单次给药主要研究目的：考察中国健康受试者在空腹条件下，单次口服不同剂量水平的醋酸艾司利卡西平片的药代动力学（Pharmacokinetics, PK）特征和PK种族敏感性。多次给药主要研究目的：考察中国健康受试者在空腹条件下，多次口服同一剂量的醋酸艾司利卡西平片的药代动力学（Pharmacokinetics, PK）特征。

[Translation]

The main purpose of single-dose administration is to investigate the pharmacokinetic (PK) characteristics and PK ethnic sensitivity of eslicarbazepine acetate tablets at different dose levels in Chinese healthy subjects under fasting conditions. The main purpose of multiple-dose administration is to investigate the pharmacokinetic (PK) characteristics of eslicarbazepine acetate tablets at the same dose in Chinese healthy subjects under fasting conditions.

Start Date24 Sep 2024

Sponsor / Collaborator

Shanghai Shangyao Chinese-Western Pharmaceutical Co., Ltd

[+1]

CTR20220017

/ CompletedPhase 3

一项多中心、随机、双盲、安慰剂对照短期研究及为期一年的开放性、非对照安全扩展研究，评价醋酸艾司利卡西平片用于成人局灶起源癫痫伴有或不伴有局灶进展为双侧强直阵挛发作添加治疗的有效性和安全性以及长期疗效和安全性

[Translation] A multicenter, randomized, double-blind, placebo-controlled short-term study and a one-year open-label, non-controlled safety extension study to evaluate the efficacy and safety of eslicarbazepine acetate tablets as add-on treatment for adults with focal epilepsy with or without focal progression to bilateral tonic-clonic seizures, as well as long-term efficacy and safety

评价醋酸艾司利卡西平片用于成人局灶起源癫痫伴有或不伴有局灶进展为双侧强直阵挛发作添加治疗的疗效。

[Translation]

To evaluate the efficacy of eslicarbazepine acetate tablets as add-on treatment for adults with epilepsy of focal origin with or without focal progression to bilateral tonic-clonic seizures.

Start Date28 Jul 2022

Sponsor / Collaborator

Shanghai ZhongXi Pharmaceutical Co. Ltd.

[+1]

CTR20201102

/ CompletedNot Applicable

醋酸艾司利卡西平片在健康受试者中随机、开放、两周期、双交叉空腹和餐后状态下的生物等效性试验

[Translation] A randomized, open-label, two-period, double-crossover bioequivalence study of eslicarbazepine acetate tablets in healthy subjects under fasting and fed conditions

研究空腹或餐后状态下，单次口服醋酸艾司利卡西平片受试制剂(规格：400mg，生产商：扬子江药业集团有限公司，提供商：扬子江药业集团北京海燕药业有限公司）与参比制剂（Aptiom®，规格：400mg，持证商：Sunovion Pharmaceuticals Inc. ）在健康受试者体内的药代动力学行为，评价两种制剂的生物等效性。观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

To study the pharmacokinetic behavior of the test preparation of eslicarbazepine acetate tablets (specification: 400 mg, manufacturer: Yangtze River Pharmaceutical Group Co., Ltd., provider: Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd.) and the reference preparation (Aptiom®, specification: 400 mg, licensee: Sunovion Pharmaceuticals Inc.) in healthy subjects after a single oral administration in the fasting or postprandial state, and to evaluate the bioequivalence of the two preparations. To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date08 Jun 2020

Sponsor / Collaborator

Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd.

100 Clinical Results associated with Eslicarbazepine Acetate

100 Translational Medicine associated with Eslicarbazepine Acetate

100 Patents (Medical) associated with Eslicarbazepine Acetate

604

Literatures (Medical) associated with Eslicarbazepine Acetate

01 Jun 2026·NEUROBIOLOGY OF DISEASE

Targeting diaschisis to alleviate memory deficits after experimental stroke

Article

Author: Reichelt, Kristian ; Adenauer, Lea ; Opitz, Thoralf ; Contini, Ginevra ; Pires, Nuno ; Beck, Heinz

