A phase III, multi-center, double-blind, randomized, vehicle controlled trial in a parallel-group design to evaluate the efficacy and safety of two formulations of Muxan containing 0.5 % or 1 % chloramine-T compared to vehicle in patients aged 12 years or older with acute herpes labialis

Start Date12 Jan 2011

Sponsor / Collaborator

Engelhard Arzneimittel GmbH & Co. KG

100 Clinical Results associated with Chloramine T

100 Translational Medicine associated with Chloramine T

100 Patents (Medical) associated with Chloramine T

840

Literatures (Medical) associated with Chloramine T

01 Jan 2025·Water Research

Occurrence, toxicity, and control of halogenated aliphatic and phenolic disinfection byproducts in the chlorinated and chloraminated desalinated water

Article

Author: Ma, Yingjie ; Tao, Hongfei ; Jiang, Youwei ; Wang, Xianshi ; Tan, Yirang ; Qiao, Yue ; Ma, Jun ; Zang, Shuang ; Li, Qiao

Seawater desalination is widely used to overcome the freshwater shortage worldwide. However, even after three-stage reverse osmosis treatment, the desalinated water still contained 14.6 μg/L of aliphatic disinfection byproducts (DBPs), 384.2 ng/L of bromophenolic DBPs, 3.5 ng/L of iodophenolic DBPs, 1024.7 μg/L of Br^-, 2.8 μg/L of I^-, and 2.4 mg C/L of dissolved organic carbon (DOC). After the desalinated water was disinfected with chlor(am)ine, the concentrations of halogenated aliphatic and phenolic DBPs further increased, and bromophenolic DBPs were the toxicity forcing agents. When surface water was mixed with desalinated water and then chlorinated, the yield of aliphatic and phenolic DBPs significantly elevated. Separately chlorinating desalinated water and surface water before mixing could mitigate this adverse situation. Chloramine disinfection was more conducive to reducing the total calculated toxicity of disinfected desalinated waters and mixed waters compared to chlorine disinfection. The treatment of desalinated water with granular activated carbon could effectively remove DOC and UV₂₅₄, leading to a reduction in the content of total organic halogen after chlor(am)ination. Although anion exchange resin could adsorb Br^-, it also released the organic precursors of DBPs, ultimately increasing the yield of DBPs. The results of this study can provide a reference for the seawater desalination industry to improve seawater pre-treatment and desalination processes and thus minimize the DBPs.

01 Dec 2024·Journal of Hazardous Materials

Controlling iron release and pathogenic bacterial growth in distribution pipes through nanofiltration followed by different disinfection methods

Article

Author: Mi, Xiao ; Ju, Xiurong ; Shi, Baoyou ; Wang, Haibo ; Yang, Xinyuan

There is increasing concern about discoloration problems and microbial risks in drinking water. Until recently, how to control iron release and pathogenic bacterial growth in distribution pipes has been a knowledge gap. In our study, nanofiltration removed 13.3 % of lignins, 33.1 % of tannins and 17.7 % of proteins from dissolved organic matter (DOM). These DOM components were closely related to enzymes involved in the tricarboxylic acid (TCA) cycle. Therefore, nanofiltration followed by chlorine or chloramine disinfection inhibited the TCA cycle and induced lower adenosine triphosphate (ATP) and extracellular polymeric substance (EPS) production, resulting in reduced pathogenic bacterial growth. The number of Pseudomonas aeruginosa decreased to 7.43 × 10⁵ and 2.43 × 10⁵ gene copies/mL, respectively. Moreover, lower DOM concentrations increased the abundance of iron-reducing bacteria (IRBs) in the biofilm. IRBs can convert Fe(III) into Fe(II) through cellular c-type cytochromes, including CymA, MtrA, Cytc3, MacA, PpcA, and OcmB. The higher abundance of IRB and their cytochromes led to more Fe₃O₄ formation on the surface of the distribution pipes, resulting in lower iron release. The total iron concentration was 16.9 μg/L in the effluent of pipes treated with nanofiltration and chloramine disinfection. Therefore, nanofiltration followed by different disinfection methods, especially chloramine disinfection, effectively controlled iron release and pathogenic bacterial growth in distribution pipes. This study strongly contributes to maintaining the drinking water quality in distribution pipes.

01 Nov 2024·Health Science Reports

Modelling the cost‐effectiveness of a chloramine gel in treating infected, non‐healing diabetic foot ulcers

Article

Author: Guest, Julian F. ; Eliasson, Björn

AbstractBackground and aimsOrganic chloramines have been developed as a topical wound bed preparation gel. This study aimed to estimate whether the addition of chloramine gel (Chlorasolv, RLS Global AB, Sweden) to standard care compared with standard care alone would afford a cost‑effective technology to the UK's health services for treating infected, non‐healing diabetic foot ulcers (DFUs).MethodsA Markov model was developed to simulate the management of infected, non‐healing DFUs. The model utilised data from a randomised controlled trial and was used to estimate the cost‐effectiveness of chloramine plus standard care compared with standard care alone over a period of 24 weeks, expressed as the incremental cost per quality‐adjusted life year (QALY) gained at 2021/22 prices.ResultsUsing adjunctive chloramine to treat infected, non‐healing DFUs was found to shorten the time to healing by 36% (from a mean of 17.1 weeks per ulcer to a mean of 11.0 weeks per ulcer). This translated into a 6% improvement in the probability of being healed by 24 weeks and a corresponding 3% improvement in health‐related quality of life (HRQoL). Also, use of adjunctive chloramine was found to reduce the total cost of ulcer management by 13%. Sensitivity analysis found that adjunctive chloramine remained a cost‐effective treatment, even when the value of the model inputs was varied by ±20%.ConclusionWithin the limitations of the study, treatment with adjunctive chloramine instead of standard care alone could potentially afford the UK's health services a cost‐effective debridement strategy for infected, non‐healing DFUs, due to its ability to accelerate the time to healing.

100 Deals associated with Chloramine T

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KEGG	Wiki	ATC	Drug Bank
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Indication	Country/Location	Organization	Date
Herpes Labialis	DE	Engelhard Arzneimittel GmbH & Co. KG	20 Dec 2007

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2020	Not Applicable	-	-	Chloramine-T (MAb-B10 conjugate)	dmcdgfnldb(eaivopcrud) = zvbqjmputc irndkybchh (suezcdfmoo )	-	15 May 2020

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