Comparison of the effect of Myoinositol with the control group on the outcomes of assisted reproductive treatments in patients with polycystic ovary syndrome

Start Date22 Aug 2024

Sponsor / Collaborator

Tehran University of Medical Sciences

CTRI/2024/08/072191 / Not yet recruitingNot ApplicableIIT

Effects of myoinositol supplementation on seizure frequency in person with drug resistant epilepsy:A double blind randomized N-of-1 trial - Nil

Start Date21 Aug 2024

Sponsor / Collaborator-

RBR-557c2cz / Not yet recruitingPhase 3IIT

Myoinositol as adjuvant therapy in patients with Polycystic Ovary Syndrome undergoing Assisted Reproduction procedures

Start Date01 Aug 2024

Sponsor / Collaborator-

100 Clinical Results associated with Inositol

100 Translational Medicine associated with Inositol

100 Patents (Medical) associated with Inositol

1,784

Literatures (Medical) associated with Inositol

01 Jan 2025·JOURNAL OF HAZARDOUS MATERIALS

Heavy metal exposure and its effects on APOC3, CFAI, and ZA2G

Article

Author: Mun, Sora ; Heo, Min ; Hong, Young-Seoub ; Kim, Woo Jin ; Kim, Nam-Eun ; Shin, Hyeongyu ; Kim, Jung-Woong ; Park, Kyungtaek ; Kim, Chul-Hong ; Yoo, Hyun Ju ; Jin, Heejin ; Do, Ah Ra ; Kang, Hee-Gyoo ; Cho, Yong Min ; Kim, Mi Jeong ; Kim, Jeeyoung ; Won, Sungho

Despite increasing heavy metal pollution, traditional epidemiology often fails to link exposure to health outcomes. This study used multi-omics to investigate associations between heavy metal exposure and health. Blood and urine samples from 294 participants in heavy metal-exposed and control areas were analyzed, revealing key biomarkers. Meta P analysis revealed consistent trends in apolipoprotein C3 (APOC3) expression, and mediation analysis showed significant effects of APOC3 and zinc-alpha-2-glycoprotein (ZA2G) on metabolites: the mediating effect of APOC3 from blood cadmium to serotonin was 0.023 (P < 0.001) and that to 3-phosphoglyceric acid (3PG) was 0.0125 (P = 0.002). Mendelian randomization confirmed the positive impact of APOC3 and Complement Factor I (CFAI) and the negative effect of ZA2G on metabolites, with apolipoprotein H (APOH) methylation significantly altering APOC3 (β = -0.22, P = 0.017), CFAI (β = 0.176, P = 0.035), and ZA2G (β = 0.139, P = 0.048) protein levels. Liver function variables, including albumin, total protein, calcium, and lactate dehydrogenase, correlated with 3PG and serotonin levels in the exposed areas. Sex-specific analysis showed that men exhibited stronger compensatory mechanisms via CFAI and myo-inositol, while women's greater vulnerability to heavy metal exposure highlighted the need for targeted interventions. These findings suggest APOH methylation affects APOC3, CFAI, and ZA2G levels, elevating 3PG, inosine monophosphate, and serotonin levels and harming liver function via lipolysis, supporting the use of these markers in health monitoring, therapies, and policies to limit heavy metal risks.

01 Jan 2025·POULTRY SCIENCE

Effects of myo-inositol supplementation in the diet on myo-inositol concentrations in the intestine, blood, eggs, and excreta of laying hens

Article

Author: Huber, Korinna ; Stefanski, Volker ; Schmucker, Sonja ; Camarinha-Silva, Amélia ; Föller, Michael ; Seifert, Jana ; Wimmers, Klaus ; Bennewitz, Jörn ; Oster, Michael ; Ponsuksili, Siriluck ; Feger, Martina ; Hanauska, Anna ; Sommerfeld, Vera ; Rodehutscord, Markus

