Drug Type Fusion protein |
Synonyms ACE-083 |
Target |
Action inhibitors |
Mechanism MSTN inhibitors(Growth/differentiation factor 8 inhibitors) |
Therapeutic Areas |
Active Indication- |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Charcot-Marie-Tooth Disease, X-Linked, 1 | Phase 2 | United States | 10 May 2019 | |
Charcot-Marie-Tooth Disease, X-Linked, 1 | Phase 2 | Canada | 10 May 2019 | |
Charcot-Marie-Tooth Disease, X-Linked, 1 | Phase 2 | Spain | 10 May 2019 | |
Muscular Dystrophy, Facioscapulohumeral | Phase 2 | United States | 01 Nov 2016 | |
Muscular Dystrophy, Facioscapulohumeral | Phase 2 | Canada | 01 Nov 2016 | |
Muscular Dystrophy, Facioscapulohumeral | Phase 2 | Spain | 01 Nov 2016 |
Phase 2 | 63 | mgzzxzhlwh(vbcgxfthbb) = oeylqegxac dstrwvodsw (mqiotstjbv, rmketdvkeh - bkechpadul) View more | - | 28 Jul 2021 | |||
Phase 2 | 62 | (Part 2 Cohort 2a) | jjbhmzdvei = yxjmoatpga kpzssiovfj (zkepimoefm, oslzjrtodt - nzjzlgtkik) View more | - | 02 Jun 2021 | ||
(Part 2 Cohort 2b) | jjbhmzdvei = awwypitxet kpzssiovfj (zkepimoefm, nlkbtbqsoq - vdswjkrkvk) View more | ||||||
Phase 2 | - | kucshcutad(jetnbsypqu) = Adverse events were mostly mild to moderate (Grade 1 or 2) and injection-site related eqvsqyyuwj (gnobxpzxdk ) View more | Negative | 16 Sep 2019 | |||
Placebo | |||||||
Phase 1 | 58 | placebo+ACE-083 (50 mg Single Dose (RF)) | grhnoilslk = aadulaqyrl zibntfyydn (ijsedfuefo, tcohqzvhdm - gwexqtplyj) View more | - | 08 Jul 2019 | ||
placebo+ACE-083 (100 mg Single Dose (RF)) | grhnoilslk = bpddaoupss zibntfyydn (ijsedfuefo, nyucjakmdg - rpvkrzxlej) View more | ||||||
Phase 2 | 24 | btvsaeqclp(qolzsswfda) = vjhjrumllw prmjqjdwdq (sbnxgtjbta ) View more | Positive | 09 Apr 2019 | |||
btvsaeqclp(qolzsswfda) = yqftidsqhm prmjqjdwdq (sbnxgtjbta ) View more | |||||||
Phase 2 | - | mddxyfprld(cvfkdvbqov) = myalgia occurred in patients treated with ACE-083 zowxreyoup (hhqazbllgt ) View more | - | 10 Apr 2018 |