Delving into the Latest Updates on Cisplatin/Glutathione with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Glutathione/cisplatin, Glutoxim, BAM-002

+ [1]

Target-

Action-

Mechanism

DNA alkylating agents

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication

Advanced Lung Non-Small Cell CarcinomaBreast CancerLeukemia+ [4]

Originator Organization

Cellectar Biosciences, Inc.

Active Organization

Sleep Number Labs

Inactive Organization

Cellectar Biosciences, Inc.Novelos Therapeutics, Inc.

License Organization-

Drug Highest PhaseApproved

First Approval Date

Russia (03 Jul 2001),

Neoplasms

Regulation-

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Structure/Sequence

Molecular FormulaC10H17N3O6S

InChIKeyRWSXRVCMGQZWBV-WDSKDSINSA-N

CAS Registry70-18-8

View All Structures (2)

RATIONALE: Oxidized glutathione (NOV-002) may stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving NOV-002 together with chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
PURPOSE: This phase II trial is studying how well giving oxidized glutathione (NOV-002) together with doxorubicin and cyclophosphamide followed by docetaxel works in treating women with newly diagnosed stage II or stage III breast cancer.

Start Date04 Jun 2007

Sponsor / Collaborator

University of Miami

NCT00347412

/ CompletedPhase 3

Phase 3 Trial, Randomized, Open-Label, of NOV-002 in Combination With Paclitaxel and Carboplatin vs. Paclitaxel and Carboplatin Alone for the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC)

The purpose of this clinical trial is to find out whether or not the combination of NOV-002 with chemotherapy (paclitaxel and carboplatin) is better at improving overall survival time when compared to chemotherapy alone in people with non-small cell lung cancer (NSCLC).
Earlier clinical trials in NSCLC showed that patients treated with NOV-002 in combination with chemotherapy had a better response (their tumors got smaller in one United States Phase 1/2 trial) than patients who received chemotherapy alone; and in two Phase 2 trials done in Russian patients, at the end of one year, patients treated with NOV-002 with chemotherapy had a better survival rate than patients who did not receive NOV-002 with their chemotherapy.

Start Date01 Nov 2006

Sponsor / Collaborator

Cellectar Biosciences, Inc.

NCT00345540

/ CompletedPhase 2

Phase 2 Trial of NOV-002 With Carboplatin in Women With Recurrent and Platinum Resistant Tumors of Mullerian Origin

The purpose of this trial is to determine the tumor response rate of NOV-002 plus carboplatin in a cohort of women with platinum resistant cancer of ovarian origin.

Start Date01 Jul 2006

Sponsor / Collaborator

Cellectar Biosciences, Inc.

[+2]

100 Clinical Results associated with Cisplatin/Glutathione

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100 Translational Medicine associated with Cisplatin/Glutathione

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100 Patents (Medical) associated with Cisplatin/Glutathione

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54

Literatures (Medical) associated with Cisplatin/Glutathione

01 Dec 2020·Bulletin of experimental biology and medicineQ4 · MEDICINE

Human Diploid Fibroblast Cell Lines — a Model System for Studying Immunodulatory Properties of Modern Immunobiological Drugs and Viruses

Q4 · MEDICINE

Article

Author: Kozhevnikova, T N ; Ozherelkov, S V ; Ivanova, A L ; Vorovich, M F ; Sanin, A V ; Konyuschko, O I ; Sotskova, S E ; Ishmuhametov, A A

The immunomodulatory properties of immunobiological drugs Glutoxim and Phosprenyl we well as vesicular stomatitis virus and inactivated tick-borne encephalitis vaccine virus were studied using human diploid fibroblast cell line from the collection of M. P. Chumakov Federal Research Center for Research and Development of Immunobiological Products. All tested preparations exhibited immunomodulatory activity in human diploid fibroblast cell line. Glutoxim in doses of 0.1 and 0.25 μg/ml stimulated production of IL-6 and IL-10 during 24-48 h of culturing, but did not stimulate production of IL-1β. Phosprenyl, on the contrary, increased production of IL-1β and the levels of IL-6 and IL-10. Vesicular stomatitis virus stimulated the production of IL-1β, IL-6, and IL-10, while inactivated tick-borne encephalitis vaccine virus stimulated the production of cytokines IL-8 and IL-18. Immunomodulatory activity of inactivated tick-borne encephalitis vaccine virus was first demonstrated in the in vitro system.