Stroke is one of the most common central nervous system causes of morbidity and mortality. Cognitive impairment is a common and long-term consequence of stroke, with considerable impact on the quality of life. However, despite the high prevalence and importance of post-stroke cognitive dysfunction, there are currently no effective treatments directly aimed at improving or preventing cognitive dysfunction. Here, we show that small unilateral photothrombotic stroke in the murine motor cortex causes widespread bilateral increases in excitability assessed via c-Fos labelling. Increased activity in the hippocampal and prefrontal cortical regions was associated with pronounced deficits in object memory, but not working memory. Application of the anti-seizure drug eslicarbazepine acetate normalized the hyperexcitability and reversed post-stroke memory deficits. These data suggest that diaschisis, denoting remote effects of focal lesions, is associated even with small stroke lesions. Moreover, this study suggests that anti-seizure drugs can reduce abnormal excitability and improve cognition after experimental stroke. This finding may have implications for treatment of cognitive deficits in post-stroke patients, but this will require further confirmation by clinical studies.

01 Jun 2026·CURRENT OPINION IN NEUROLOGY

Medical management of refractory trigeminal neuralgia

Review

Author: Stern, Jennifer I ; Robertson, Carrie E ; Chiang, Chia-Chun

Purpose of review:

First- and second-line medical and surgical therapies for trigeminal neuralgia (TN) may have limited efficacy or tolerability in some individuals. In addition, even when these therapies are initially successful, efficacy frequently wanes over time. This narrative review presents medication options for intractable trigeminal neuralgia with a focus on new and upcoming therapies.

Recent findings:

Lacosamide, eslicarbazepine, and botulinum toxin are increasingly used for intractable TN, with recent studies demonstrating efficacy. Basimglurant and vixotrigine (BIIB074) are investigational agents currently or recently studied for treatment of TN. Intravenous (i.v.) sodium channel blockers, i.v. magnesium, multiple formulations of lidocaine, and sumatriptan can be used for acute treatment of intractable TN.

Summary:

Multiple medical therapies exist for treatment of intractable TN, with newer options demonstrating efficacy in recent studies. Investigational agents are currently being studied as potential future options for management of intractable TN.

01 Mar 2026·LANCET NEUROLOGY

Safety and efficacy of eslicarbazepine acetate for seizure prevention in patients with stroke at high risk of developing post-stroke epilepsy: a proof-of-concept, phase 2a, randomised, double-blind, placebo-controlled antiepileptogenesis trial

Article

Author: Trinka, Eugen ; Fonseca, Miguel M ; Gigli, Gian Luigi ; Gama, Helena ; Knake, Susanne ; Mah, Yee-Haur ; Castilla-Fernández, Guillermo ; Zelano, Johan ; Ramos, Daniel ; Moreira, Joana ; Koepp, Matthias J ; Galovic, Marian ; Holenz, Joerg ; Kippert, Angelika ; Löscher, Wolfgang ; Pires, Nuno ; Simister, Robert ; Serratosa, José M ; Brigo, Francesco ; Di Foggia, Valentina ; Magalhães, Luis M ; Bentes, Carla

BACKGROUND:

Eslicarbazepine acetate is an antiseizure medication that has shown potential antiepileptogenic effects in preclinical models of epilepsy. We aimed to investigate whether eslicarbazepine acetate could prevent or reduce the incidence of unprovoked seizures after acute ischaemic stroke or acute intracerebral haemorrhage.

METHODS:

Study BIA-2093-213 was an exploratory, proof-of-concept, phase 2a, double-blind, randomised, placebo-controlled trial conducted in adults (aged ≥18 years) after an acute ischaemic stroke or acute intracerebral haemorrhage, who were considered at high risk of developing unprovoked seizures based on a severity of stroke, large artery atherosclerosis, early seizure, cortical involvement, and territory of the middle cerebral artery (SeLECT) score of 5 or greater or a cortical involvement of intracerebral haemorrhage, age, volume, and early seizure after intracerebral haemorrhage (CAVE) score of 2 or greater. Patients were recruited from 19 university hospitals across Austria, Germany, Italy, Israel, Portugal, Spain, Sweden, and the UK, and eligible for inclusion if randomisation was planned within 96 h since the known time of stroke, or last time seen well (prolonged to 120 h to allow detection of acute seizures within 5 days post-stroke following a protocol modification implemented early in recruitment). Participants were randomly assigned (1:1) to receive eslicarbazepine acetate 800 mg/day or placebo, administered orally, for 30 days and followed up for 17 additional months. All patients who received one dose of study drug were included in safety and efficacy analyses. The primary endpoint was the proportion of patients who had a first unprovoked seizure, died, or discontinued (for any reason) within the first 6 months after randomisation. This trial is registered on the EudraCT database (EudraCT 2018-002747-29).

