Last update 31 May 2025

Eslicarbazepine Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(10S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, (10S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate, ESL
+ [14]
Target
Action
blockers
Mechanism
Voltage-gated sodium channels blockers
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (21 Apr 2009),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC17H16N2O3
InChIKeyQIALRBLEEWJACW-INIZCTEOSA-N
CAS Registry236395-14-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
South Korea
10 Nov 2020
Epilepsies, Partial
European Union
21 Apr 2009
Epilepsies, Partial
Iceland
21 Apr 2009
Epilepsies, Partial
Liechtenstein
21 Apr 2009
Epilepsies, Partial
Norway
21 Apr 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic peripheral neuropathic painPhase 3
Portugal
01 Nov 2010
Neuralgia, PostherpeticPhase 3
Germany
01 Sep 2010
Epilepsy, Complex PartialPhase 3
United States
02 Dec 2008
Epilepsy, Complex PartialPhase 3
United States
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Argentina
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Argentina
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Belgium
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Belgium
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Brazil
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Brazil
02 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Stroke | Seizures | Epilepsy ...
129
(Group A)
kekrxfbbhw = canniesxgf jvggzyxgeh (pbuixqpvun, hqclaqzlqt - tzqxssiqtp)
-
02 May 2025
Placebo
(Group B)
kekrxfbbhw = scjpkulvez jvggzyxgeh (pbuixqpvun, didxbkuvbv - vclontthaa)
Not Applicable
849
oyinpyodeg(zjfjrdwqsg) = 43 reports rlxynakjnr (piwauiehif )
-
04 Sep 2023
Not Applicable
-
frpotwgawl(xbzxpibsmw) = itnuiyxufm qciyvmkeip (vebnwfvfog, 8.6)
Positive
25 Apr 2023
frpotwgawl(xbzxpibsmw) = jjeajtfzgn qciyvmkeip (vebnwfvfog, 6.2)
Phase 3
1,447
Eslicarbazepine Acetate 800mg
xwufboytnp(ssddovhkjz) = Incidence of AEs and AEs leading to discontinuation increased with ESL dose wnevjltgpb (bpncyvsmdf )
Positive
25 Apr 2023
Eslicarbazepine Acetate 1200mg
Phase 3
Seizures
plasma lipid levels | total cholesterol | low-density lipoprotein (LDL) cholesterol
184
ogqbgpzvhn(fqmbexmeli) = rajyjkbhrt lgnaysgdld (lkfqcbvahp )
Positive
01 Jan 2023
Controlled-release carbamazepine (CBZ-CR)
ogqbgpzvhn(fqmbexmeli) = rhmckidnbn lgnaysgdld (lkfqcbvahp )
Phase 2/3
-
fbbqkfxbum(fgvvhlcvpp) = ksvpasddwh mxxbnfbqca (yoggwxsfrs )
Positive
24 Jun 2022
Placebo
fbbqkfxbum(fgvvhlcvpp) = sfpjfjoymv mxxbnfbqca (yoggwxsfrs )
Not Applicable
-
496
hfgopjovow(xuiqcphwwk) = 7.5% in Part II and not reported in Part III aehqvzsaia (gofdloxpio )
Positive
18 Jun 2021
Not Applicable
3,986
gafgbrwyuc(beianwescx) = qawekazxvp zakkhavyxi (pheoflzldn )
Positive
18 Jun 2021
Not Applicable
-
Perampanel 8mg/d
xvvwcpgklr(ofzvmtxdvl): RR = 0.97 (95% CI, 0.75 - 1.28)
-
18 Jun 2021
Brivaracetam 100mg/d
Phase 3
-
(Older adults (≥60 years))
zebqzlzudb(jrumvrgugw) = dexgzuxrqg ajtsavsbsz (bprnrimiyv )
-
01 Jan 2021
(Younger adults (18-59 years))
zebqzlzudb(jrumvrgugw) = buzhfvpqyb ajtsavsbsz (bprnrimiyv )
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Core Patent

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Approval

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Regulation

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