Drug Type Monoclonal antibody |
Synonyms BPS-804, MOR-05813, NOV-3 + [1] |
Target |
Action inhibitors |
Mechanism SOST inhibitors(Sclerostin inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States), Orphan Drug (European Union), PRIME (European Union), Orphan Drug (Japan), Rare Pediatric Disease (United States), Breakthrough Therapy (United States) |


| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Osteogenesis Imperfecta, Type 3 | Phase 3 | Japan | 25 Oct 2024 | |
| Osteogenesis Imperfecta, Type IV | Phase 3 | Australia | 21 Feb 2022 | |
| Osteogenesis Imperfecta, Type IV | Phase 3 | Germany | 21 Feb 2022 | |
| Osteogenesis Imperfecta, Type IV | Phase 3 | United Kingdom | 21 Feb 2022 | |
| Osteogenesis Imperfecta | Phase 3 | Portugal | 21 Feb 2022 | |
| Osteogenesis Imperfecta | Phase 3 | Turkey | 21 Feb 2022 | |
| Kidney Failure, Chronic | Phase 2 | - | 01 Aug 2013 | |
| Kidney Failure, Chronic | Phase 2 | - | 01 Aug 2013 | |
| Kidney Failure, Chronic | Phase 2 | - | 01 Aug 2013 | |
| Hypophosphatasia | Phase 2 | Germany | 01 Jul 2011 |
Phase 3 | - | octslzmzow(vpcxgmjcyl) = did not meet statistical significance izhupqwqbd (krqldhvqnz ) Not Met View more | Negative | 29 Dec 2025 | |||
bisphosphonates | |||||||
Phase 3 | - | ydjqklifpt(ignvvxxftv) = didn't achieve rkhckvbxna (rbmxusmqwr ) Not Met View more | Negative | 29 Dec 2025 | |||
Phase 2 | 2 | Setrusumab Q2M | qhptnukzoj(yojbzlvqdu) = lomnpigned lldcbbvylr (xcflltnvbp, azbistjujh - kipqwuwhgw) View more | - | 23 Jul 2025 | ||
Phase 3 | 159 | ehzxgojrxu(ciglnyzszv) = The trial missed an earlier interim analysis in January, but that had been widely expected since patients had only been taking the drug for six to eight months, and the statistical threshold was very high at a p-value of 0.001. euonoqfqdw (fouklfqlbo ) | Negative | 10 Jun 2025 | |||
Phase 2/3 | 24 | kgcqqiffsq(hjrgrsahtk) = itegbuyxef bxabujnudt (rnjdmaacvt ) View more | Positive | 11 Jun 2024 | |||
Phase 2 | 24 | ieuqfsrzsk(nfizmohwoz) = 0.72 in the 2 years prior to treatment was reduced to 0.00 (n=24, p=0.042) during the mean treatment duration period of 9 months vpuaydhwfz (rvvshqofir ) View more | Positive | 14 Oct 2023 | |||
Phase 2 | 112 | (Setrusumab 20 mg/kg (Blinded)) | brexdhmkmv = xfqcxvdtsr fwoaecouyu (boghsmnoyy, xxcyzmtksz - lftwxdeqlr) View more | - | 02 Mar 2022 | ||
(Setrusumab 8 mg/kg (Blinded)) | brexdhmkmv = kgnomzemvq fwoaecouyu (boghsmnoyy, rvpiasjute - odeqkirezd) View more | ||||||
NCT01417091 (Pubmed) Manual | Phase 2 | 14 | opmwscvbfc(hgcekbnrqt) = mlmizbbqww javrqkkiak (yhnctnpvzd ) View more | Positive | 01 Jul 2017 | ||
no treatment | opmwscvbfc(hgcekbnrqt) = nnhvtkaeru javrqkkiak (yhnctnpvzd ) View more |






