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Last update 31 Jan 2026
Ipratropium Bromide
Last update 31 Jan 2026
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Ipratropium bromide (USP), Ipratropium Bromide Hydrate, Ipratropium bromide hydrate (JP17) + [8] |
Target |
Action antagonists |
Mechanism mAChRs antagonists(Muscarinic acetylcholine receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date Japan (25 Oct 1980), |
Regulation- |
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Structure/Sequence
Molecular FormulaC20H32BrNO4 |
InChIKeyKEWHKYJURDBRMN-ZEODDXGYSA-M |
CAS Registry66985-17-9 |
Related
118
Clinical Trials associated with Ipratropium BromideITMCTR2026000018
Analysis of Efficacy and Safety of Bailing Capsules Combined with Ipratropium Bromide for COPD with Cor Pulmonale
CTR20252731
单中心、随机、开放、两序列、两周期交叉设计评估中国健康研究参与者非炭阻、空腹状态下经口吸入异丙托溴铵吸入气雾剂的生物等效性试验
[Translation] A single-center, randomized, open-label, two-sequence, two-period crossover design to evaluate the bioequivalence of oral ipratropium bromide inhalation aerosol in participants of the China Health Study in the non-carbuncle-free, fasting state
CTR20250540
异丙托溴铵吸入气雾剂人体生物等效性研究
[Translation] Study on the bioequivalence of ipratropium bromide inhalation aerosol in healthy volunteers
100 Clinical Results associated with Ipratropium Bromide
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100 Translational Medicine associated with Ipratropium Bromide
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100 Patents (Medical) associated with Ipratropium Bromide
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2,067
Literatures (Medical) associated with Ipratropium Bromide01 Apr 2026Intensive and Critical Care Nursing
Practice of nebulization in intensive care unit patients receiving invasive ventilation – A nationwide survey
Article
Author: Dongelmans, Dave A ; Stilma, Willemke ; Esmeijer, Andrea A ; Visser, Annelies ; Paulus, Frederique ; Mugge, Sarah F C
BACKGROUND:
Nebulization with mucolytic and bronchodilator agents is frequently applied in Intensive Care Units (ICUs) for invasively ventilated patients, despite limited evidence for clinical benefit and potential risks associated with routine use. Understanding current practice and rationale behind nebulization is essential to targeted de-implementation strategies.
METHODS:
We conducted a nationwide, cross-sectional telephone survey among ICU healthcare professionals in the Netherlands. The survey addressed nebulization practices for mucolytics and bronchodilators, including agents used, administration strategy, clinical indications, evaluation strategies, and local protocols. Open-ended questions explored underlying clinical reasoning and factors influencing nebulization practices.
RESULTS:
Representatives from 54 of 71 Dutch ICUs (76%) participated. Most respondents were ventilation practitioners (72%, 39/54), supplemented by ICU nurses and intensivists. Nebulization with mucolytics was reported in 47 ICUs (87%) ICUs and with bronchodilators in all ICUs. On-demand nebulization predominated (91.5%, 43/47 for mucolytics; 83.3%, 45/54 for bronchodilators). Thick secretions were the main indication for mucolytics, whereas obstructive pulmonary disease and bronchospasm were leading indications for bronchodilators. Acetylcysteine and salbutamol/ipratropium were most frequently used. Local protocols were present in 41 (76%) ICUs. Active humidification was commonly applied on indication, particularly in prolonged ventilation. Responses to open-ended questions revealed that, beyond clinical triggers, nebulization decisions were frequently shaped by personal preference, habitual practice, and organizational context, rather than by evidence-based reasoning.
CONCLUSION:
Nebulization in Dutch ICUs is predominantly on-demand but practice remains variable and partly driven by ingrained habits instead of evidence. Non-indicated nebulization persists and represents potential low-value care.
IMPLICATIONS FOR CLINICAL PRACTICE:
This nationwide survey demonstrates that nebulization practices in Dutch ICUs remain highly variable, often driven by non-standardized protocols and subjective interpretation of indications rather than evidence. To promote more consistent and evidence-based care, implementing a practical decision-support tool could guide clinicians toward indication-based nebulization and support de-implementation of routine, non-indicated use.
01 Feb 2026IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Medical Management of Rhinitis
Review
Author: Peters, Anju ; Shaker, Marcus ; Li, Sylvia
Pharmacologic treatment of rhinitis includes intranasal and oral therapies targeting inflammation and histamine activity. Intranasal corticosteroids and non-sedating antihistamines are first-line due to high efficacy and safety. Intranasal ipratropium, cromolyn, and decongestants offer symptom-specific relief. Oral medications such as antihistamines, leukotriene receptor antagonists, decongestants, and corticosteroids, vary in efficacy and side effects. Emerging therapies like biologics and CRTH2/DPP-4 inhibitors show promise in clinical and preclinical studies.
01 Jan 2026The journal of allergy and clinical immunology. Global
Depression in children with asthma: Testing a cholinergically mediated “endotype”
Article
Author: Wood, Beatrice L ; Miller, Bruce D ; Humayun, Quratulain ; Lam, Weyman ; Lehman, Heather K
Background:
Asthma is not a single uniform disease; instead, it comprises various disease sub entities, or "endotypes," with different etiologies and pathophysiologies. As asthma endotypes are discerned, individuals with asthma can be matched with optimal therapies for their specific asthma subtype. Depression is common in persons with asthma and associated with increased asthma-related morbidity and mortality. Depression in child asthma is associated with a predominance of parasympathetic/cholinergic activation over sympathetic activation. Cholinergic activity mediates airway smooth muscle constriction and has effects on airway inflammatory cells and mucus-secreting goblet cells.