FINDINGS:

Between May 29, 2019, and Feb 28, 2022, 129 patients were screened and 125 were randomly assigned (62 to eslicarbazepine acetate and 63 to placebo). The between-group difference for the primary endpoint (17 [28%] of 61 with eslicarbazepine acetate vs 23 [37%] of 62 with placebo) was not significant (odds ratio 0·66 [95% CI 0·31-1·40]; p=0·37). Treatment-emergent adverse events were reported with similar frequency in both eslicarbazepine acetate and placebo groups (50 [82%] of 61 vs 51 [82%] of 62). The most common treatment-emergent adverse events were hyponatraemia (five [8%] of 61 in the eslicarbazepine acetate group vs one [2%] of 62 in the placebo group), dizziness (three [5%] vs none). Serious treatment-emergent adverse events were reported in 12 (20%) patients in the eslicarbazepine acetate group and 13 (21%) in the placebo group. Three serious related treatment-emergent adverse events occurred in the eslicarbazepine acetate group (none in the placebo group): nodal arrhythmia, hepatic failure, and hyponatraemia (one patient each). Five patients died after randomisation (all in the eslicarbazepine acetate group), but deaths were deemed unrelated or unlikely to be related to the study drug.

INTERPRETATION:

The proportion of patients who had a first unprovoked seizure, died, or discontinued at 6 months did not differ significantly between the eslicarbazepine acetate and placebo groups. However, the trial was underpowered owing to slow recruitment and the COVID-19 pandemic, producing wide confidence intervals. The findings indicate that antiepileptogenesis studies are feasible, and guide the design of adequately powered trials with clinically meaningful endpoints.

FUNDING:

BIAL.

News (Medical) associated with Eslicarbazepine Acetate

22 Oct 2025

·www.drugs.com

New Study Offers Hope for People With Drug-Resistant Epilepsy

WEDNESDAY, Oct. 22, 2025 — For the estimated one-third of people with focal epilepsy who don’t respond well to initial medications, new research offers significant reason for optimism. A study suggests that even those considered "treatment-resistant" may eventually see a substantial reduction in their seizures over time. Focal epilepsy , the most common form of the neurological disorder, occurs when nerve cells in one area of the brain fire off an excessive burst of electrical signals. These focal seizures can manifest as unusual behaviors, abnormal emotions or strange sensations. The new study, part of the international Human Epilepsy Project , tracked nearly 150 adults who were deemed treatment-resistant. In other words, they still had seizures despite having tried at least four different anti-seizure medications. Some participants also had implantable devices. The researchers monitored participants for up to three years. The results, published Oct. 20 in JAMA Neurology , showed a promising outcome: 68% of participants had a reduction in seizure frequency during the second half of the study compared to the first half. This finding directly contradicts the long-held assumption that the prospect for relief is remote when patients fail a handful of medications. “Our findings challenge the assumption that once a patient with focal epilepsy has failed a certain number of anti-seizure drugs, their chances of finding relief are small and not worth the effort,” said lead author Dr. Ojas Potnis, a neurology resident at the NYU Grossman School of Medicine in New York City. While medications rarely halted seizures completely, they did appear to lengthen the intervals between episodes for some patients, the study found. Almost 13% of volunteers went at least three months without a seizure. Almost 13% of volunteers went at least three months without a seizure. Nearly 8% were seizure-free for at least six months. Nearly 8% were seizure-free for at least six months. And 3% of patients achieved a full year or more without a seizure. And 3% of patients achieved a full year or more without a seizure. Potnis noted that these percentages, while appearing small, are higher than those found in earlier studies, which followed patients for just three months. This suggests that achieving seizure reduction is often a long game. The data also indicated that the total number of medications a patient had failed previously had no bearing on their future likelihood of improvement. The study noted that the four most common anti-seizure medications used by participants who experienced seizure reduction were all approved within the past 15 years. They are cenobamate , clobazam , eslicarbazepine and epidiolex . The researchers also found that whether or not patients had an implantable device had no effect on seizure trajectory. “These results offer hope that focal epilepsy will get better over time for most people,” said co-senior author Dr. Jacqueline French , a neurologist and professor at the NYU Grossman School of Medicine. “Health care providers should keep searching for the best treatment regimen for their patients no matter how many therapies they may need to try,” she added in a news release. The researchers said it remains unclear whether this gradual reduction in seizures is a result of therapeutic management — as more than half of those who improved started a new drug during the study — or the natural progression of disease over time. The study was funded by UCB, Neurelis and SK Life Science. Sources NYU Langone Health, news release, Oct. 20, 2025 JAMA Neurology, Oct. 20, 2025