01 Jan 2020·Doklady. Biochemistry and biophysicsQ4 · BIOLOGY

Neuroleptic Chlorpromazine Modulates Ca2+ Responses in Macrophages

Q4 · BIOLOGY

Article

Author: Milenina, L S ; Krutetskaya, Z I ; Nozdrachev, A D ; Antonov, V G

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist neuroleptic chlorpromazine significantly inhibits glutoxim- and molixan-induced Ca²⁺ responses and Ca²⁺ responses induced by endoplasmic reticulum Са²⁺-ATPase inhibitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca²⁺ concentration increase and in the regulation of store-dependent Ca²⁺ entry in macrophages.

01 Jan 2019·Doklady. Biochemistry and biophysicsQ4 · BIOLOGY

Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin

Q4 · BIOLOGY

Article

Author: Melnitskaya, A V ; Krutetskaya, Z I ; Nozdrachev, A D ; Antonov, V G

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na⁺ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na⁺ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na⁺ transport in frog skin epithelium by glutoxim.

100 Deals associated with Cisplatin/Glutathione

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	L01XY	DB05393

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Neoplasms	Russia	Sleep Number Labs	03 Jul 2001

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Non-small cell lung cancer stage IIIB	Phase 3	Italy	Novelos Therapeutics, Inc.	22 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	United States	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Canada	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Israel	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Poland	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Romania	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Russia	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Serbia	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Spain	Cellectar Biosciences, Inc.	01 Nov 2006
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Switzerland	Cellectar Biosciences, Inc.	01 Nov 2006

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00345540 (CTgov)	Phase 2	Ovarian Cancer \| Platinum-Resistant Ovarian Carcinoma	15	Carboplatin+NOV-002	byrmkqwodi = ctolejteub ebckujuyay (sthcommwqz, ltfapdxiyi - cmfxatwyeg) View more	-	10 Mar 2015
NCT00499122 (CTgov)	Phase 2	Breast Cancer \| Invasive Mammary Carcinoma	41	Cyclophosphamide+Doxorubicin+Docetaxel+NOV 002	ecpqzfcesr(macrzcfpys) = zkiswkikgn sqmvxhghuy (jtmrnmokse, wrydjjptpm - xysckhuptm) View more	-	29 Mar 2013
Pubmed \| Breast Cancer Res Treat	Phase 2	HER2-negative breast cancer Neoadjuvant HER-2 negative	-	NOV-002	safizcjtml(umnnyjfaiz) = fpbexiqonu wbotqaggfy (ydltwmnfuc )	-	01 Feb 2012
ASCO2010	Phase 3	Advanced Lung Non-Small Cell Carcinoma	903	NOV-002 + paclitaxel + carboplatin	cjtxoizvyz(ierrwhkdda) = ucvsfnmvxw pgbzjyhmmy (kxsxvzontw ) View more	Negative	20 Jun 2010
ASCO2010	Phase 3	Advanced Lung Non-Small Cell Carcinoma	903	paclitaxel + carboplatin	cjtxoizvyz(ierrwhkdda) = zoehedjrap pgbzjyhmmy (kxsxvzontw ) View more	Negative	20 Jun 2010
AACR2007	Phase 3	Nephrotoxicity	-	Cisplatin + NOV-002	ukkxzaktnw(lpbrxkrfos) = lhhdtglmtl zsyvqvzyid (uoysdygyry ) View more	-	01 May 2007
ASCO2006	Phase 1/2	Advanced Lung Non-Small Cell Carcinoma First line	44	NOV-002 + carboplatin and paclitaxel (i.m.)	inhkgtrwfx(ouijpopclx) = lggwjmdsks figymadgse (ihhkrpsnrl ) View more	Positive	20 Jun 2006
ASCO2006	Phase 1/2	Advanced Lung Non-Small Cell Carcinoma First line	44	NOV-002 + carboplatin and paclitaxel (s.c.)	inhkgtrwfx(ouijpopclx) = ijprvzmycs figymadgse (ihhkrpsnrl ) View more	Positive	20 Jun 2006