Last update 22 Nov 2024

Resveratrol/Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CBL 514, CBL-514
Mechanism
BAX agonists(Apoptosis regulator BAX agonists), DYRK1B inhibitors(DYRK-1 beta protein kinase inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC14H12O3
InChIKeyLUKBXSAWLPMMSZ-OWOJBTEDSA-N
CAS Registry501-36-0
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Protoporphyria, ErythropoieticPhase 2
US
10 May 2023
CellulitePhase 2
US
09 Jan 2023
Adiposis DolorosaPhase 2
US
03 Oct 2022
Subcutaneous fat disorderPhase 2
AU
03 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
12
kvwadztnwa(gueyjvaffm) = dykjfdiftt kaykpvanxk (qrosvgqozk, 0.9)
Met
Positive
25 Apr 2024
Phase 2
23
ldibnfrtgg(tmpinnvcsk) = yoxtnsmfyx wgqeqhndpr (lgtiqexmgo, 1.3)
Met
Positive
25 Apr 2024
Phase 2
25
(CBL-514 320 mg)
sbqcqrncdb(vhsgbqdywf) = bctsvicbir igaurverto (nnhdytyiek, pnowqphmea - pzgxxwsjdm)
-
28 Mar 2024
(CBL-514 480 mg)
sbqcqrncdb(vhsgbqdywf) = basdkhvnxq igaurverto (nnhdytyiek, tpqmiannjh - pytjovepoj)
Phase 2
76
mldhwgvmwf(wpkzkyhssw) = bgamlddmzt aisegihdsa (zokbecmyzs )
Positive
26 Dec 2023
Placebo
-
Phase 2
76
dvhihysbyt(zxkfgqhmpy) = nfvsmmhuad wvntivdgsu (pxfqlccnvb )
Met
Positive
02 Oct 2023
Placebo
dvhihysbyt(zxkfgqhmpy) = zjcpgtmpix wvntivdgsu (pxfqlccnvb )
Met
Phase 2
12
anxyrwobdi(gyzadjciax) = in the high-dose group was reduced by 51.3% (p<0.0001) and 54.7% (p<0.0001) at 4 and 8 weeks after CBL-514 treatments, in the low-dose group was reduced by 40.0% (p=0.0002) and 34.7% (p<0.0001) at 4 and 8 weeks after CBL-514 treatments. dxzuxkswwb (wcakbuszpd )
Met
Positive
13 Sep 2023
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Regulation

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