Delving into the Latest Updates on Sodium metaarsenite with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

KOMINOX, PANAPHIX, Sodium metaarsenite

+ [3]

Target

Telomerase

Action

inhibitors

Mechanism

Telomerase inhibitors

Therapeutic Areas

NeoplasmsRespiratory Diseases

Active Indication-

Inactive Indication

Advanced Lung Non-Small Cell Carcinoma

Originator Organization

Komipharm

Active Organization-

Inactive Organization

University of Maryland Baltimore

License Organization-

Drug Highest PhaseDiscontinuedPhase 1

First Approval Date-

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaAsHNaO2

InChIKeyKPERHSNZLCSWJQ-UHFFFAOYSA-N

CAS Registry7784-46-5

Atm. arsenic pollution, primarily caused by non-ferrous metal smelting and coal combustion, poses a significant environmental challenge.The removal of gaseous As₂O₃ from flue gas has become an urgent priority.Compared to synthetic adsorbents, natural manganese minerals (NMMs) possess advantages such as abundant reserves, low cost, and strong arsenic affinity, making them a promising candidate for large-scale gaseous As₂O₃ removal applications.This study investigates the As₂O₃ capture behavior of various NMMs through a combination of experiments and d. functional theory (DFT) calculationsPyrolusite (PY, 14.67 mg/g) and Hausmannite (HA, 20.69 mg/g) demonstrate superior adsorption performance compared to conventional adsorbents such as CaO (6.28 mg/g), Al₂O₃ (10.91 mg/g), and Fe₂O₃ (11.45 mg/g).DFT calculations and characterization results confirm that the adsorption of gaseous As₂O₃ by NMMs is primarily governed by chemisorption, with lattice oxygen serving as the key factor influencing the adsorption process.Surface oxygen sites on HA and PY serve as the primary active sites for As₂O₃ adsorption, where As₂O₃ forms stable covalent bonds with HA and PY.During the adsorption of gaseous As₂O₃, lattice oxygen is gradually consumed, while Mn facilitates the oxidation of arsenic.The findings of this study suggest that certain NMMs can efficiently capture gaseous As₂O₃ from high-temperature industrial flue gas, laying the foundation for the large-scale industrial application of adsorption-based As₂O₃ removal methods.

01 May 2025·Journal of Colloid and Interface Science

Chirality engineering-regulated liquid–liquid phase separation of stress granules and its role in chemo-sensitization and side effect mitigation

Article

Author: Yu, Han ; Zheng, Liuting ; Ma, Ruxuan ; Huo, Da ; Zhao, Huiyue ; Zhang, Hao

In recent years, the chiral biological effects of nanomedicines have garnered significant interest. Research has focused on understanding how material chirality affects cellular transcription and metabolism. Stress granules, which are membraneless organelles formed through liquid-liquid phase separation of G3BP1 proteins and related compartments, have been extensively studied and are closely associated with cellular damage repair and metabolism. The role and mechanism of chiral nanomaterials in modulating stress granules remain unclear. This study aimed to investigate the expression and structural characteristics of stress granules under the influence of chiral nanomaterials, both individually and in combination with chemotherapy. A library of chiral ligand-modified materials was constructed, and techniques such as immunofluorescence, live-cell imaging, fluorescence recovery after photobleaching assays, and proximity labeling combined with proteomics analysis were employed. These methods helped identify the protein corona adsorbed on the surface of the nanomaterials and explore their relationship with nanomaterial chirality. The findings suggest that the assembly of stress granules is influenced by chirality and can be regulated by chiral nanomaterials. Additionally, chemotherapy sensitivity in cancer cells was enhanced, and normal cells were protected by leveraging the chiral-dependent modulation of material assembly in stress granules. This study offers insights into the regulation of membraneless cellular structures based on chiral biological effects.

01 Apr 2025·Ecotoxicology and Environmental Safety

Prioritizing endocrine-disrupting chemicals targeting systemic lupus erythematosus genes via Mendelian randomization and colocalization analyses

Article

Author: Gao, Sheng ; Shao, Chenyou ; Shu, Wanyi ; Wang, Yi ; Yang, Qianru ; Wang, Deqi ; Jiang, Xiaoyang ; Hua, Chunyan ; Chen, Rujie ; Hong, Yanggang

BACKGROUNDSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease, with both genetic and environmental influences contributing to its development. Among environmental factors, endocrine-disrupting chemicals (EDCs), present in plastics, pesticides, and personal care products, have been implicated in immune disruption. This study investigated the interactions between EDCs and SLE-associated genes to elucidate their role in SLE susceptibility.METHODSWe employed Mendelian randomization (MR) and colocalization analyses to explore genetic predispositions and environmental interactions in SLE. Cis-expression quantitative trait loci (cis-eQTL) data were obtained from the eQTLGen Consortium, and genome-wide association study (GWAS) data for SLE were acquired from the IEU Open GWAS database. MR analysis was performed to establish causal links between gene expression and SLE, and colocalization analysis was used to validate these associations.RESULTSOur analysis identified 18 genes causally associated with SLE. Among them, five genes (CDCA7, HOXA1, LRRC37A4P, HOXA5, and DND1P1) showed strong evidence of colocalization with SLE. Further, 28 EDCs, including bisphenol A, bisphenol S, and endosulfan, were found to interact with these key genes, potentially influencing immune function and exacerbating the genetic susceptibility to SLE.CONCLUSIONSThis study highlights the complex interactions between EDCs and genetic predisposition in SLE. The findings provide valuable insights into how environmental exposures, particularly EDCs, may contribute to the development and progression of autoimmune diseases like SLE. These results suggest potential targets for future therapeutic interventions and underscore the need for further research on gene-environment interactions in SLE.

100 Deals associated with Sodium metaarsenite

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