The objectives of this study were to investigate whether an increased dietary myo-inositol (MI) supply translates into changes in MI concentrations and endogenous mucosal phosphatase activities in the intestine of laying hens and whether different laying hen strains respond differently to MI supplementation. The diets were corn-soybean meal-based and supplemented without (MI0) or with 1 (MI1), 2 (MI2), or 3 (MI3) g MI/kg feed. Ten hens per strain (Lohmann Brown-classic (LB) and Lohmann LSL-classic (LSL)) and diet were sacrificed at the age of 30 wk following a 4-wk stay in a metabolic unit. The blood plasma, digesta of the duodenum+jejunum and distal ileum, mucosa of the duodenum, and eggs were collected at wk 30. The concentration of MI in the blood plasma was increased by MI supplementation (P < 0.001); however, that of MI3 did not further increase compared with MI2. The concentration of MI in the duodenum+jejunum and ileum increased steadily (P < 0.001). The MI concentration in the duodenum+jejunum was higher in LB than in LSL hens (P = 0.017). The MI concentration in egg yolk was increased by MI supplementation (P < 0.001) and was higher in LB than in LSL hens (P = 0.015). Strain or diet did not affect mucosal phosphatase activity. Myo-inositol flow at the terminal ileum and postileal disappearance increased with each increment in MI supplementation (P < 0.001) and was higher in LB than in LSL hens (P ≤ 0.041). Regression analysis indicated that, on average, 84% of supplemented MI was retained in the body or metabolized and excreted in a different form. Based on the measured MI concentrations in the blood and eggs, dietary MI was not completely absorbed in the small intestine and, to a different extent, in the two laying hen strains. A higher dietary MI supply was followed by higher intestinal absorption or metabolism by microorganisms. The fate of supplemented MI and its relevance to birds warrant further research.

31 Dec 2024·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome

Review

Author: Lete, Iñaki ; Martínez, Ainara ; Lasaga, Irene ; Centurión, Eva ; Vesga, Amaia

In this article, we present a narrative review on the use of inositol in the treatment of polycystic ovary syndrome (PCOS). Of the different inositols that exist, only myo-inositol (MYO) and D-chiro inositol (DCI) have been studied in the treatment of PCOS. The results of the studies show that there is insufficient or controversial evidence to recommend the use of DCI alone, while MYO alone shows positive results and, above all, the MYO/DCI combination is effective when used at a ratio of at least 40:1, but there is enough rationale to further study ratios such as 66:1 to 100:1 as other possible effective combinations.

News (Medical) associated with Inositol

17 Oct 2024

·www.prnewswire.com

Nikon Small World Competition Celebrates 50 Years with Groundbreaking Image of Brain Tumor Cells

