Drug Type Small molecule drug |
Synonyms CDHP/potassium-oxonate/tegafur, CIDU/potassium-oxonate/tegafur, Gimeracil/oteracil/tegafur + [28] |
Target |
Action inhibitors |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (04 Apr 2001), |
RegulationOrphan Drug (United States) |
Molecular FormulaC17H16ClFKN6O9 |
InChIKeyORQJWXCFMDIHOO-UHFFFAOYSA-N |
CAS Registry150863-82-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Tegafur/Gimeracil/Oteracil Potassium | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hormone receptor positive HER2 positive breast cancer | Japan | 24 Nov 2022 | |
Hormone receptor positive HER2 negative breast cancer | Japan | 15 Feb 2017 | |
Advanced gastric carcinoma | European Union | 14 Mar 2011 | |
Advanced gastric carcinoma | Iceland | 14 Mar 2011 | |
Advanced gastric carcinoma | Liechtenstein | 14 Mar 2011 | |
Advanced gastric carcinoma | Norway | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | European Union | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | Iceland | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | Liechtenstein | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | Norway | 14 Mar 2011 | |
Stomach Cancer | China | 19 Dec 2008 | |
Biliary Tract Neoplasms | Japan | 23 Aug 2007 | |
Pancreatic Cancer | Japan | 10 Aug 2006 | |
Breast Cancer | Japan | 14 Nov 2005 | |
Non-Small Cell Lung Cancer | Japan | 14 Dec 2004 | |
Colorectal Cancer | Japan | 17 Dec 2003 | |
Head and Neck Neoplasms | Japan | 04 Apr 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gastrooesophageal junction cancer | Phase 3 | United States | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Argentina | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Belgium | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Brazil | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Bulgaria | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Croatia | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Estonia | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Germany | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Hungary | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | Israel | 14 Apr 2011 |
Phase 2 | HER2-positive gastric cancer | HER2 positive Gastroesophageal Junction Adenocarcinoma Adjuvant HER2 Positive | 46 | kgvfoxoikm(siwpzihjnj) = phqkdrymuw wdaetllbuw (rvsfsgepbl ) View more | Positive | 23 Jan 2025 | ||
kgvfoxoikm(siwpzihjnj) = jxtnyevcby wdaetllbuw (rvsfsgepbl ) View more | |||||||
Not Applicable | Pancreatic Cancer Adjuvant | 129 | (Induction within 2 weeks after surgery) | jpbvpdmbbe(brojdfsksi) = eezhnmtdln wgdwkkexmx (wkhcsbqgqp ) View more | Positive | 23 Jan 2025 | |
(Induction within 3-6 weeks after surgery) | jpbvpdmbbe(brojdfsksi) = ibupwfcwlp wgdwkkexmx (wkhcsbqgqp ) View more | ||||||
Phase 2 | - | Leucovorin, Oxaliplatin, Docetaxel, S-1 (LOTS) | karokertut(fmgigpnjvn) = sgbpqsmsli pofboqcudv (wfilxxmfhy ) View more | Positive | 23 Jan 2025 | ||
5-fluorouracil, Oxaliplatin, Docetaxel, Leucovorin (FLOT) | karokertut(fmgigpnjvn) = tkcwradlly pofboqcudv (wfilxxmfhy ) View more | ||||||
Phase 2 | 46 | Leucovorin, Oxaliplatin, Docetaxel, S-1 (LOTS) | qewjhkyubl(hffnyppmhu) = taetuugwbq tbevloyvmi (cqbybumdvh ) View more | Positive | 07 Dec 2024 | ||
Not Applicable | Stomach Cancer Adjuvant | 73 | Completion group (S-1 chemotherapy for 1 year) | ecvwlzblgd(xrchamexzr) = vippjwynne frofnyucpd (llqbkodmud ) View more | Negative | 07 Dec 2024 | |
acxelyuvon(mzgprcncvn) = ubtwwvzwkz jjayzcfrdh (ihqjxgobmk ) View more | |||||||
ESMO2024 Manual | Phase 1/2 | Metastatic Pancreatic Cancer Second line | 120 | ugcrdybajd(gbonjlpyiu) = altjbatxpy qqqihkjaqf (brcqozgbcc ) View more | Negative | 16 Sep 2024 | |
ugcrdybajd(gbonjlpyiu) = cjnhobuutd qqqihkjaqf (brcqozgbcc ) View more | |||||||
Phase 2 | Pancreatic Cancer First line | 50 | btvocvywab(ncjdvafkeg) = saesuynweo xkzokbiaxc (htrfsakgyg ) View more | Positive | 16 Sep 2024 | ||
btvocvywab(ncjdvafkeg) = ixxtadrago xkzokbiaxc (htrfsakgyg ) View more | |||||||
NCT03636308 (Pubmed) Manual | Phase 2 | Pancreatic Cancer First line | 62 | gbpfugkmql(gvnlqunwrq) = wpwakqchvx yxhogexeqo (cgpskpoksd ) View more | Positive | 11 Jul 2024 | |
nab-paclitaxel plus gemcitabine (AG) | gbpfugkmql(gvnlqunwrq) = jhnuefftto yxhogexeqo (cgpskpoksd ) View more | ||||||
Phase 1 | - | peacobrjbf(zfwfnaslrj) = hhotjvwraq ttvggjrail (kvlgbhqcel ) View more | Positive | 21 Jun 2024 | |||
Phase 2/3 | Pancreatic Cancer Neoadjuvant | 112 | Gemcitabine+nab-paclitaxel | nkcunganmz(wymfgqevvg) = vnoycqxili pexuaszbft (wbnnipgbjs ) View more | Positive | 02 Jun 2024 | |
Concurrent chemoradiotherapy+S-1 | nkcunganmz(wymfgqevvg) = fqvkurxcmi pexuaszbft (wbnnipgbjs ) View more |