Clinical Result

10 Jul 2023

·www.biospace.com

Sumitomo Pharma America Launches as New Combined Organization with Expanded Scale, Resources & Capabilities

CAMBRIDGE, Mass., July 10, 2023 /PRNewswire/ -- Sumitomo Pharma America, Inc. (SMPA), as previously announced on April 3, 2023, is pleased to share it has successfully launched its operations in the U.S. and related markets. The newly combined company is focused on addressing unmet patient needs in critical disease areas across psychiatry & neurology, oncology, urology, women's health, rare disease, and cell & gene therapies. SMPA's diverse portfolio includes six marketed products and a robust pipeline of early- to late-stage assets, with topline data for two of its Phase 3 candidates in the fields of psychiatry and urology expected this quarter. The company will apply its proprietary advanced analytics and computational technology platforms to support and accelerate its diverse pipeline and commercial programs as well as needed innovations in priority areas of discovery, science, research and development. SMPA's President and Chief Executive Officer, Myrtle Potter, Chief Executive Officer of Biopharma, Adele Gulfo, and Chief Medical Officer, Armin Szegedi, were appointed as Executive Officers of Sumitomo Pharma Co., Ltd. effective July 1, 2023. Innovation Growth Engine "We are pleased to have successfully completed the combination of Sumitomo Pharma's U.S. subsidiaries to form SMPA," said Hiroshi Nomura, Representative Director, President and Chief Executive Officer of Sumitomo Pharma. "As a Sumitomo Pharma Group growth engine, SMPA will focus on maximizing the value of the three key products early, namely, ORGOVYX®, MYFEMBREE®, and GEMTESA®. SMPA will propel scientific and therapeutic innovations to meaningfully impact the evolving health needs of patients in North America and promote development to meet the needs of patients worldwide while also delivering long-term value to society as a stronger, more profitable enterprise." "SMPA comprises some of the brightest talent in drug development, business, science, and technology, operating as one global team to push beyond industry norms and reimagine what's possible," said Myrtle Potter, President and Chief Executive Officer, Sumitomo Pharma America. "Our goal is to realize new treatments with greater benefit to patients while maximizing the potential of our key marketed and development assets to better support areas of critical need and provide potential treatment options where solutions are lacking or do not exist." Commercial Biopharma Business Adele Gulfo, Chief Executive Officer of Biopharma Commercial of Sumitomo Pharma America, said, "SMPA is poised to help solve health challenges in critical disease areas through the exceptional talents and dedication of our highly experienced cross-functional team. SMPA's broad product portfolio, including key brands, ORGOVYX®, MYFEMBREE® and GEMTESA®, will drive the growth of our business and fuel future potential investments. We are deeply committed to the patients we serve in oncology, women's health, urology, rare disease, psychiatry, and neurology, as well as our additional products APTIOM®, RETHYMIC®, and LATUDA®, which healthcare providers and patients continue to rely on." R&D & Pipeline Armin Szegedi, Chief Medical Officer of Sumitomo Pharma America, said, "SMPA has a robust and balanced pipeline, with more than 30 assets and dozens of clinical trials currently underway, to address areas of significant need in psychiatry, neurology, oncology, urology, and regenerative medicine. I am excited about the opportunities we have at SMPA to develop innovative treatments across multiple therapeutic indications, including our lead pipeline candidate, ulotaront, which is being studied in individuals living with schizophrenia, generalized anxiety disorder and the adjunctive treatment of major depressive disorder." Jatin Shah, Chief Oncology Development Officer of