Celebrating its golden anniversary, Nikon Small World honors a stunning photo of brain tumor cell structures, advancing our understanding of neurodegenerative diseases. MELVILLE, N.Y., Oct. 17, 2024 /PRNewswire/ -- Nikon Instruments Inc. today announced the winners of the 50th annual Nikon Small World Photomicrography Competition, celebrating five decades of excellence in microscopy and digital imaging. This year's first place prize was awarded to Dr. Bruno Cisterna, with assistance from Dr. Eric Vitriol of Augusta University, for his groundbreaking image of differentiated mouse brain tumor cells, highlighting the actin cytoskeleton, microtubules, and nuclei. This image reveals how disruptions in the cell's cytoskeleton – the structural framework and "highways" known as microtubules – can lead to diseases like Alzheimer's and ALS. Continue Reading Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Dr. Cisterna's research revealed that profilin 1 (PFN1), a protein crucial for building the cell's structure, plays a key role in maintaining the microtubule highways essential for cellular transport. When PFN1 or related processes are disrupted, these highways can malfunction, leading to cellular damage similar to what is observed in neurodegenerative diseases. "One of the main problems with neurodegenerative diseases is that we don't fully understand what causes them," said Dr. Cisterna. "To develop effective treatments, we need to figure out the basics first. Our research is crucial for uncovering this knowledge and ultimately finding a cure. Differentiated cells could be used to study how mutations or toxic proteins that cause Alzheimer's or ALS alter neuronal morphology, as well as to screen potential drugs or gene therapies aimed at protecting neurons or restoring their function." His patience and determination were crucial in capturing his image. "I spent about three months perfecting the staining process to ensure clear visibility of the cells. After allowing five days for the cells to differentiate, I had to find the right field of view where the differentiated and non-differentiated cells interacted. This took about three hours of precise observation under the microscope to capture the right moment, involving many attempts and countless hours of work to get it just right." The hard work behind this discovery underscores its significance, bringing researchers closer to answers that could potentially transform millions of lives. "After three years of research, we finally published our findings four months ago in the Journal of Cell Biology, and there's still more work to be done," said Dr. Cisterna. "I'm deeply passionate about scientific imaging; I've been following the Nikon Small World contest for about 15 years. It's an incredible contest that highlights the beauty of photomicrography but also inspires continued exploration and innovation in the field." Eric Flem, Senior Manager, CRM and Communications at Nikon Instruments, shares a similar perspective on the competition. "At 50 years, Nikon Small World is more than just an imaging competition – it's become a gallery that pays tribute to the extraordinary individuals who make it possible. They are the driving force behind this event, masterfully blending science and art to reveal the wonders of the microscopic world and what we can learn from it to the public." He went on to add, "Sometimes, we overlook the tiny details of the world around us. Nikon Small World serves as a reminder to pause, appreciate the power and beauty of the little things, and to cultivate a deeper curiosity to explore and question." Second place was awarded to Dr. Marcel Clemens for his image of an electrical arc between a pin and a wire, produced by applying a potential difference of 10,000 volts. Third place was awarded to Chris Romaine for his image of a cannabis plant leaf. The bulbous structures are trichomes, or hair-like plant appendages, and the bubbles inside are cannabinoid vesicles, fluid-filled, blister-like structures. In total, Nikon Small World recognized 87 photos out of thousands of entries from scientists and artists across the globe. The 2024 judging panel included: Adrian Coakley, Director of Photography at National Geographic Books Michelle S. Itano, Ph.D., Assistant Professor of Cell Biology and Physiology and Director of the Neuroscience Microscopy Core at the University of North Carolina at Chapel Hill Emily Petersen, Photography Managing Editor at Science Magazine Clare Waterman, Ph.D., Cell Biologist and Member of the National Academy of Sciences Jennifer C. Waters, Ph.D., Director of the Core for Imaging Technology & Education at Harvard Medical School Samantha Yammine, Ph.D., Neuroscientist and Science Communicator For additional information, please visit , or follow the conversation on Facebook, Twitter @NikonSmallWorld and Instagram @NikonInstruments. NIKON SMALL WORLD WINNERS 1st Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Super-Resolution 100X (Objective Lens Magnification) 2nd Place Dr. Marcel Clemens Verona, Veneto, Italy Electrical arc between a pin and a wire Image stacking for the pin and wire combined with long exposure for the electrical arcs 10X (Objective Lens Magnification) 3rd Place Chris Romaine Kandid Kush Port Townsend, Washington, USA Leaf of a cannabis plant. The bulbous glands are trichomes. The bubbles inside are cannabinoid vesicles. Image Stacking 20X (Objective Lens