Delving into the Latest Updates on Selenious Acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Selenious acid (USP), Selenous acid

Target-

Action-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Nutrition Disorders

Inactive Indication-

Originator Organization

American Regent, Inc.

Active Organization

American Regent, Inc.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (30 Apr 2019),

Nutrition Disorders

RegulationFast Track (United States)

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Structure/Sequence

Molecular FormulaH2O3Se

InChIKeyMCAHWIHFGHIESP-UHFFFAOYSA-N

CAS Registry7783-00-8

Improving leaching rate is crucial in the hydrometallurgical recovery of valuable metals from copper anode slime.The complexity of the composition makes it challenging to clarify the leaching behavior of multiple components, and there is limited research available on this topic.Here, H₂O₂ was selected to enhance the leaching performance, and the leaching behaviors of Cu, Se, Te, and Ag were systemically investigated by using a real copper anode slime sample.Indicate that H₂O₂ significantly improves the leaching efficiency of multiple components.Under the optimum conditions, the leaching efficiencies of Cu, Se, Ag, and Te were 96.18%, 90.58%, 80.21%, and 66.72%, resp.As the concentration of H₂O₂ increases, the multiple components were leached in a specific order: Cu₂Te > Cu₂Se > Ag₂Te > Ag₂Se.Based on the XPS and XRD results, along with thermodn. and kinetic calculations, a two-step oxidative leaching reaction mechanism for copper anode slime was proposed.The oxidative leaching process can be divided into two stages.In the first stage, metallic compounds undergo oxidative separation, wherein, copper and silver are converted into soluble Cu²⁺ and Ag⁺ while selenium and tellurium are transformed into insoluble Se⁰ and TeO₂.In the second stage, the Se⁰ and TeO₂ are further converted into soluble H₂SeO₃/H₂SeO₄ and H₆TeO₆.The results of this work offer theor. guidance for designing oxidative leaching technol. for copper anode slime.

01 Jul 2025·Biomaterials

Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation

Article

Author: Qing, Guangchao ; Ji, Jianing ; Yang, Zhan ; Wang, Zhizeng ; Duan, Shujie ; Ma, Ziwei ; Guo, Keying ; Xue, Menghan ; Chen, Tianfeng ; Luo, Yang ; Wu, Wei ; Ma, Yuanfang ; Chen, Chunxia ; Ma, Jingjing

Ischemia/reperfusion injury (I/RI) following myocardial infarction, a leading cause of global morbidity and mortality, is characterized by detrimental oxidative stress and inflammation. In response, we proposed an I/RI alleviation strategy using the intravenous injection of spherical selenium nanoparticles (SeNPs) synthesized by a template method. Single-cell sequencing revealed these proposed SeNPs exhibited exceptional antioxidant and anti-inflammatory properties, disrupting the STAT1-ROS cycle, therefore preserving mitochondrial respiration and inhibiting caspase-mediated cardiomyocyte apoptosis. Additionally, SeNPs reduced macrophage infiltration and diminished the subsequent release of inflammatory mediators during I/RI. In vivo, SeNPs significantly improved myocardial function while decreasing myocardial apoptosis and fibrosis. These results collectively demonstrated that template method synthesized spherical SeNPs may serve as a promising candidate for enhancing myocardial infarction treatments, while the suppression of STAT1 could be a pivotal mechanism for alleviating ischemia/reperfusion injury following myocardial infarction.

01 Jun 2025·Hydrometallurgy

A thermodynamic and kinetic study of efficient selenium removal from highly acidic TeCl4 solution using tellurium powder

Author: Qian, Weilun ; Zheng, Guoqu ; Cao, Huazhen ; Kong, Junfeng ; Tang, Anyang ; Wang, Wenqiu ; Liu, Zhengzheng ; Zhang, Huibin ; Yu, Lining

High-purity tellurium is in high demand for applications in high-tech fields such as semiconductors and solar cells.To produce high-purity tellurium, one of the challenges is to effectively reduce selenium content of telluride (IV) solutionThis study reports the thermodn. and kinetic anal. for selenium removal by tellurium powder substitution in a TeCl₄ solutionThe thermodn. anal. revealed that the separation window of tellurium and selenium significantly varies with pH.Solutions of weak acidity or basicity are unfavorable for the separation of these two elements.In highly acidic systems, tellurium coexists with selenite ions in the form of Te⁴⁺ ions, and the redox equilibrium potential values for E(Te⁴⁺/Te) and E(H₂SeO₃/Se) significantly differ, indicating the thermodn. feasibility of selenium removal through tellurium powder replacement.Under optimal reaction condition, the selenium removal efficiency in highly acidic tellurium tetrachloride could reach ∼99.9% with a residual selenium concentration of 0.1 mg/L.Kinetic studies indicated that selenium removal by tellurium powder substitution is primarily controlled by a chem. reaction with an apparent activation energy of 84.6 kJ/mol.This study provides a simple but efficient method for of selenium impurity removal toward high-purity tellurium.

100 Deals associated with Selenious Acid

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