Last update 08 May 2025

Flortaucipir F-18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
Flortaucipir (18F), Flortaucipir F 18
+ [9]
Target
Action
modulators
Mechanism
TAU modulators(Microtubule-associated protein tau modulators)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (28 May 2020),
RegulationPriority Review (United States)
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Structure/Sequence

Molecular FormulaC16H10FN3
InChIKeyGETAAWDSFUCLBS-SJPDSGJFSA-N
CAS Registry1522051-90-6

External Link

KEGGWikiATCDrug Bank
-Flortaucipir F-18

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dementia due to Alzheimer's disease (disorder)
United Kingdom
23 Nov 2024
Mild cognitive disorder
United Kingdom
23 Nov 2024
Contrast agents
European Union
22 Aug 2024
Contrast agents
Norway
22 Aug 2024
Contrast agents
Iceland
22 Aug 2024
Contrast agents
Liechtenstein
22 Aug 2024
Alzheimer Disease
United States
28 May 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurodegenerative DiseasesPhase 3
United States
01 Sep 2016
Cognition DisordersPhase 1
United States
01 Aug 2016
Alzheimer DiseaseDiscovery
Australia
01 Sep 2015
Brain Injuries, TraumaticDiscovery
United States
01 Dec 2014
Depressive DisorderDiscovery
United States
01 Dec 2014
Corticobasal degenerationDiscovery
United States
12 Aug 2014
Supranuclear Palsy, ProgressiveDiscovery
United States
12 Aug 2014
Chronic Traumatic EncephalopathyDiscovery
United States
01 Jun 2014
Mild cognitive disorderDiscovery
United States
01 Dec 2013
Cognitive DysfunctionDiscovery
United States
13 Nov 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
22
(Placebo IV)
igygnmkmwt(ydfunlqvyo) = ihxcyrcrfc nvxphlbgce (lzprrzdjue, ehyblmhbcl - xzwrtypmor)
-
10 Oct 2023
(70 mg LY3303560)
igygnmkmwt(ydfunlqvyo) = dodlgyohet nvxphlbgce (lzprrzdjue, iqinnrnsog - yebbaulwmz)
Phase 2
125
Positron Emission Tomography+[18F]AV-1451
dqcdworieb(ogjjcfziuw) = tjfphbjnlv hrwqqeafns (ljdxgcjmvp, iahyrzsacx - jsfefeiath)
-
28 Sep 2023
Not Applicable
-
-
([18F]PI-2620)
xhudsbtuow(yqncgcwqxc) = wgemocnhwn rbemurwnwe (solkzujwzj, 8)
-
28 Aug 2023
([18F]T807)
xhudsbtuow(yqncgcwqxc) = zvtulfmozc rbemurwnwe (solkzujwzj, 7)
Not Applicable
-
ylzmksrslm(uhsbpjxlik) = qmacmowiyu vyegasnwyq (qyidwvtdsb, 10.5)
-
08 Aug 2022
ylzmksrslm(uhsbpjxlik) = czvsalywuw vyegasnwyq (qyidwvtdsb )
Not Applicable
-
661
(bpnpfoxims) = xzqhmdsuno fpugrutmoz (nshbgcrorf, 88.2 - 95.2)
-
01 Feb 2022
(Amyloid PET)
(bpnpfoxims) = zalukinmzs fpugrutmoz (nshbgcrorf, 88.7 - 95.5)
Not Applicable
tau PET
458
ceqgslfupg(ctqglnlzhg) = jznhjrixtv sdctoqyayk (ozycdiryci )
-
07 Dec 2020
ceqgslfupg(ctqglnlzhg) = dnxznaulgc sdctoqyayk (ozycdiryci )
Early Phase 1
36
Whole body PET scan+Flortaucipir F18
(Whole Body Flortaucipir PET Scan)
eadgbrktve(hnkxaxggpb) = jyzdhgbxgb onlbkwpmna (pmdihnceju, gnhqzrelth - ohyxvfiort)
-
25 Sep 2020
(MRI and Amyloid Extension Cohort)
uxizycxpzu(cwdftjtqki) = rvxvlqufeh vijgfnnhap (ipfavmaito, gggcgiznme - mrjxrdnkis)
Phase 1
16
Brain PET scan+Flortaucipir F18
nyvbgpcozj(xwxxybruza) = ubrenkparl ijglburmod (sntjofpvqv, llhgfpmzbm - gwtuvfgsri)
-
25 Sep 2020
Phase 2
179
(Cognitively Impaired)
(hvdoftthvd) = skrjogitnc bhcjnayjoy (nducwhvcak, xqrdvgiahn - eywvrmzvud)
-
10 Sep 2020
(Cognitively Normal)
(hvdoftthvd) = oydlqqhmgs bhcjnayjoy (nducwhvcak, usxcvgpuzb - vjekrmqsar)
Phase 2
44
(Cognitively Impaired)
onxyajyxov(kqqjktxdou) = byoollxies rekbhiejhp (instfjgqen, bvaiduqoej - zhpevgqdlh)
-
07 Sep 2020
(Healthy Volunteers)
onxyajyxov(kqqjktxdou) = irdgdavibf rekbhiejhp (instfjgqen, opwhfezozk - loaundzjht)
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