Magnification) 4th Place Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Section of a small intestine of a mouse Fluorescence 10X (Objective Lens Magnification) 5th Place Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Cluster of octopus (Octopus hummelincki) eggs Darkfield, Stereomicroscopy, Focus Stacking 3X (Objective Lens Magnification) 6th Place Henri Koskinen Helsinki University Helsinki, Uudenmaan lääni, Finland Slime mold (Cribraria cancellata) Image Stacking, Polarized Light, Reflected Light 10X (Objective Lens Magnification) 7th Place Gerhard Vlcek Maria Enzersdorf, Austria Cross section of European beach grass (Ammophila arenaria) leaf Brightfield, Image Stacking 10X (Objective Lens Magnification) 8th Place Stephanie Huang Victoria University of Wellington School of Biological Sciences; School of Psychology Wellington, New Zealand A neuron densely covered in dendritic spines from the striatum of an adult rat brain Confocal, Deconvolution, Image Stacking 60X (Objective Lens Magnification) 9th Place John-Oliver Dum Medienbunker Produktion Bendorf, Rheinland Pfalz, Germany Pollen in a garden spider (Araneus) web Image Stacking 20X (Objective Lens Magnification) 10th Place Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of black truffle (Tuber melanosporum) Confocal 63X (Objective Lens Magnification) 11th Place Dr. Ferenc Halmos Bánd, Veszprém, Hungary Slime mold on a rotten twig with water droplets Image Stacking 0.7X - 4.5X (Objective Lens Magnification) 12th Place Daniel Knop Oberzent-Airlenbach, Hessen, Germany Wing scales of a butterfly (Papilio ulysses) on a medical syringe needle Image Stacking 20X (Objective Lens Magnification) 13th Place Paweł Błachowicz Bedlno, Świętokrzyskie, Poland Eyes of green crab spider (Diaea dorsata) Image Stacking, Reflected Light 20X (Objective Lens Magnification) 14th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Recrystallized mixture of hydroquinone and myoinositol Polarized Light 10X (Objective Lens Magnification) 15th Place Sébastien Malo Saint Lys, Haute-Garonne, France Isolated scales on Madagascan sunset moth wing (Chrysiridia ripheus) Darkfield, Image Stacking, Reflected Light 40X (Objective Lens Magnification) 16th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Two water fleas (Daphnia sp.) with embryos (left) and eggs (right) Darkfield, Polarized Light 10X (Objective Lens Magnification) 17th Place Dr. Frantisek Bednar Svosov, Zilinsky, Slovak Republic Stonewort algae (Chara virgata) reproductive organs - oogonia (female organs) and antheridia (male organs) Darkfield 4X (Objective Lens Magnification) 18th Place Alison Pollack San Anselmo, California, USA An insect egg parasitized by a wasp Image Stacking, Reflected Light 10X (Objective Lens Magnification) 19th Place Alison Pollack San Anselmo, California, USA Seed of a Silene plant Image Stacking, Reflected Light 10X (Objective Lens Magnification) 20th Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Early stage of mouse neuroblastoma cell differentiation (actin, microtubules, and mitochondria) Super-Resolution 100X (Objective Lens Magnification) HM Christopher Algar Hounslow, Middlesex, United Kingdom Brine shrimp Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) HM Dr. Kseniia Bondarenko University of Edinburgh Institute for Immunology and Infection Research Edinburgh, MidLothian, United Kingdom Acute-stage parasites of Toxoplasma gondii in a human skin cell Expansion Microscopy, Confocal, Deconvolution 100X (Objective Lens Magnification) HM Dr. Anja de Lange University of Cape Town Neuroscience Institute & Department of Human Biology Cape Town, Western Cape, South Africa Astrocytes surrounding a blood vessel in a thin slice of human brain Confocal 40X (Objective Lens Magnification) HM Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Intestinal villi Fluorescence 20X (Objective Lens Magnification) HM Daniel Evrard Aywaille, Liege, Belgium Vinyl player needle on scratched vinyl disk Image Stacking, Polarized Light 20X (Objective Lens Magnification) HM Randy Fullbright Fullbright Studio Vernal, Utah, USA Agatized dinosaur bone Image Stacking 10X (Objective Lens Magnification) HM Dr. David Maitland St. Andrews, Fife, United Kingdom Transverse section of rachis (stem) of bracken fern (Pteridium aquilinum) Differential Interference Contrast (DIC) 5X (Objective Lens Magnification) HM Angus Rae Australian National University Centre for Advanced Microscopy MacGregor, Australian Capital Territory, Australia Autofluorescence in the face of a little two-spotted ladybird (Diomus notescens) Fluorescence lifetime imaging microscopy (FLIM) 20X (Objective Lens Magnification) HM Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Antenna of a mole crab Confocal 10X (Objective Lens Magnification) HM Jochen Stern Mannheim, Baden-Wuerttemberg, Germany Golden bug eggs on a sage leaf Image Stacking 20X (Objective Lens Magnification) HM Dr. Bruce Douglas Taubert Glendale, Arizona, USA Ocelli between the compound eyes of a yellow jacket Reflected Light 10X (Objective Lens Magnification) HM Kevin Terretaz CRBM-CNRS Montpellier, Hérault, France Mosquito cells in culture with fluorescent markers for DNA and microtubules Confocal 63X (Objective Lens Magnification) IoD Dr. Sherif Abdallah Ahmed Tanta University, Faculty of Science Department of Zoology Tanta, Egypt, Arab Republic Anterior section of palm weevil Image Stacking 4X (Objective Lens Magnification) IoD