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Clinical Trials associated with TQ-B3525[14C] TQ-B3525在中国成年男性健康受试者体内的吸收、代谢和排泄临床试验-[14C] TQ-B3525人体物质平衡及生物转化研究
[Translation] [14C] TQ-B3525 Absorption, Metabolism and Excretion Clinical Trial in Chinese Adult Male Healthy Subjects - [14C] TQ-B3525 Human Material Balance and Biotransformation Study
评价盐酸安罗替尼胶囊在轻度和中度肝功能不全受试者与健康受试者体内的药代动力学差异,为制定肝功能不全患者的临床用药方案提供依据。
[Translation] To evaluate the pharmacokinetic differences of anlotinib hydrochloride capsules in subjects with mild and moderate hepatic impairment and healthy subjects, and to provide a basis for formulating clinical medication regimens for patients with hepatic impairment.
Clinical Trial on Absorption, Metabolism and Excretion of [14C] TQ-B3525 in Chinese Adult Male Healthy Subjects - Research on Material Balance and Biotransformation of [14C] TQ-B3525
A clinical study to investigate the absorption, metabolism and excretion of [14C] TQ-B3525 in Chinese adult male healthy subjects, aiming to quantitatively analyze the total radioactivity in the excreta of male healthy subjects after oral administration of [14C] TQ-B3525, obtain the data of human radioactive excretion rate and main drainage routes, investigate the distribution in whole blood and plasma, the distribution in plasma and the pharmacokinetics of total radioactivity in plasma, and identify the main metabolites, To determine the main biotransformation pathway and obtain the pharmacokinetic parameters of TQ-B3525 and its metabolites in plasma.
A Single-arm, Open-label, Multi-cohort, Multi-center Clinical Study on the Safety and Efficacy of TQ-B3525 Tablets Combined With Osimertinib in Subjects With Advanced Non-small Cell Lung Cancer
TQ-B3525 tablet is a new α/δ dual inhibitor phosphatidylinositol 3-kinase inhibitor developed by Chia Tai Tianqing pharmaceutical Group Co., Ltd. It can overcome the drug resistance problem caused by the up-regulation of phosphatidylinositol 3-kinase α subunit activity caused by the single inhibition of phosphatidylinositol 3-kinase δ subunit. This study is a single-arm, open-label, multi-cohort, multi-center clinical study of the safety and efficacy of TQ-B3525 tablets combined with osimertinib in subjects with advanced non-small cell lung cancer, aiming to evaluate TQ-B3525 tablets combined with osimertinib, the safety, tolerability, and efficacy of the treatment of patients with advanced non-small cell lung cancer who have failed epidermal growth factor receptor inhibitor therapy, while exploring the efficacy, resistance mechanism, and safety in the dose escalation phase biomarkers.
100 Clinical Results associated with TQ-B3525
100 Translational Medicine associated with TQ-B3525
100 Patents (Medical) associated with TQ-B3525
100 Deals associated with TQ-B3525