Delving into the Latest Updates on Elemene with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

Dalianhualijingang Pharmaceutical Co. Ltd.

Active Organization

Dalianhualijingang Pharmaceutical Co. Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

China (01 Jan 1996),

Neoplasms

Regulation-

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Structure/Sequence

Molecular FormulaC15H24

InChIKeyOPFTUNCRGUEPRZ-QLFBSQMISA-N

CAS Registry515-13-9

The goal of this phase II randomized clinical trial is to compare the safety and efficacy of Elemene plus Stupp Protocol (the new protocol) and Stupp Protocol alone (the standard protocol) in patients with newly-diagnosed glioblastomas (ndGBMs). The main questions to answer are:
Whether the new treatment protocol (Elemene plus Stupp Protocol) is clinically safe for ndGBM patients.
Whether the new treatment protocol (Elemene plus Stupp Protocol) brings better survival benefits for ndGBM patients compared to the standard-of-care Stupp Protocol.
Study participants will be enrolled in 5 hospitals in China and randomly assigned to receive either the new protocol or the standard protocol. The overall survival (OS) rate in the 12th month, the progression-free survival (PFS) rate in the 6th month, OS, PFS, and adverse events assessed by the CTCAE (Common Terminology Criteria for Adverse Events) will be evaluated for all patients.

Start Date01 May 2023

Sponsor / Collaborator

Peking Union Medical College Hospital

NCT04674527

/ Unknown statusPhase 2IIT

A Pilot Study of Elemene Injectable Emulsion in Treating Patients With Refractory Glioblastoma

This is a pilot phase I study to evaluate the safety and efficacy on elemene injectable emulsion in treating patients with glioblastoma. Elemene, isolated from the Chinese medicinal herb Curcuma wenyujin, was shown to exhibit antitumor activity in human and murine tumor cells in vitro and in vivo.Elemene injectable emulsion against malignant tumors was low. Therefore, the effect of Elemene injectable emulsion being used in clinical settings needs to be confirmed by further RCTs.

Start Date01 Jun 2021

Sponsor / Collaborator

Second Affiliated Hospital Zhejiang University College of

[+1]

ChiCTR2000037148

/ RecruitingNot ApplicableIIT

Clinical study of HIPEC combined with traditional Chinese medicine elemene in the treatment of advanced colorectal cancer

Start Date01 Sep 2020

Sponsor / Collaborator-

100 Clinical Results associated with Elemene

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100 Translational Medicine associated with Elemene

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100 Patents (Medical) associated with Elemene

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6,774

Literatures (Medical) associated with Elemene

01 Jun 2025·Biochemical Systematics and Ecology

HS-SPME-GC/MS analysis of the volatile components of the resins of different Commiphora Jacq. Species collected in Socotra Island

Author: Attorre, Fabio ; Garzoli, Stefania ; Frezza, Claudio ; De Vita, Daniela ; La Montagna, Dario

In this paper, the volatile phytochem. pattern of the resins of five Commiphora Jacq. species collected in Socotra Island was reported.Different populations were studied, some of which for the first time, by using head space-solid phase microextraction (HS-SPME) sampling technique to collect the volatiles emitted from these species.All the captured volatile compounds in the accessions were identified and quantified by means of Gas-Chromatog./Mass Spectrometry (GC/MS).The obtained results highlighted the presence of terpene compounds, mainly monoterpenes and sesquiterpenes, which followed a different trend among the studied species in accordance with the ecol. of the collection areas of the species.Sesquiterpenes were predominant in C. kua and, in part, in C. ornifolia; monoterpenes were predominant in C. planifrons and C. parvifolia, whereas oxygenated monoterpenes were predominant in C. socotrana.A high number of the so-called other volatile components were found in C. planifrons.The dominant compounds were γ-cadinene in both accessions of C. kua, β-eudesmol in the first accession of C. ornifolia and δ-cadinene in its second accession, limonene in both accessions of both C. planifrons and C. parvifolia, terpinen-4-ol in both accessions of C. socotrana.The meaning of the data was considered under the chemophenetic, ecol. and ethnobotanical aspects.

01 Jun 2025·Biochemical Systematics and Ecology

Population variability of volatile secondary metabolites in Hypericum aviculariifolium subsp. depilatum var. depilatum

Author: Seyis, Fatih ; Cirak, Cuneyt

Chem. analyses of flowering tops of eleven wild populations of Hypericum aviculariifolium subsp. depilatum var. depilatum (Hypericaceae), an endemic species of Turkish flora, identified 25 to 36 volatile secondary metabolites (VSM).Oxygenated monoterpenes such as linalool, camphor and verbenol and sesquiterpenic hydrocarbons such as β-selinene, γ-cadinene and β-caryophyllene were recognized as the main ingredients across populations.This is the first report documenting the variability of volatile secondary metabolites among wild populations of this endemic species.Data acquired were also discussed in terms of their possible chemotaxonomic significance.

