Last update 27 Apr 2025

Anlotinib Dihydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ALTN, Anlotinib, Anlotinib Hydrochloride
+ [6]
Action
antagonists, inhibitors
Mechanism
FGFRs antagonists(Fibroblast growth factor receptors antagonists), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), Tyrosine kinase inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
China (08 May 2018),
RegulationOrphan Drug (United States), Priority Review (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC23H23ClFN3O3
InChIKeyGTAUHBAHFJIAQT-UHFFFAOYSA-N
CAS Registry1360460-82-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Endometrial Carcinoma
China
22 Nov 2024
Extensive stage Small Cell Lung Cancer
China
08 May 2024
Differentiated Thyroid Gland Carcinoma
China
08 Apr 2022
Thyroid Cancer, Medullary
China
30 Jan 2021
Small Cell Lung Cancer
China
01 Sep 2019
Soft Tissue Sarcoma
China
01 Jul 2019
Non-Small Cell Lung Cancer
China
08 May 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Lung Non-Small Cell Squamous CarcinomaNDA/BLA
China
23 Apr 2025
Non-small cell lung cancer stage IIINDA/BLA
China
23 Apr 2025
Hepatocellular CarcinomaNDA/BLA
China
21 Nov 2024
Metastatic Renal Cell CarcinomaNDA/BLA
China
01 Aug 2024
Unresectable Renal Cell CarcinomaNDA/BLA
China
01 Aug 2024
Primary peritoneal carcinomaPhase 3
United States
06 Apr 2022
Primary peritoneal carcinomaPhase 3
United States
06 Apr 2022
Primary peritoneal carcinomaPhase 3
China
06 Apr 2022
Primary peritoneal carcinomaPhase 3
China
06 Apr 2022
Primary peritoneal carcinomaPhase 3
Italy
06 Apr 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Solid tumor
TNM staging
911
kbmohxuaya(cknjueczdm) = 9.7% tkhvchunwe (yqaayloeyy )
Positive
29 Apr 2025
Anlotinib combination therapy
Phase 2
22
安罗替尼+顺铂+白蛋白紫杉醇
aluiqptexk(dbhxxizpvp) = aacndncedz invkjuuglo (ukmvqyaiie )
Positive
14 Apr 2025
Not Applicable
539
qaubatgwzr(bkzarmxdzg) = 10.2% hgkvpkrvwa (jvpjcuxisp )
Positive
26 Mar 2025
Combined therapy
Not Applicable
746
gkqobvoqoo(firgkogryr) = oxodksxkhp cveeypsogg (bmxisrptgv )
Positive
26 Mar 2025
gkqobvoqoo(firgkogryr) = byrgegmzqd cveeypsogg (bmxisrptgv )
Not Applicable
295
grjvkbxkan(emapdhqjlx) = ictiirgzia hyhnkhxlgb (pkxjluabzc, 3.70 - 4.47)
Positive
20 Mar 2025
Anlotinib plus chemotherapy
grjvkbxkan(emapdhqjlx) = tsqlkbbmrs hyhnkhxlgb (pkxjluabzc, 4.10 - 5.53)
Phase 3
73
vteibjwnnk(qejqyixikt) = uexzwulrfp tifvghssbz (sfypjkdlmp, 3.4 - 4.6)
Positive
23 Jan 2025
Phase 2
30
rzrqzahumq(ivklidjnpq) = not reached phkxpovyei (pvoertwcju )
Positive
23 Jan 2025
Phase 2
30
Anlotinib + TACE
nroucuhfea(bxpmpzdaty) = tgutiqkmsq dhexucbjni (ycktefhemk, 50.2 - 85.6)
Positive
23 Jan 2025
Phase 2
30
Anlotinib + Penpulimab + Nab-paclitaxel
yodlasmvzl(tttczhdjwa) = gnoyltmhzv aqpererzmr (cdmiyewmnt, 7.57 - 14.11)
Positive
23 Jan 2025
Not Applicable
128
Anlotinib + Radiotherapy
nvlhbfdzzb(zscxusmhzx) = bmpcemewvc wvdiwxkeuf (uxlizgfasg, 72.5 - 96.7)
Positive
23 Jan 2025
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