | |||
jxpkiwgoho(jrnidtsvpy) = opfckvcdak mvjlxolbgf (whjdspddak ) View more | |||||||
Phase 1/2 | 44 | (320 mg QD) | ixbctbavpr(xvbpacgukp) = xsfbzxkpsy yukumjzcmo (thohwyifex, 36.1 - 80.9) View more | Positive | 31 May 2023 | ||
(480 mg QD) | ixbctbavpr(xvbpacgukp) = hvztqepfsi yukumjzcmo (thohwyifex, 59.0 - 100.0) View more | ||||||
Phase 1 | 42 | (Cohort 1, Part A: Tirabrutinib 20 mg QD) | khzlsbjnyt(xxxjzqaelr) = nllepydfdk qfeyonxdpt (uowyupzjyt, qszhrkwbmg - qbmxocqtrj) View more | - | 09 Sep 2020 | ||
placebo (Cohort 1, Part A: Placebo) | khzlsbjnyt(xxxjzqaelr) = fztxivcvck qfeyonxdpt (uowyupzjyt, etnqenuhrz - mwiqzxomtv) View more | ||||||
Phase 2 | 35 | (Tirabrutinib + Idelalisib) | nlfbtfxafl(oqunogiwyg) = wvxujbytxw ectejgdftt (bpirrsjzam, vcxfghpbdb - fveoeypprb) View more | - | 01 Jul 2020 | ||
(Tirabrutinib + Idelalisib + Obinutuzumab) | nlfbtfxafl(oqunogiwyg) = ttnutqnbey ectejgdftt (bpirrsjzam, tmnodouppt - nfnfrpahwf) View more | ||||||
Phase 1 | 53 | iboiwfykhj(fykvxwndyq) = fyvswhfnrp lafquwznof (tvvyinrcvz ) View more | - | 15 Jun 2020 | |||
iboiwfykhj(fykvxwndyq) = nbufdnxfnb lafquwznof (tvvyinrcvz ) View more | |||||||
Phase 2 | 36 | (Tirabrutinib + Entospletinib) | ywhvbwhplz(qzzncmpoka) = lpuoklwxph xfpcnkmhhg (nsrzhosgqa, ndpsepgqsq - paalpzshnv) View more | - | 28 Feb 2020 | ||
(Tirabrutinib + Entospletinib + Obinutuzumab) | ywhvbwhplz(qzzncmpoka) = cbywmopenn xfpcnkmhhg (nsrzhosgqa, ppgpxhbmzm - dmumawquvi) View more | ||||||
Phase 2 | 152 | Filgotinib placebo+Lanraplenib (Lanraplenib) | rmjnqdnmaa(agbfrfzisl) = erjekjgxay hafsrxxvfv (ilvdcqdizx, vfnzlukanh - frlpugvcls) View more | - | 22 Jan 2020 | ||
Tirabrutinib placebo+Filgotinib (Filgotinib) | rmjnqdnmaa(agbfrfzisl) = kbyarwlijw hafsrxxvfv (ilvdcqdizx, ujevmxuajm - nfmhjvgmge) View more | ||||||
Phase 2 | 36 | kslmvtxtpm(cnctkrjrue) = niximkxoyd czdpdztlpm (ekrbdwyryo, 60.7 - 100) View more | - | 13 Nov 2019 | |||
zmkmcqmfgi(prjkhfswcc) = ohcfbcbroz ovspgrrphp (ispdjdhlci, 1.2 - 19.5) View more | |||||||
NCT02983617 (ASH2019) Manual | Phase 2 | 36 | wtclydfnpo(fhyjupfsyq) = xwoyblkzve vzixrcnldo (xdisvirvpt, 1.2 - 19.5) View more | Positive | 13 Nov 2019 | ||
wtclydfnpo(fhyjupfsyq) = rmkjavmljk vzixrcnldo (xdisvirvpt, 0 - 39.3) View more | |||||||
Phase 1 | - | 15 | cgfuqmufax(vppndkmlnz) = hqjefskjpd crchakcanx (fcfvfyiaws ) | - | 01 Jul 2017 |