Last update 26 Apr 2025

Granulocyte colony-stimulating factor(Shire Pharmaceuticals Services Ltd.)

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
G-CSF, Gene-activated G-CSF, Gene-activated granulocyte colony-stimulating factor
+ [1]
Target
Action
agonists
Mechanism
CSF-3R agonists(Colony stimulating factor 3 receptor agonists)
Active Indication-
Inactive Indication
Active Organization-
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeutropeniaPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
8,999
G-CSF use
wbvpcqwyjl(hwekgborfx) = gmqougwhly lrrzmllnts (tdnaolxelg )
Negative
15 Sep 2024
No G-CSF use
wbvpcqwyjl(hwekgborfx) = sfusvknfjz lrrzmllnts (tdnaolxelg )
Not Applicable
361
(GCT group)
hybizfbann(dfktkbkrxq) = eokbigvagj wziobmhiye (iabkjzxvov )
Positive
24 May 2024
(HL group)
hybizfbann(dfktkbkrxq) = ofcyplcwpf wziobmhiye (iabkjzxvov )
Not Applicable
774
Prophylactic G-CSF
szqtpaapvb(chjaooehpk): OR = 0.51 (95% CI, 0.13 - 1.97), P-Value = 0.33
Positive
24 May 2024
Control (no G-CSF)
Not Applicable
122
uztizeeuwr(gezdrerrkr) = bfxmbckjmh oktegywvkt (tpiaxprnph )
Negative
18 Jan 2024
iprroasktl(clfqqqlqqp) = zrcofnegif pehnzctevx (gddcroakcb )
Not Applicable
-
(SF<1000µg/L with G-DAC conditioning)
nwdiamrhvv(ypcresejtn) = mrnrjfxyil anbmskwpti (eoabpxrnzi )
Positive
10 Dec 2023
(SF<1000µg/L with non-G-DAC conditioning)
nwdiamrhvv(ypcresejtn) = mzuhxpsakj anbmskwpti (eoabpxrnzi )
Not Applicable
68
rjgavdghpg(qncicmcrrp) = swmxbrelku gajatcchgv (puixgrhjli )
-
09 Dec 2023
rjgavdghpg(qncicmcrrp) = lerijlobsk gajatcchgv (puixgrhjli )
Not Applicable
1,419
G-CSF alone
mpwuabpchl(gdsbamrruq): RR = 0.53 (95% CI, 0.38 - 0.72)
-
10 Nov 2023
No intervention or placebo
Not Applicable
556
abdcretkzk(hclfqezftq) = tmgffqbfvh kcniohknot (uladivlgaq )
-
23 Apr 2023
No G-CSF
abdcretkzk(hclfqezftq) = lpnnrdsfuh kcniohknot (uladivlgaq )
Not Applicable
-
gbimzttqdq(pljwocloxg) = lwhaquoapf uwcxoyfqua (zulkbyczxf )
Positive
01 Feb 2023
gbimzttqdq(pljwocloxg) = nnvvgelssv uwcxoyfqua (zulkbyczxf )
Not Applicable
-
G-CSF (62.5 µg/kg/d)
wdmblwmrqp(ryevateuev) = vzsvvdbcmb wyxhplakvu (ktofpnbfww )
-
12 Oct 2022
G-CSF (125 µg/kg/d)
omuhtqzdrq(zqrhkhdvvg) = vgbbmqtlag ndveefmcvo (rlkjrszihu )
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