Last update 08 May 2025

L-9LS

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
VRC-MALMAB0114-00-AB
Target
Action
inhibitors
Mechanism
PfCSP inhibitors(Plasmodium falciparum circumsporozoite protein inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication-
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
MalariaPhase 2
Mali
18 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
490
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-
02 Apr 2025
Placebo
(Placebo)
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Phase 2
365
(Adult Dose-escalation Study: Arm 1: 300 mg of L9LS)
(stgngvfkqf) = fsmfxywtxe rtgnzcncwt (snlzklxbug, cxejrrzadn - biwxouxphl)
-
10 Jul 2024
(Adult Dose-escalation Study: Arm 2: 600 mg of L9LS)
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Phase 2
225
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Positive
26 Apr 2024
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Phase 1
32
Plasmodium falciparum (P. falciparum) sporozoite challenge+VRC-MALMAB0114-00-AB
(Group 1: L9LS (1 mg/kg IV))
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-
13 Oct 2023
Plasmodium falciparum (P. falciparum) sporozoite challenge+VRC-MALMAB0114-00-AB
(Group 2: L9LS (5 mg/kg IV))
atzbxpqoei(plrflyafub) = saxiglaiyg kximmqnero (fcuxmkrpnq, lnbgauxxpm - dybawixhdf)
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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