Anne Patricia Algar Hounslow, Middlesex, United Kingdom Mosquito larva Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) IoD Dr. Florian Alonso University of Bordeaux BioTis-INSERM U1026 Pessac, Gironde, France Mouse aortic endothelium stained for beta-catenin (green), laminin (purple), smooth muscle actin (red), and Hoechst (cyan) Confocal 63X (Objective Lens Magnification) IoD Didier Barbet Club Français de Microscopie Bailly, France Fracture surface of mica (mineral) Differential Interference Contrast (DIC) 10X (Objective Lens Magnification) IoD Timothy Boomer WildMacro.com Vacaville, California, USA Slime mold (Prototrichia metallica) Image Stacking 10X (Objective Lens Magnification) IoD Zhang Chao National Astronomical Observatories, Chinese Academy of Sciences Beijing, China Beach sand Reflected Light 10X (Objective Lens Magnification) IoD Joshua Coogler Dallas, North Carolina, USA Moss sporophyte with spores (green) Image Stacking 10X (Objective Lens Magnification) IoD Nikky Corthout & Miranda Dyson VIB (Flanders Institute of Biotechnology) Center for Brain and Disease Research Leuven, Vlaams-Brabant, Belgium Fruit fly (Drosophila) brain vasculature Confocal, Fluorescence, Image Stacking, Super-Resolution 25X (Objective Lens Magnification) IoD Nadia Efimova Amicus Therapeutics Philadelphia, Pennsylvania, USA Dandelion pappus Confocal, Fluorescence 20X (Objective Lens Magnification) IoD Dr. Laurent Formery & Dr. Nathaniel Clarke Stanford University Department of Molecular and Cell Biology Pacific Grove, California, USA Nervous system of a young sea star Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Karl Gaff Dublin, Ireland Larva of a midge fly (Chironomidae) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Dr. Nick Gatford University of Oxford Nuffield Department of Clinical Neurosciences (NDCN) Oxford, Oxfordshire, United Kingdom A network of dopaminergic neurons generated from human stem cells Super-Resolution 63X (Objective Lens Magnification) IoD Dr. Saikat Ghosh National Institutes of Health NICHD Bethesda, Maryland, USA Human neurons Confocal 40X (Objective Lens Magnification) IoD Gerd A. Günther Düsseldorf, Germany Cross section of a beach grass (Ammophila arenaria) leaf Fluorescence 20X (Objective Lens Magnification) IoD Anna-Mari Elisabeth Haapanen-Saaristo University of Turku Turku Bioscience Centre / Cell Imaging & Cytometry Core and Zebrafish Core RAISIO, Varsinais-Suomi, Finland Nutrient storage cells in a tardigrade Confocal 25X (Objective Lens Magnification) IoD Dr. Martin Hein Lions Eye Institute Physiology and Pharmacology laboratory Nedlands, Western Australia, Australia Abnormal blood vessel formation in a human retina with severe diabetic retinopathy Confocal 20X (Objective Lens Magnification) IoD Wen Jie Ji Yin Works The Bureau of Microworld Exploration Beijing, China Integrated circuit chip Reflected Light 10X (Objective Lens Magnification) IoD Ted Kinsman Rochester Institute of Technology Photosciences Department Rochester, New York, USA A common house cat claw Polarized Light 10X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Opening of a hibiscus flower (Hibiscus moscheutos) exposing the pollen in four stages, each ten minutes apart Image Stacking 20X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Dorsal part of cuckoo wasp (Hedychrum gerstaeckeri) abdomen Image Stacking 20X (Objective Lens Magnification) IoD Dr. Håkan Kvarnström Bromma, Sweden Peacock plume feather Epi-Illumination, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Ewa Langner Washington University in St Louis Department of Medicine - Renal Division, Mahjoub Lab St Louis, Missouri, USA Mouse embryonic kidney showing interstitial fibroblasts (yellow), tubular epithelium (cyan), and nuclei (magenta) Confocal, Fluorescence, Image Stacking 40X (Objective Lens Magnification) IoD Dr. Amir Maqbool Lovely Professional University Department of Zoology Srinagar, Jammu and Kashmir, India Small fly killed by "zombie fly" fungus (Entomophthora muscae) Image Stacking 2X (Objective Lens Magnification) IoD Dr. Robert Markus University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Dandelion (Traxacum officinale) cross section showing curved stigma with pollen Confocal 10X (Objective Lens Magnification) IoD Dr. Robert Markus, Dr. Zeeshan Mohammad, Dr. Sarah Pashley & Dr. Rita Tewari University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Malaria parasites and mouse blood cells - tubulin (green), all proteins (purple), DNA (red) Confocal 63X (Objective Lens Magnification) IoD Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of a black Bagnoli truffle (Tuber mesentericum) Confocal 63X (Objective Lens Magnification) IoD Dr. Guillermo Moya Johns Hopkins University Department of Biology Baltimore, Maryland, USA Neuronal axons connecting to the muscles of the iris and the cornea Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Jacek Myslowski Wloclawek, Kujawko-Pomorskie, Poland Water mite (Arrenurus) Fluorescence, Image Stacking 6.3X (Objective Lens Magnification) IoD Aryah Nagarajan Falmouth University Institute of Photography Penryn, Cornwall, United Kingdom Spores releasing from the sori of a Polypody fern (Polypodium vulgare) Reflected Light, Transmitted Light, Focus Stacking 10X (Objective Lens Magnification) IoD Thomas Neumann Tübingen, Baden-Württemberg, Germany Ink dot on Japanese washi paper Brightfield, Image Stacking 20X (Objective Lens Magnification) IoD Satu Paavonsalo & Dr. Sinem Karaman University of Helsinki Individualized Drug Therapy Research Program, Faculty of Medicine, Helsinki, Finland Helsinki, Finland Blood vessels (color gradient) and endothelial cell nuclei (white) in the intestinal villi of a mouse Confocal 10X (Objective Lens Magnification) IoD Uwe Lange Hannover, Niedersachsen, Germany Pollen on the compound eyes of a fly Image Stacking 60X (Objective Lens Magnification) IoD Dr. Marko Pende MDI Biological Laboratory Murawala Lab Bar Harbor, Maine, USA Ladybug (Coccinellidae) on a clover (Trifolium repens) Confocal, Fluorescence, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Felice Placenti FP Nature and Landscape Photography Siracusa, Sicilia, Italy Potato tuber sprout Image Stacking, Reflected Light 1X (Objective Lens Magnification) IoD Alison Pollack San Anselmo, California, USA Slime mold (Lamproderma arcyrioides) Image Stacking, Reflected Light 10X (Objective Lens Magnification) IoD Dr. Gonzalo Quiroga Artigas CRBM-CNRS Montpellier, Herault, France Tardigrade (Hypsibius exemplaris) Confocal 40X (Objective Lens Magnification) IoD Chris Romaine Kandid Kush Port Townsend, Washington, USA Bract (part of the plants reproductive structures) of a cannabis plant. The bulbous glands are trichomes. Image Stacking 20X (Objective Lens Magnification) IoD Dr. Adolfo Ruiz De Segovia PARTICULAR Madrid, Spain Plant root Fiber Optic 2X (Objective Lens Magnification) IoD Yurim Seo, Dr. Mark Looney & Dr. Simon Cleary University of California, San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine San Francisco, California, USA Lymphatic vasculature (cyan) and vessels (red) of a mouse lung Confocal 4X (Objective Lens Magnification) IoD Dr. Leo Serra University of Cambridge Sainsbury Laboratory Cambridge, Cambridgeshire, United Kingdom Leaves arising from thale cress (Arabidopsis thaliana) meristem Confocal 20X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Aster anther cross section with pollen grains (green) Confocal 40X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Floret of a common chicory with pollen grains (spiky balls) Confocal 40x (Objective Lens Magnification) IoD Luna Šošo Zdravković, Michael Surala & Christian Madry Charité Universitätsmedizin Berlin Institute of Neurophysiology Berlin, Germany Pyramidal neuron in mouse hippocampus Confocal, Fluorescence, Image Stacking 30X (Objective Lens Magnification) IoD Dr. Bruce Douglas Taubert Glendale, Arizona, USA Mid-tibial tuft on a male orchid bee, used to attract mates Reflected Light 10X (Objective Lens Magnification) IoD Maxime Teixeira Laval University Department of Molecular Medicine Québec, Canada Cultured monkey kidney cells labeled for tubulin (blue) and actin (orange) showing pathological accumulation of alpha-syn aggregates (red) Confocal, Deconvolution, Image Stacking, Super-Resolution 100X (Objective Lens Magnification) IoD Dr. Theo Theune Oost-Souburg, Zeeland, Netherlands Abdominal skin of a tick that engorged with blood Image Stacking 50X (Objective Lens Magnification) IoD Dr. Grigorii Timin & Dr. Michel Milinkovitch University of Geneva Department of Genetics and Evolution Geneva, Switzerland Skin scales of a snake embryo stained with Fast Green dye Confocal 63X (Objective Lens Magnification) IoD Steven A. Valley Oregon Department of Agriculture (ODA) Entomology Lab Albany, Oregon, USA Immature male damselfly (Calopteryx aequabilis) Image Stacking, Reflected Light 5X (Objective Lens Magnification) IoD Dr. Bruno Vellutini Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Saxony, Germany Gene expression patterns in a drain fly embryo (Clogmia albipunctata) with an open eggshell Confocal 20X (Objective Lens Magnification) IoD Susannah Waxman & Dr. Ian Sigal University of Pittsburgh Department of Ophthalmology Pittsburgh, Pennsylvania, USA Optic nerve head collagen of a pig Image Stacking, Multiphoton 25X (Objective Lens Magnification) IoD Shao Yang Beijing Miteyide Culture Co., Ltd. Beijing, China Fiber of nylon stockings Polarized Light 5X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Graffiti from Berlin Wall stone section Image Stacking, Top Illumination 10X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Water mite (Hydrachna sp.) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Elkhan Yusifov & Dr. Martina Schaettin University of Zurich Department of Molecular Life Sciences Zurich, Switzerland Developing nervous system in the eye of a 7-day-old chick embryo Stereomicroscopy 10X (Objective Lens Magnification) IoD Ou Zhilei Guangdong Radio and Television Guangzhou, Guagndong, China Stamens of flowers (Anemone cathayensis Kitag. ex Ziman & Kadota) Image Stacking 10X (Objective Lens Magnification) About Nikon Small World Photomicrography Competition The Nikon Small World Competition is open to anyone with an interest in photography or video. Participants may upload digital images and videos directly at . For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or phone (631) 547-8569. Entry forms for Nikon's 2025 Small World and Small World in Motion Competitions are available at . About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacturing of optical, digital imaging technology and software for biomedical applications. For more information, please visit or contact us at 1-800-52-NIKON. SOURCE Nikon Instruments Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

