This will be a placebo-controlled, multicenter-randomized prospective study of CPLE (Carica papaya leaf extract) tabs in dengue patients (WHO-Group A, B). The study will enroll 300 eligible dengue cases into two arms: one arm receiving CPLE 1000mg t.i.d for 5 days and the other group receiving a placebo.
The main question to ask is whether CPLE reduces severe disease progression and increases platelet counts in dengue patients.
The participant will be asked to take orally available CPLE capsules at a dose of 1000 mg (2 capsules, 500mg each) or identical placebo three times a day for 5 days

Start Date01 Oct 2023

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

NCT05360134

/ Unknown statusNot ApplicableIIT

Efficacy and Safety of Platelet Augmentation Using Carica Papaya Leaf Extract in Live Donor Liver Transplantation Recipients - a Pilot Randomized Controlled Trial

This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant recipients. Carica Papaya leaf extract has shown positive results in increasing platelet counts in various medical conditions such as Dengue, Immune thrombocytopenic purpura and chemotherapy induced thrombocytopenia. Thrombocytopenia i.e. low platelet counts are a common occurrence in patients with chronic liver disease undergoing live donor liver transplant. It has been observed in previous studies that live donor liver transplant recipients who have persistent thrombocytopenia have significantly worse outcomes as compared to patients who have higher platelet counts. Positive results in this study lead to further studies in assessing the impact of platelet augmentation in live donor liver transplant recipients.

Start Date01 Jan 2021

Sponsor / Collaborator

Institute of Liver & Biliary Sciences

100 Clinical Results associated with Papaya Leaf Extract

100 Translational Medicine associated with Papaya Leaf Extract

100 Patents (Medical) associated with Papaya Leaf Extract

Literatures (Medical) associated with Papaya Leaf Extract

01 Feb 2025·Drug Research

A Review of Potentials of Carica Papaya Leaves in Dengue Viral Infection – Insights of Clinical and Preclinical Studies

Review

Author: Hussain, Mohamed Harshath Jahir ; Balasubramanian, Rajkapoor ; Gobinath, Mirunalini ; Shanmugam, Arun ; Maideen, Naina Mohamed Pakkir

AbstractOne of the most widespread arboviral diseases in the world, dengue virus disease (DVD) is primarily found in tropical and subtropical regions, affecting 129 countries. The main way that the dengue virus (DENV) spreads is through the bite of a female Aedes aegypti mosquito. Symptomatic therapy and supportive care are the primary methods of managing patients with DENV infection as there is currently no approved antiviral medication for this condition. Since the guidelines from the AYUSH Ministry, Government of India, recommend 10 ml of carica papaya leaf extract (CPLE) twice daily for seven days, to treat dengue fever clinically, we plan to review the potential of carica papaya in managing DENV infection.Using terms like dengue, dengue fever, dengue hemorrhagic fever, dengue shock syndrome, and carica papaya, the literature was searched in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of Science, EMBASE, Directory of open access journals (DOAJ), and reference lists to find articles relevant to the clinical, in-vivo, in-vitro, and in-silico studies evaluating the efficacy of carica papaya in the management of dengue viral infection. This review included English-language publications that supported the use of carica papaya in the treatment of dengue fever, but it excluded publications that were duplicates.Numerous preclinical and clinical investigations, such as in-vitro, in-vivo, and in-silico studies, have identified carica papaya's anti-dengue potential. The pleiotropic effects of carica papaya, including its anti-thrombocytopenic activity, immunomodulatory effects, and larvicidal property against the Aedes aegypti mosquito species, have also been confirmed by numerous in-vitro and in-vivo studies. These effects can help patients with dengue fever by elevating their platelet count and alleviating other symptoms.To hasten recovery and reduce hospital stays, patients with DENV infection may take carica papaya leaf extract (CPLE) in addition to supportive care and symptomatic treatment. Additional randomized controlled clinical trials would be necessary to confirm the safety and effectiveness of CPLE in patients with DENV infection.

