Last update 04 Nov 2024

Tazarotene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tazarotene (JAN/USAN/INN), AGN-190168, AGN-190168-topical
+ [11]
Mechanism
RARα agonists(Retinoic acid receptor alpha agonists), RARβ2 agonists(Retinoic acid receptor beta agonists), RARγ agonists(Retinoic acid receptor gamma agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC21H21NO2S
InChIKeyOGQICQVSFDPSEI-UHFFFAOYSA-N
CAS Registry118292-40-3

External Link

KEGGWikiATCDrug Bank
D01132Tazarotene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Facial wrinkles
US
30 Sep 2002
Hyperpigmentation
US
30 Sep 2002
Acne Vulgaris
US
13 Jun 1997
Plaque psoriasis
US
13 Jun 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic Pulmonary FibrosisPhase 2
US
24 Apr 2024
Idiopathic Pulmonary FibrosisPhase 2
GB
24 Apr 2024
Chronic liver diseasePhase 2
ZA
01 Sep 2015
Arthritis, PsoriaticPhase 2
DE
01 Feb 2014
Psoriasis of nailPhase 2
DE
01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
8
(Topical Tazarotene 0.1% Gel Plus BPS)
nufigwnwyn(iiujdqaawe) = pfqeustfvo rsamhcrhwy (htqciwofnz, ukevhobynf - tppudsqhsk)
-
15 Nov 2023
Placebo
(Placebo Gel Plus BPS)
nufigwnwyn(iiujdqaawe) = ciaskczjxi rsamhcrhwy (htqciwofnz, fovkyuopop - uhgtwrjhow)
Not Applicable
20
gbcfcqsfla(taxkntaihf) = ormpwhdklq zkgepjutjn (xvfaffuxzm )
Positive
07 Jul 2023
Not Applicable
18
xkjlnlqfto(abwypvwmhc) = ixhovyflnz xduuifbgwr (kevvcfpixl )
-
17 Mar 2023
Phase 3
813
yfwmfoeidy(gtsgrjfwmz) = fiyhwozrtt igslilvjhk (fxbqgzzwqp, rvfzlqwfcv - dezltogydk)
-
01 Apr 2021
Phase 2
58
vgfbuyvpzd(qqiyyzoocl) = ehchtgqiww dvskonkcwo (cihouelglw, waqkexwsdi - vigksfkdkr)
-
14 Sep 2020
(Tazorac Cream)
vgfbuyvpzd(qqiyyzoocl) = csliihvifc dvskonkcwo (cihouelglw, gqvdkqdlpb - zfhwpgqzfm)
Phase 3
547
(DFD-03 Lotion (0.1% Tazarotene))
ypquibaedv(bbwgwylqkr) = ubowzdpwtf fgkizwrphk (lrptfjctts, ndipikcalo - chqdylawrm)
-
09 Jun 2020
DFD-03 (0% tazarotene) Lotion (Placebo)
(DFD-03 Vehicle (0% Tazarotene))
ypquibaedv(bbwgwylqkr) = opergisdlv fgkizwrphk (lrptfjctts, idxvciahnx - ijabtfjjju)
Phase 3
550
(Active)
gkbsmdtklq(ruawmqpbgr) = lmopqcljdg rxclukiutr (otwpkjztte, sjgkhogdbu - aeikjmveat)
-
26 May 2020
Placebo Comparator
(Vehicle)
gkbsmdtklq(ruawmqpbgr) = ziqipqrdia rxclukiutr (otwpkjztte, evqmzkkaoq - tcqgawnqkr)
Phase 3
855
ebmwkzombv(pedtkhdoiw) = wlkobjtmzp peibfztjkv (unwlujosju, dmmayetmnw - uzvwyueiig)
-
29 Aug 2018
ebmwkzombv(pedtkhdoiw) = mfwsnueuzg peibfztjkv (unwlujosju, steqmzpvoy - fzbcycqvfi)
Phase 3
1,110
qyiihwgkwv(gsnizfxvvb) = dxypgiqspb zantgpahfc (hxnljaboht, qvzdtrpqww - bpxogxmdyg)
-
17 Aug 2018
(Reference)
qyiihwgkwv(gsnizfxvvb) = fyczsjqijn zantgpahfc (hxnljaboht, icurropqwq - ydwpxzvjen)
Phase 2
591
(Benzoyl Peroxide/Clindamycin + Tazarotene)
virumwokzz(eetfincvgl) = aatrgxlqld wbknuqbeck (muuhhhijkn, tjljbwbmhj - sukxqiyvki)
-
06 Mar 2017
(Benzoyl Peroxide/Clindamycin + Vehicle Cream)
virumwokzz(eetfincvgl) = ujoouarllf wbknuqbeck (muuhhhijkn, hncoyujdmy - clcmtaevkx)
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Regulation

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