30 Jul 2024

·www.echemi.com

To Explore the Application of

In recent years,"myo inositol powder" has generated much discussion in the field of women's health. As a natural physiologically active compound, inositol can effectively maintain endocrine balance, while helping to resist the invasion of a variety of chronic diseases. This article will provide an in-depth analysis of the key role of myo inositol powder in the maintenance of women's health, and put forward corresponding guidance for use, so as to provide a solid guarantee for women's health. For women, health is undoubtedly a priceless asset. However, modern fast-paced lifestyles often expose us to a variety of health challenges, such as common diseases such as polycystic ovary syndrome (PCOS). As an endocrine disorder, PCOS not only affects women's reproductive function, but also may lead to a series of serious complications. In dealing with PCOS, the role of myo inositol powder cannot be ignored. Inositol, as a naturally occurring physiologically active substance in human body, can effectively regulate insulin metabolism, thereby improving insulin resistance and alleviating the symptoms of PCOS. A large number of studies have shown that appropriate supplementation of myo inositol powder can significantly improve the fertility of patients with PCOS while preventing the occurrence of related complications. The benefits of myo inositol powder are not limited to the treatment of PCOS, it also plays a positive role in menstrual management in women, menopausal symptoms relief, and prevention of type 2 diabetes and cardiovascular disease. Therefore, women can consider appropriate intake of myo inositol powder to add a line of defense to their health. However, relying solely on the supplement of myo inositol powder is not enough. We also need to make comprehensive adjustments in diet structure, living habits and other aspects. For example, increase the intake of dietary fiber, vitamins and minerals, reasonable control of sugar and fat intake; At the same time, maintain adequate sleep, regular rest and rest, and appropriate exercise. Only through comprehensive management, can we truly achieve the comprehensive promotion of women's health. Myo inositol powder provides a powerful support for women's health, but we should avoid viewing it as the only solution. A comprehensive health management strategy should be adopted according to the individual's specific situation. Only in this way can the majority of women truly embrace a healthy and beautiful future.

30 Jul 2024

·www.echemi.com

Women's Health From the Perspective of

"Myo inositol PCOS", a topic that has attracted much attention in the medical field in recent years, reveals the subtle relationship between endocrine disorders and women's health. Polycystic ovary syndrome (PCOS) is a common gynecological disorder that affects a wide range of women, from reduced fertility to a range of health problems. The discovery of "myo inositol PCOS" offers new hope for improving the condition of PCOS patients. The pathogenesis of PCOS is complex, in which the imbalance of myo inositol PCOS plays a key role. Reduced levels of inositol, a substance that occurs naturally in the body, can lead to insulin resistance, which in turn triggers or exacerbates the symptoms of PCOS. A large number of studies have confirmed that through the supplement of "myo inositol", the normal insulin response in the body can be restored, thereby improving the symptoms of irregular menstruation, acne, hirsutism and other symptoms, and improving the quality of life of patients. However, the supplementation of "myo inositol PCOS" is only the first step in treating PCOS. In order to achieve the overall improvement of women's health, we also need to pay attention to the adjustment of diet structure and lifestyle changes. It is recommended that patients increase whole grains, vegetables, fruits and other fiber-rich foods to enhance the body's ability to process sugar, while reducing the intake of sugar and saturated fat to prevent the type 2 diabetes and cardiovascular disease complicated by PCOS. In addition, maintaining adequate sleep, a regular schedule, and proper exercise can all help improve the endocrine environment and further relieve the symptoms of PCOS. It is important to note that the physique and symptoms of each PCOS patient are different, so when implementing the treatment plan, a personalized health management plan should be developed according to the specific circumstances of the individual. This may include regular medical checkups, professional nutritional counseling, and even psychological counseling to ensure that the patient is fully supported, both physically and psychologically. The discovery of "myo inositol PCOS" opens new avenues for the treatment of PCOS, but we should also recognize that comprehensive health management is the key to defeating PCOS. Only through a comprehensive and individualized treatment strategy can we help women out of the shadow of PCOS, regain their health and confidence, and embrace a better future.

