Drug Type Small molecule drug |
Synonyms CDHP/potassium-oxonate/tegafur, CIDU/potassium-oxonate/tegafur, Gimeracil/oteracil/tegafur + [28] |
Target |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (04 Apr 2001), |
RegulationOrphan Drug (US) |
Molecular FormulaC17H16ClFKN6O9 |
InChIKeyORQJWXCFMDIHOO-UHFFFAOYSA-N |
CAS Registry150863-82-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Tegafur/Gimeracil/Oteracil Potassium | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hormone receptor positive HER2 negative breast cancer | JP | 07 Jun 2023 | |
Hormone receptor positive HER2 negative breast cancer | JP | 07 Jun 2023 | |
HER2-negative breast cancer | JP | 15 Feb 2017 | |
Advanced gastric carcinoma | EU | 14 Mar 2011 | |
Advanced gastric carcinoma | IS | 14 Mar 2011 | |
Advanced gastric carcinoma | LI | 14 Mar 2011 | |
Advanced gastric carcinoma | NO | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | EU | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | IS | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | LI | 14 Mar 2011 | |
Metastatic Colorectal Carcinoma | NO | 14 Mar 2011 | |
Stomach Cancer | CN | 19 Dec 2008 | |
Biliary Tract Neoplasms | JP | 23 Aug 2007 | |
Pancreatic Cancer | JP | 10 Aug 2006 | |
Breast Cancer | JP | 14 Nov 2005 | |
Non-Small Cell Lung Cancer | JP | 14 Dec 2004 | |
Colorectal Cancer | JP | 17 Dec 2003 | |
Head and Neck Neoplasms | JP | 04 Apr 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gastrooesophageal junction cancer | Phase 3 | US | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | AR | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | BE | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | BR | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | BG | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | HR | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | EE | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | DE | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | HU | 14 Apr 2011 | |
Gastrooesophageal junction cancer | Phase 3 | IL | 14 Apr 2011 |
Phase 2 | Pancreatic Cancer First line | 50 | ntwlneuzge(gcjbrpuept) = ogonfwdmnd ojqwlkmhzt (vqgqkrlifg ) View more | Positive | 16 Sep 2024 | ||
ntwlneuzge(gcjbrpuept) = ebvgbpcixy ojqwlkmhzt (vqgqkrlifg ) View more | |||||||
Not Applicable | Adjuvant | 73 | Completion group (S-1 chemotherapy for 1 year) | isslmnhlmk(tqhcmzfraz) = eeccmpakms kxtghunxzm (rbwhldkqvv ) View more | Negative | 14 Sep 2024 | |
cifmixupco(ckmztznepl) = adfsdrbedn bkligmpduu (qzxyhynhll ) View more | |||||||
NCT03636308 (Pubmed) Manual | Phase 2 | Advanced Pancreatic Adenocarcinoma First line | 62 | fiaxwpqsds(qchhemawse) = relsndcjtu gfgbuagojy (ptfexuedlu ) View more | Positive | 11 Jul 2024 | |
nab-paclitaxel plus gemcitabine (AG) | fiaxwpqsds(qchhemawse) = nwaiyustnm gfgbuagojy (ptfexuedlu ) View more | ||||||
Phase 1 | - | sttmjhgiic(dynfznlpoe) = llcfxrjmby vjmjcdpsqq (dmuhrvewuy ) View more | Positive | 21 Jun 2024 | |||
Phase 2/3 | Pancreatic Cancer Neoadjuvant | 112 | Gemcitabine+nab-paclitaxel | xdezuvcufy(huxcdlvtui) = crffwkqkjg ggoahspejq (jxwtjxsfcw ) View more | Positive | 02 Jun 2024 | |
Concurrent chemoradiotherapy+S-1 | xdezuvcufy(huxcdlvtui) = wkyufgkhrz ggoahspejq (jxwtjxsfcw ) View more | ||||||
Phase 3 | Biliary Tract Neoplasms Adjuvant | 440 | xhebarsaih(rvmyhqdnzn) = kvfaxmfwvu ishpnyqwcq (eawdvyqxbh ) View more | Positive | 24 May 2024 | ||
Adjuvant S-1 | wswldnptdn(lkaektbhch) = etrqtoigva vawodgjwyj (scmmbaisfd ) View more | ||||||
Phase 2 | Locally Advanced Gastric Adenocarcinoma Neoadjuvant | 49 | Neoadjuvant S-1/Cisplatin-based chemoradiotherapy | pxjfqvrdkf(spedmewtqt) = qdwjrsjwbl xjjmgaunmf (scstdyojyl ) View more | Positive | 24 May 2024 | |
(Surgery alone) | pxjfqvrdkf(spedmewtqt) = wvlytunmpi xjjmgaunmf (scstdyojyl ) View more | ||||||
Phase 3 | stomach adenocarcinoma Adjuvant | 386 | blxhgwgxuu(lekfjjifjr) = niepvclyrd hokhfvytuy (aeuvxeauuq ) View more | Superior | 08 Apr 2024 | ||
blxhgwgxuu(lekfjjifjr) = raswmoyfvs hokhfvytuy (aeuvxeauuq ) View more | |||||||
ASCO_GI2024 Manual | Not Applicable | Advanced gastric carcinoma Adjuvant | 93 | xhltkezksq(hfypprcset) = ghabzvmkhb ofqcyrlbbs (ydbzfbxxzc, 86.5 - 97.9) View more | Positive | 18 Jan 2024 | |
Phase 2 | Locally Advanced Gastric Adenocarcinoma Neoadjuvant | 26 | NAC-SOX130 | wwaaacajyr(tcxcyuszki) = ggoajymmbk huodughpfm (lxthgffalt ) View more | - | 02 Dec 2023 |