Sumitomo Pharma America, added, "SMPA is uniquely positioned with a strong internal discovery and translational research engine committed to the identification and development of innovative, best-in-class, oncology therapies. We are also looking forward to quickly advancing our oncology programs including, TP-3654, an investigational selective oral PIM1 kinase inhibitor, being studied for patients with myelofibrosis (MF) and DSP-5336, an investigational small molecule inhibitor against the binding of menin and mixed-lineage leukemia (MLL) protein, being evaluated for the treatment of acute myeloid leukemia (AML)." SMPA's leadership team comprises industry-leading experts with deep life sciences expertise across the business and drug development spectrum, as well as quality & manufacturing, commercialization, and data & analytics. We invite you to learn about SMPA's full leadership team and capabilities on our new website: . About Sumitomo Pharma America, Inc. Sumitomo Pharma America (SMPA) is focused on delivering therapeutic and scientific breakthroughs in areas of critical patient need spanning psychiatry & neurology, oncology, urology, women's health, rare disease, and cell & gene therapies. The company's diverse portfolio includes several marketed products and a robust pipeline of early- to late-stage assets. SMPA leverages proprietary in-house advanced analytics and computational technology platforms to accelerate discovery, research, and help bring novel therapies to patients sooner. SMPA is a Sumitomo Pharma Co., Ltd., company. For more information on SMPA, visit our website or follow us on LinkedIn. About Sumitomo Pharma Co., Ltd. Sumitomo Pharma is among the top-ten listed pharmaceutical companies in Japan, operating globally in major pharmaceutical markets, including Japan, the U.S., China, and other Asian countries with more than 6,000 employees worldwide. Sumitomo Pharma defines its Mission as "To broadly contribute to society through value creation based on innovative research and development activities for the betterment of healthcare and fuller lives of people worldwide." Additional information about Sumitomo Pharma is available through its corporate website at . Forward-Looking Statements This press release contains forward-looking statements that may be deemed to be "forward-looking statements" within the meaning of applicable securities laws and Sumitomo Pharma America, Inc. may make related oral, forward-looking statements on or following the date hereof. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intend," "guidance," "future" or similar expressions are forward-looking statements. Forward-looking statements, by their nature, are subject to a variety of inherent risks and uncertainties that could cause actual results to differ materially from the results projected and reported results should not be considered as an indication of future performance. Many of these risks and uncertainties cannot be controlled by Sumitomo Pharma America, Inc. and you should not place undue reliance on any forward-looking statements. These forward-looking statements are based on information available to Sumitomo Pharma America, Inc. as of the date of this communication and speak only as of the date of this communication. Sumitomo Pharma America, Inc. does not assume any obligation to publicly update any forward-looking statements, except as may be required by law. No information contained on any website referenced in this press release is incorporated by reference herein. Sumitomo Pharma America, Inc. is a registered trademark of Sumitomo Pharma Co., Ltd. Sumitomo Pharma America, Inc. is a U.S. subsidiary of Sumitomo Pharma Co., Ltd. © 2023 Sumitomo Pharma America, Inc. All rights reserved. SMPA IR / Media Contact: Maya Frutiger VP, Head of Corporate Communications Sumitomo Pharma America, Inc. CorpComms@us.sumitomo-pharma.com View original content to download multimedia: SOURCE Sumitomo Pharma America, Inc.