01 Jun 2022·Journal of Family Medicine and Primary Care

Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients

Article

Author: Pambhar, Vivek ; Mathur, Medha ; Kumawat, Dal Chand ; Patyal, Ashish ; Verma, Anjana ; Mehta, Amit ; Mangalia, Ravi ; Mathur, Navgeet

ABSTRACTBackground:Dengue fever is a mosquito borne disease commonly manifest leucopoenia and thrombocytopenia. Dengue fever and its complications like bleeding manifestation can be life threatening. This study was conducted to study the effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopoenia in acute dengue fever patients.Methods:This case control study was conducted amongst the patients suffering from dengue fever with thrombocytopenia. Cases were dengue patients with thrombocytopenia and leucopenia both. Controls were dengue patients with thrombocytopenia with normal leukocyte count. An effect of doxycycline and doxycycline with carica papaya was observed on platelet and leukocyte counts at baseline and first, second, fourth, and seventh day in cases and comparison was done.Results:The maximum improvement in mean platelet count and leukocyte count was observed in doxycycline with carica papaya group followed by doxycycline alone group followed by controls (conservative treatment) in decreasing order on day 4th and 7th day of admission. Reduced hospital stay was also in the same order.Conclusion:The study results indicate that doxycycline and carica papaya are useful modality to improve leucopenia and thrombocytopenia in dengue patients and to minimize hospital stay.

01 Mar 2010·Tropical Animal Health and ProductionQ3 · AGRICULTURAL & FORESTRY SCIENCE

A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Martha N. Musukwa ; Andrew M. Phiri ; Amos Chota ; Felix Haazele ; Isaac K. Phiri ; Chummy Sikalizyo Sikasunge

Village chickens play vital roles in the livelihoods of those people keeping them. Backyard poultry provide a critical source of food and income for people in developing countries (Lans et al. 2007) and so is the case in Zambia. However, their productivity has been hampered by many constraints resulting in low flock sizes (Kusina and Kusina 1999). Among the constraints is the problem of external and internal parasites (Abebe et al. 1997). In Africa, the control of these parasites is limited by the high cost of anthelmintics, their uncertain availability and the increasing frequency of drug resistance (Naidoo et al. 2008). Therefore, possible alternatives such as the use of plant products that function by mechanisms other than those of chemotherapeutics, with the additional advantage of a natural origin have been recommended (Naidoo et al. 2008). Besides, the cost of treatment with alternative traditional methods (herbs) is negligible when compared with the cost of conventional medicines. In addition to being very inexpensive, herbal preparations have good medicinal value (Mbaria et al. 1998). Therefore, in a quest for provision of safe animal products, a number of studies on use of herbal therapy especially in poultry, have been conducted many of which have reported a number of herbal products that are of potential use as therapeutic or prophylactic agents against bacteria (Arshad et al. 2008), protozoa (Nweze and Obiwulu 2009; Naidoo et al. 2008; Arshad et al. 2008) and viruses (Kong et al. 2006). However, only a few herbal products (Lans et al. 2007; Purwati and He 1991) have been reported to be potential antihelmintic agents in poultry. The objective of the current study was to compare the efficacy of Carica papaya latex with that of piperazine in the control of nematode parasites in village chickens as well as assess the effect of treatment on productivity (weight gain). Trop Anim Health Prod DOI 10.1007/s11250-009-9432-6

100 Deals associated with Papaya Leaf Extract

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Indication	Highest Phase	Country/Location	Organization	Date
Dengue	Phase 3	Bangladesh	Bangabandhu Sheikh Mujib Medical University	01 Oct 2023

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Pubmed \| Food Chem Toxicol	Not Applicable	Vomiting of pregnancy \| Wounds and Injuries	-	Carica papaya epicarp extracts	dcuyvqzotz(zmfcuukfqt) = hhukkochqp ovbrylgnrv (sodsdjrmxl )	-	01 Jul 2008
				Carica papaya epicarp extracts	mxcydftkpa(sxrassrolr) = cncwgxtggb ihmflhmscs (pcmymwchaf ) View more
Pubmed	Not Applicable	-	-	Carica papaya L.	idwcrjcxhe(vigfhciklk) = The extract treated wounds were found to epithelize faster as compared to controls ybgjqqksiw (zizdelfily )	Positive	01 Aug 2007
				Carica papaya L.

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