100 Deals associated with Inositol

External Link

KEGG	Wiki	ATC	Drug Bank
D08079	Inositol	A11HA07	DB13178

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Arteriosclerosis	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Fatty Liver	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Hepatitis	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Hyperlipidemias	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Liver Cirrhosis	CN	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NiPPeR Randomized Trial (Pubmed \| Fertil Steril)	Not Applicable	-	1,729	myo-inositol, probiotics and micronutrient supplement (Standard supplement (control))	dwizhclnkt(rbmndyusgy) = uxcsqklvcb yxwfuhzovl (xlzaxrlbpz, 76.0 - 105.1)	-	06 Feb 2023
				Intervention supplement (myo-inositol, probiotics, and micronutrients)	dwizhclnkt(rbmndyusgy) = tukcunasfw yxwfuhzovl (xlzaxrlbpz, 80.7 - 103.5)
NCT02397291 (CTgov)	Not Applicable	Pregnancy \| Fetal Growth Retardation	24	Placebo (Part 1: Measurements of Maternal and Fetal Concentrations)	zpqfguciqf(kkacszvjmi) = sanisjzxmu qkoorqvces (hmzxpbeucr, vwyxnwpirb - fmyiyniwaa) View more	-	11 Nov 2021
				Myoinositol+Mannose (Part 2: Stable Isotope Studies)	zpqfguciqf(kkacszvjmi) = cpszrixfvw qkoorqvces (hmzxpbeucr, edgzxcsndo - vfhagmxxtr) View more
NCT01030575 (INS-2, CTgov)	Phase 2	Bronchopulmonary Dysplasia \| Obstetric Labor, Premature \| Retinopathy of Prematurity	125	Inositol lower volume (Inositol Low Volume)	emkzogahvg(qovocmlths) = pzfuhzrzyc wmawvjjbxy (mxitmqosvr, dpsmareidx - lwljtskpup) View more	-	12 Mar 2021
				Inositol mid-level volume (Inositol Mid-level Volume)	emkzogahvg(qovocmlths) = zjvwyxvhau wmawvjjbxy (mxitmqosvr, killxjadhq - gsfpuvjumd) View more
NCT01396486 (CTgov)	Phase 4	Mania \| Bipolar Disorder	69	Omega-3 (Omega-3/Placebo)	blwbygtvhj(ikhsyhkhol) = oqavxjmpzf mwiyjfztih (nwpebkyogm, uzsmovdhju - rcplvazdtt) View more	-	21 Apr 2020
				Inositol (Placebo/Inositol)	blwbygtvhj(ikhsyhkhol) = ckohzhamaf mwiyjfztih (nwpebkyogm, emhqcacpfx - djqjhcgjsv) View more
NCT01954082 (INS-3, CTgov)	Phase 3	Retinopathy of Prematurity	638	myo-Inositol 5% Injection (Myo-Inositol 5% Injection)	ijzrjblyyx(qncsquuvms) = cfkzyybzdi bbcwtfkrro (fubftjdjcy, wahgtqrphp - bdhssgbeol) View more	-	26 Sep 2018
				Placebo (5% Glucose(Dextrose))	ijzrjblyyx(qncsquuvms) = ttfncxavfc bbcwtfkrro (fubftjdjcy, ihclxvqaiw - szcoyqudib) View more
Pubmed \| Diabetes Care	Not Applicable	Diabetes, Gestational	-	Intervention group (1,100 mg myo-inositol, 27.6 mg D-chiro-inositol, and 400 μg folic acid)	guwzbflztm(rgriqbaaju) = gzdphftibv suaqmfpuon (vovouljycu ) View more	-	01 Jun 2017
				Control group (400 μg folic acid only)	guwzbflztm(rgriqbaaju) = btedbgbgpi suaqmfpuon (vovouljycu ) View more
NCT01875445 (CTgov)	Phase 2	Trichotillomania	38	Placebo (Placebo)	zvovcjrclo(dlchcqfcgx) = fzuctbifnf nzpuqjzicd (wsnramoamv, jnktugqieq - aqeuenwknj) View more	-	19 May 2017
				Inositol (Inositol)	zvovcjrclo(dlchcqfcgx) = mgfmfrxtad nzpuqjzicd (wsnramoamv, pdoismjtjk - aifeohavnu) View more
NCT01111292 (CTgov)	Phase 1/2	Recurrent Colon Cancer \| Rectal Cancer \| Crohn Disease ... View more	5	Inositol (Arm I (Inositol))	xjzhsknxnh(xtqlidedjl) = faipkcxdrd imxfqrpqns (yxcycmiosq, jqmacfzkrc - flzzpvcpls) View more	-	12 Jul 2016
				Placebo (Arm II (Placebo))	xjzhsknxnh(xtqlidedjl) = yomymhjhht imxfqrpqns (yxcycmiosq, kmvythopzh - aopwpndzte) View more
NCT00783705 (CTgov)	Phase 2	Non-Small Cell Lung Cancer \| Bronchial Diseases	85	inositol (Arm A (Myo-inositol))	tutbnlzcwa(kdtrmgpywp) = twhqtsmiro uahuydwnlv (bxtnveewvg, hryotoqtbb - gxidriijrl) View more	-	25 Aug 2015
				Placebo (Arm B (Placebo))	tutbnlzcwa(kdtrmgpywp) = xytimvjijb uahuydwnlv (bxtnveewvg, kiuhgprsvw - ifphxkmuwk) View more
NCT00012558 (STEP-BD, Pubmed \| Am J Psychiatry)	Not Applicable	Depressive Disorder, Treatment-Resistant	66	Lamotrigine	vacdifqzlr(qvnelsftfp) = airmusltdn fcmhkvakpb (efalojfhll )	Positive	01 Feb 2006
				Inositol	vacdifqzlr(qvnelsftfp) = bwiekloogv fcmhkvakpb (efalojfhll )

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