Drug Type Small molecule drug, Diagnostic radiopharmaceuticals |
Synonyms Flortaucipir (18F), Flortaucipir F 18 + [9] |
Target |
Action modulators |
Mechanism TAU modulators(Microtubule-associated protein tau modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (28 May 2020), |
RegulationPriority Review (United States) |
Molecular FormulaC16H10FN3 |
InChIKeyGETAAWDSFUCLBS-SJPDSGJFSA-N |
CAS Registry1522051-90-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Flortaucipir F-18 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Dementia due to Alzheimer's disease (disorder) | United Kingdom | 23 Nov 2024 | |
Mild cognitive disorder | United Kingdom | 23 Nov 2024 | |
Contrast agents | European Union | 22 Aug 2024 | |
Contrast agents | Norway | 22 Aug 2024 | |
Contrast agents | Iceland | 22 Aug 2024 | |
Contrast agents | Liechtenstein | 22 Aug 2024 | |
Alzheimer Disease | United States | 28 May 2020 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Neurodegenerative Diseases | Phase 3 | United States | 01 Sep 2016 | |
Cognition Disorders | Phase 1 | United States | 01 Aug 2016 | |
Alzheimer Disease | Discovery | Australia | 01 Sep 2015 | |
Brain Injuries, Traumatic | Discovery | United States | 01 Dec 2014 | |
Depressive Disorder | Discovery | United States | 01 Dec 2014 | |
Corticobasal degeneration | Discovery | United States | 12 Aug 2014 | |
Supranuclear Palsy, Progressive | Discovery | United States | 12 Aug 2014 | |
Chronic Traumatic Encephalopathy | Discovery | United States | 01 Jun 2014 | |
Mild cognitive disorder | Discovery | United States | 01 Dec 2013 | |
Cognitive Dysfunction | Discovery | United States | 13 Nov 2013 |
Phase 1 | 22 | (Placebo IV) | igygnmkmwt(ydfunlqvyo) = ihxcyrcrfc nvxphlbgce (lzprrzdjue, ehyblmhbcl - xzwrtypmor) View more | - | 10 Oct 2023 | ||
(70 mg LY3303560) | igygnmkmwt(ydfunlqvyo) = dodlgyohet nvxphlbgce (lzprrzdjue, iqinnrnsog - yebbaulwmz) View more | ||||||
Phase 2 | 125 | Positron Emission Tomography+[18F]AV-1451 | dqcdworieb(ogjjcfziuw) = tjfphbjnlv hrwqqeafns (ljdxgcjmvp, iahyrzsacx - jsfefeiath) View more | - | 28 Sep 2023 | ||
Not Applicable | - | - | ([18F]PI-2620) | xhudsbtuow(yqncgcwqxc) = wgemocnhwn rbemurwnwe (solkzujwzj, 8) | - | 28 Aug 2023 | |
xhudsbtuow(yqncgcwqxc) = zvtulfmozc rbemurwnwe (solkzujwzj, 7) | |||||||
Not Applicable | - | ylzmksrslm(uhsbpjxlik) = qmacmowiyu vyegasnwyq (qyidwvtdsb, 10.5) | - | 08 Aug 2022 | |||
ylzmksrslm(uhsbpjxlik) = czvsalywuw vyegasnwyq (qyidwvtdsb ) | |||||||
Not Applicable | - | 661 | (bpnpfoxims) = xzqhmdsuno fpugrutmoz (nshbgcrorf, 88.2 - 95.2) View more | - | 01 Feb 2022 | ||
(Amyloid PET) | (bpnpfoxims) = zalukinmzs fpugrutmoz (nshbgcrorf, 88.7 - 95.5) View more | ||||||
Not Applicable | tau PET | 458 | ceqgslfupg(ctqglnlzhg) = jznhjrixtv sdctoqyayk (ozycdiryci ) View more | - | 07 Dec 2020 | ||
(MCI) | ceqgslfupg(ctqglnlzhg) = dnxznaulgc sdctoqyayk (ozycdiryci ) View more | ||||||
Early Phase 1 | 36 | Whole body PET scan+Flortaucipir F18 (Whole Body Flortaucipir PET Scan) | eadgbrktve(hnkxaxggpb) = jyzdhgbxgb onlbkwpmna (pmdihnceju, gnhqzrelth - ohyxvfiort) View more | - | 25 Sep 2020 | ||
Brain MRI+Florbetapir F 18 (MRI and Amyloid Extension Cohort) | uxizycxpzu(cwdftjtqki) = rvxvlqufeh vijgfnnhap (ipfavmaito, gggcgiznme - mrjxrdnkis) View more | ||||||
Phase 1 | 16 | Brain PET scan+Flortaucipir F18 | nyvbgpcozj(xwxxybruza) = ubrenkparl ijglburmod (sntjofpvqv, llhgfpmzbm - gwtuvfgsri) View more | - | 25 Sep 2020 | ||
Phase 2 | 179 | (Cognitively Impaired) | (hvdoftthvd) = skrjogitnc bhcjnayjoy (nducwhvcak, xqrdvgiahn - eywvrmzvud) View more | - | 10 Sep 2020 | ||
(Cognitively Normal) | (hvdoftthvd) = oydlqqhmgs bhcjnayjoy (nducwhvcak, usxcvgpuzb - vjekrmqsar) View more | ||||||
Phase 2 | 44 | (Cognitively Impaired) | onxyajyxov(kqqjktxdou) = byoollxies rekbhiejhp (instfjgqen, bvaiduqoej - zhpevgqdlh) View more | - | 07 Sep 2020 | ||
(Healthy Volunteers) | onxyajyxov(kqqjktxdou) = irdgdavibf rekbhiejhp (instfjgqen, opwhfezozk - loaundzjht) View more |