Objective:
The goal of the current study was to examine whether children with asthma who have more depressive symptoms have cholinergically mediated disease that is differentially responsive to short-acting anticholinergic therapy.
Methods:
A total of 39 children with asthma (aged 7-17 years) and baseline obstruction on spirometry were evaluated for depressive symptoms by using the Children's Depression Inventory. Spirometry was used to evaluate the children for improvement in airway function following treatment with a short-acting anticholinergic medication. Inflammation was assessed by determining fractional exhaled nitric oxide levels and peripheral blood eosinophil counts, and atopic status was assessed by skin prick testing and measurement of total serum IgE level.
Results:
There was a statistically significant positive correlation between depressive symptoms and increase in FEV1 percent predicted value in response to ipratropium administration (rs = 0.344; P = .032).
Conclusion:
Higher depressive symptom scores are associated with increased airway responsiveness to inhaled ipratropium in children with asthma and active airway obstruction. These findings suggest the potential for definition of an endotype of asthma with comorbid depression that may benefit from anticholinergic asthma therapies.
20
News (Medical) associated with Ipratropium Bromide
05 Jul 2025
Drug Approval
100 Deals associated with Ipratropium Bromide
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D02212 | Ipratropium Bromide |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Rhinitis, Allergic, Seasonal | United States | 27 Oct 2000 | |
| Common Cold | United States | 20 Oct 1995 | |
| Rhinitis | United States | 20 Oct 1995 | |
| Bronchial Spasm | United States | 29 Sep 1993 | |
| Pulmonary Disease, Chronic Obstructive | United States | 29 Sep 1993 | |
| Asthma | Japan | 25 Oct 1980 | |
| Bronchitis, Chronic | Japan | 25 Oct 1980 | |
| Pulmonary Emphysema | Japan | 25 Oct 1980 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Dyspnea | Clinical | Canada | 01 Oct 2008 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | 141 | (Levalbuterol) | utateqfrcq = gzilofymcx hlleyktpho (uyylctelkl, pbirjgxkko - iomncjsreo) View more | - | 16 May 2022 | ||
(Levalbuterol Plus Ipratropium) | utateqfrcq = mquegzghko hlleyktpho (uyylctelkl, ovtroomxld - wyicepfvna) View more | ||||||
Phase 4 | 40 | dobyccrugr(tnzpifhhax) = xtkrihlvwl mkrgxnupnm (feiurcusjq, 25.2) View more | - | 10 Jun 2021 | |||
(Dry Powder Inhaler) | dobyccrugr(tnzpifhhax) = mbfjpnxjod mkrgxnupnm (feiurcusjq, 19.8) View more | ||||||
Phase 4 | 20 | Placebo (Placebo) | jwojvupfrd(lojoadxhtq) = lkoyjoqloy tzrqydlbwy (ujtfuuapkx, fyibnrqaqm - ubjyzcveup) View more | - | 05 Jun 2020 | ||
(Ipratropium Bromide) | jwojvupfrd(lojoadxhtq) = vbpemdxdxo tzrqydlbwy (ujtfuuapkx, bnwxmizjaf - xtadlqnhjc) View more | ||||||
Phase 4 | 20 | (Ipratropium) | oqbphhgvqt(lwbvitfklz) = qrycgfnbix kkterpwvei (pdspfomskp, iabjptskta - lrzsqdfmnf) View more | - | 12 Oct 2016 | ||
(Theophylline) | oqbphhgvqt(lwbvitfklz) = hyehoifbnz kkterpwvei (pdspfomskp, shpnxmsedi - mimddloxkg) View more | ||||||
Phase 4 | 192 | placebo | lohimsqnnj(tildeazlfu) = oogwmweggh scgouwerku (dflyunmjxd, 29.35) View more | - | 12 Sep 2016 | ||
Phase 3 | 15 | (Albuterol-sulphate) | bmjnyoonoq(ufiamaotbm) = pqchhcpjoz focrwmiczw (znzxplwfkq, 13.6) View more | - | 02 Jun 2016 | ||
(Ipratropium-bromide (Atrovent ®)) | bmjnyoonoq(ufiamaotbm) = mwiqcegbon focrwmiczw (znzxplwfkq, 10.9) View more | ||||||
Not Applicable | - | Salbutamol, Prednisolone, and Ipratropium Bromide | puyjuweuhw(sqvfvtwiek) = mmtvkviedc iwvugsgxfo (pjsztsspbg ) View more | - | 01 Feb 2015 | ||
Salbutamol and Prednisolone | puyjuweuhw(sqvfvtwiek) = dzsbnqipoi iwvugsgxfo (pjsztsspbg ) View more | ||||||
Phase 4 | 581 | (Symbicort Turbuhaler + Ipratropium + Theophylline SR) | mqpwqwxuos(rgtecnerlz) = trliuxqnft udhjivxmkq (zdsdeerxhs, ugcqtpentm - trbeopxfpu) View more | - | 26 Aug 2014 | ||
(Ipratropium + Theophylline SR) | mqpwqwxuos(rgtecnerlz) = koigdehxxe udhjivxmkq (zdsdeerxhs, uoxejjnlmw - mfianoswbg) View more | ||||||
Phase 4 | 56 | (Albuterol/Salbutamol Followed by Ipratropium) | fdhcyrzaio(ldauzmkzwg) = unbjeddnia huhxnofzyu (egqcapubpk, 0.0394) View more | - | 25 Dec 2013 | ||
(Ipratropium Followed by Albuterol/Salbutamol) | fdhcyrzaio(ldauzmkzwg) = vlilhbkbpd huhxnofzyu (egqcapubpk, 0.0372) View more |
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