Executive ChangePhase 3

20 Feb 2009

·www.pharmatimes.com

EMEA calls for Raptiva suspension, issues latest recommendations

On a busy day for the regulator, the European Medicines Agency has recommended that marketing authorisation be suspended for Merck KGaA/Genentech's psoriasis drug Raptiva over possible links between the drug and a rare but deadly brain infection. The EMEA’s Committee for Medicinal Products for Human Use (CHMP) said the benefits of Raptiva (efalizumab) no longer outweigh its risks, because of safety concerns, notably the occurrence of progressive multifocal leukoencephalopathy (PML) in patients taking the medicine. The CHMP noted three confirmed cases of PML in patients who had taken Raptiva for more than three years, two of resulted in the patient’s death, and the agency has received an additional report of a suspected case of PML, “which could not be confirmed”. Nevertheless, following a review, the CHMP has concluded that “Raptiva’s benefits are modest”. In addition to PML, Raptiva is associated with other serious side effects, including Guillain-Barre and Miller-Fisher syndromes, encephalitis, encephalopathy, meningitis, sepsis and opportunistic infections,” the EMEA noted. It added that “there is not enough evidence to identify a group of patients in which the benefits of Raptiva outweigh its risks”. The EMEA’s call for suspension came as its counterpart in the USA, the Food and Drug Administration, issued a public health advisory about the three confirmed reports of PML and the possible fourth case. The FDA stated that it will “take appropriate steps to ensure that the risks of Raptiva do not outweigh its benefits”. Merck, which markets Raptiva in Europe, said it would work with health authorities across the continent "to undertake all necessary measures to comply with the EMEA recommendations." Earlier this week, the Darmstadt-based group noted that it had written off 195 million euros due to “sharply lower sales expectations” for the drug. Staying with the EMEA, the agency has issued the latest list of positive opinions from the CHMP. The drugs recommended for approval include Wyeth’s Conbriza (bazedoxifene) for postmenopausal osteoporosis, Bial’s anti-epileptic Zebinix (eslicarbazepine; see story on today’s elert) and Fresenius’ Removab (catumaxomab) for the removal of cancerous fluid from the abdomen. The CHMP is also recommending approval for Nycomed’s over-the-counter versions of its own heartburn drug Pantozol (pantoprazole) and Teva’s generic version of Novartis’ anti-dementia drug Exelon (rivastigmine). However, it adopted a negative opinion for Biferonex (interferon-beta-1a), from Switzerland’s BioPartners, for multiple sclerosis. BioPartners is appealing the decsion, claiming that Biferonex demonstrated safety and efficacy profiles comparable to established interferon beta-1a products already on the market".

100 Deals associated with Eslicarbazepine Acetate

External Link

KEGG	Wiki	ATC	Drug Bank
D09612	Eslicarbazepine Acetate	N03AF04	DB09119

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Epilepsy	South Korea	Whan In Pharmaceutical Co., Ltd.	10 Nov 2020
Epilepsies, Partial	European Union	BIAL-Portela & Cia SA	21 Apr 2009
Epilepsies, Partial	Iceland	BIAL-Portela & Cia SA	21 Apr 2009
Epilepsies, Partial	Liechtenstein	BIAL-Portela & Cia SA	21 Apr 2009
Epilepsies, Partial	Norway	BIAL-Portela & Cia SA	21 Apr 2009

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetic peripheral neuropathic pain	Phase 3	Portugal	BIAL-Portela & Cia SA	01 Nov 2010
Neuralgia, Postherpetic	Phase 3	Germany	BIAL-Portela & Cia SA	01 Sep 2010
Epilepsy, Complex Partial	Phase 3	United States	BIAL-Portela & Cia SA	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	United States	Sumitomo Pharma America, Inc.	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Argentina	BIAL-Portela & Cia SA	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Argentina	Sumitomo Pharma America, Inc.	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Belgium	Sumitomo Pharma America, Inc.	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Belgium	BIAL-Portela & Cia SA	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Brazil	BIAL-Portela & Cia SA	02 Dec 2008
Epilepsy, Complex Partial	Phase 3	Brazil	Sumitomo Pharma America, Inc.	02 Dec 2008