01 May 2025·Food Chemistry

Long-term study of Citrus changshan-huyou Y.B. Chang essential oil: Chemical transformations and their impact on antibacterial efficacy

Article

Author: Xiao, Wenbin ; Liu, Ting ; Guo, Jiajing ; Li, Gaoyang ; He, Mingwang ; Fu, Fuhua ; Li, Zixuan ; Shang, Xuebo ; Fu, Yanjiao ; Gao, Zhipeng ; Xiao, Yangbo ; Su, Donglin ; Shan, Yang ; Zhang, Tongping

The essential oil from Citrus changshan-huyou Y.B. Chang (HYEO) contains volatile compounds with strong inhibitory effects on biofilms formed on food processing equipment. This study analyzed the compositional changes of HYEO over 9 years and evaluated its antibacterial and antibiofilm properties. HYEO showed significant antibacterial activity during the first 8 years, effectively removing mature biofilms. Gas chromatography-mass spectrometry analysis revealed that monoterpenes were the primary components, with d-limonene and γ-terpenes converting into oxygenated derivatives during storage, resulting in a more than 16-fold increase in antibacterial activity. The antibacterial strength correlated with the number of oxygenated derivatives from limonene and terpinene among the top 20 components. Significant associations were observed between antibacterial activity and the oxygenated derivatives of d-limonene and γ-terpenes. These findings suggest the need for further investigation into their synergistic effects, antibacterial mechanisms, potential applications in food processing, and the safety profiles of the main antibacterial components of HYEO.

100 Deals associated with Elemene

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Elemene	L01XX	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Neoplasms	China	Dalianhualijingang Pharmaceutical Co. Ltd.	01 Jan 1996

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


CSCO2022	Not Applicable	Malignant ascites	42	榄香烯乳状注射液	zqnumlxoam(gugtfaityr) = fapfrcufxr fcpzvgkymi (wpqvpteurs )	Positive	21 Sep 2022
CSCO2021	Not Applicable	Esophageal Carcinoma	50	榄香烯 (单放组)	ksbfwsjxqk(rxjstvuolv) = xsuoibwhqz isolqielui (ahhqhbhayt ) View more	-	25 Sep 2021
				榄香烯 (综合组)	ksbfwsjxqk(rxjstvuolv) = auyqkerezj isolqielui (ahhqhbhayt ) View more
CSCO2021	Not Applicable	-	65	榄香烯注射液联合TMZ(替莫唑胺)	jrtlycwqys(wjkdkxyywj) = qfwjxkiqnh fkpwtashoi (ciuucmmsmm )	Positive	25 Sep 2021
				单TMZ组	jrtlycwqys(wjkdkxyywj) = aiexkfcnob fkpwtashoi (ciuucmmsmm )
CSCO2021	Not Applicable	Liver Cancer	60	榄香烯注射液联合放疗	uwxcqeofkr(hsxgxvonjh) = mqdknvdjfr xhczgccqgm (mqpuhwjhne ) View more	Positive	25 Sep 2021
				榄香烯注射液 (单纯放疗)	uwxcqeofkr(hsxgxvonjh) = wdxurudcqb xhczgccqgm (mqpuhwjhne )
CSCO2021	Not Applicable	HER2 negative Gastric Cancer	66	榄香烯口服乳+奥沙利铂+替吉奥	(ytzikqjudi) = vcmqwluytg crycxlunjt (vuejigdpvz ) View more	Positive	25 Sep 2021
				奥沙利铂+替吉奥	(ytzikqjudi) = rqvnlgljzz crycxlunjt (vuejigdpvz ) View more
CSCO2020	Not Applicable	Hypopharyngeal Carcinoma	56	榄香烯口服乳	blfqoqeodd(rrbfsqdneq) = opvimkwaiq pylnatbahr (drvjqgozzs ) View more	Positive	19 Sep 2020
				同步放化疗	blfqoqeodd(rrbfsqdneq) = nnbkvgifwe pylnatbahr (drvjqgozzs ) View more
CSCO2020	Not Applicable	Liver Cancer	60	榄香烯注射液联合介入化疗	cbuvajwbbc(mnukmqnnpb) = 榄香烯组明显减轻，两组比较差异有统计学意义(P<0.05) eysioalduj (kezgkayosg ) View more	-	19 Sep 2020
				榄香烯注射液 (介入化疗)
CSCO2020	Not Applicable	Malignant ascites	42	腹腔灌注榄香烯注射液	mnrplqwttb(rghwmyblpc) = kejatosklh zkieiwgllg (oymffsenzu )	Positive	19 Sep 2020
CSCO2020	Not Applicable	Advanced gastric carcinoma	50	榄香烯口服乳	(vktmsufjqr) = nsumxmtdgj nnltyrfnsw (xtfingnjqk ) View more	Positive	19 Sep 2020
				榄香烯 (最佳支持治疗)	(vktmsufjqr) = sipwvblxdl nnltyrfnsw (xtfingnjqk )
CSCO2020	Not Applicable	Non-Small Cell Lung Cancer \| Brain metastases	90	榄香烯注射液联合全脑放疗	nhkvzzlwwv(cpuwllwxaj) = tzuafqosan nhyoonhqwl (edrzjpjeia ) View more	-	19 Sep 2020
				榄香烯注射液 (全脑放疗)	nhkvzzlwwv(cpuwllwxaj) = ptupvfnkvf nhyoonhqwl (edrzjpjeia ) View more