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT06597084 (CTgov)	Phase 2	Stroke \| Seizures \| Epilepsy ... View more	129	ESL 800 mg (Group A)	updlrkcmzp = ykjjdyzthd fjmuqgtulf (aqwuwwrtvo, phfbdvqngt - gzwgrbzpet) View more	-	02 May 2025
				Placebo (Group B)	updlrkcmzp = vxfjyaqolc fjmuqgtulf (aqwuwwrtvo, xizbattvgk - uxhnrilchr) View more
IEC2023	Not Applicable	-	849	Eslicarbazepine Acetate	nodlzaypoq(mubepiqcjg) = 43 reports wmvgbjutee (kjmxhipnnz ) View more	-	04 Sep 2023
AAN2023	Phase 3	Seizures	1,447	Eslicarbazepine Acetate 800mg	autyempuwz(uvtgippxzt) = Incidence of AEs and AEs leading to discontinuation increased with ESL dose fsbliecmus (jawjprfjul ) View more	Positive	25 Apr 2023
				Eslicarbazepine Acetate 1200mg
NCT02484001 (NCT01162460/NCT02484001; EudraCT 2009-011135-13/2015-001243-36, Pubmed \| Ther Adv Neurol Disord)	Phase 3	Seizures plasma lipid levels \| total cholesterol \| low-density lipoprotein (LDL) cholesterol	184	Eslicarbazepine acetate (ESL)	ipmthtmkdq(srscteafrb) = pplxlekfkq gttqwphxnn (ditanwxkkq ) View more	Positive	01 Jan 2023
				Controlled-release carbamazepine (CBZ-CR)	ipmthtmkdq(srscteafrb) = jxegzqsnkf gttqwphxnn (ditanwxkkq ) View more
BIA-2093-208 \| BIA-2093-305 (EAN2022)	Phase 2/3	Seizures	-	Eslicarbazepine acetate	itzhfslvur(ydfbahwjpi) = vbzletzllu kurtcycyrk (tpbzugibqt ) View more	Positive	24 Jun 2022
				Placebo	itzhfslvur(ydfbahwjpi) = phkmvxdoiu kurtcycyrk (tpbzugibqt ) View more
BIA-2093-304 (EAN2021)	Not Applicable	-	496	Eslicarbazepine acetate 800mg/day	naoxwwjfju(odmedzyqil) = 7.5% in Part II and not reported in Part III nnhhfnwdjm (eobwcwsbvf ) View more	Positive	18 Jun 2021
				Eslicarbazepine acetate 400-1600mg/day
NCT00957047 \| NCT00957684 \| NCT00988429 (Pubmed \| Epilepsy Res)	Phase 3	Epilepsies, Partial \| Seizures	-	eslicarbazepine acetate (Older adults (≥60 years))	xruyrunlpo(mrxrmevlyx) = mjnzsqsivm tuvdsigzky (utfcewykqv ) View more	-	01 Jan 2021
				eslicarbazepine acetate (Younger adults (18-59 years))	xruyrunlpo(mrxrmevlyx) = snyeypyqla tuvdsigzky (utfcewykqv ) View more
NCT02484001 (Pubmed) Manual	Phase 3	Epilepsies, Partial	184	eslicarbazepine acetate (ESL/ESL)	nnsjsxygnv(lqlgxbkfkl) = fpznistkbv gehxmashaq (wloheephti, 0.0292 - 0.1366) View more	Positive	01 Oct 2020
				controlled-release carbamazepine+eslicarbazepine acetate (CBZ-CR/ESL)	nnsjsxygnv(lqlgxbkfkl) = cubxcerisx gehxmashaq (wloheephti, 0.0180 - 0.1210) View more
NCT03116828 (1585, CTgov)	Phase 4	Epilepsies, Partial	102	eslicarbazepine acetate (Eslicarbazepine Acetate (Arm 1))	glroyyllfm = fsqinlkjfs wscsdrbdfm (wmegnjygkb, ogxfywuotn - gssohryxab)	-	16 Jun 2020
				eslicarbazepine acetate (Eslicarbazepine Acetate (Arm 2))	glroyyllfm = aohhvhtbqi wscsdrbdfm (wmegnjygkb, szmpzkjmrq - uunoyoqmph)
AAN2020	Phase 3	Seizures	1,447	Placebo	zwnbrldjni(cmmatjhzgp) = kdawxtghpg jeddmmvwby (feazhrpyyd )	Positive	14 Apr 2020
				Eslicarbazepine Acetate 800 mg	zwnbrldjni(cmmatjhzgp) = upddpuxuup jeddmmvwby (feazhrpyyd )

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Regulation

Understand key drug designations in just a few clicks with Synapse.

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Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis