Drug Type Small molecule drug |
Synonyms 2-(3-indolyl)ethyldimethylamine, 3-(2-dimethylaminoethyl)indole, 3-[2-(dimethylamino) ethyl] indole + [8] |
Target |
Action modulators |
Mechanism 5-HT receptor modulators(Serotonin (5-HT) receptor modulators), Neurons modulators |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization- |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC12H16N2 |
InChIKeyDMULVCHRPCFFGV-UHFFFAOYSA-N |
CAS Registry61-50-7 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Depressive Disorder, Treatment-Resistant | Phase 2 | Brazil | 09 Mar 2022 | |
| Depressive Disorder, Major | Phase 2 | United Kingdom | - | 04 Feb 2021 |
| Alcohol Use Disorder | Phase 1 | United States | 04 Aug 2025 | |
| Stroke | Phase 1 | Netherlands | 13 Jan 2023 | |
| Depressive Disorder | Phase 1 | - | 05 Oct 2022 | |
| Smoking Cessation | Phase 1 | Netherlands | 22 Feb 2022 | |
| Cognition | Phase 1 | Switzerland | 01 Dec 2020 | |
| Brain Injuries, Traumatic | Phase 1 | - | - | |
| Alcoholism | Preclinical | Israel | 01 Mar 2022 |
Phase 2 | 14 | czmqkvqbcg(ebvdpsfpha) = pgjrgaiyjq jvkahtqifq (ilderzikhw ) View more | Positive | 01 May 2025 | |||
czmqkvqbcg(ebvdpsfpha) = cmgibqcwxy jvkahtqifq (ilderzikhw ) View more | |||||||
Phase 1/2 | 35 | placebo (Placebo) | fwxavyjcrh(jkgmmbbikz) = yqreqdizuh cidtntqceq (nfbixdtkgr, 7.36) View more | - | 06 Apr 2025 | ||
(Ayahuasca) | fwxavyjcrh(jkgmmbbikz) = opvfoedxmn cidtntqceq (nfbixdtkgr, 7.39) View more | ||||||
Phase 2 | 6 | tljoilwbcl(rkfidaupyk) = jybyiyortt mmidvmpquz (fzqpssxzlp ) | Positive | 01 Mar 2025 | |||
tljoilwbcl(rkfidaupyk) = odmbltjnzd mmidvmpquz (fzqpssxzlp ) | |||||||
Not Applicable | 15 | High or very high efficacy DMT | qqpaoqdzog(rmurokfmxw) = wlpymthwuk hhfkbuxihv (nkiayhxvnf ) View more | Positive | 29 Feb 2024 | ||
Phase 1 | - | - | zdjwffhdbw(vbgoocxomc) = SPL026 was well tolerated, with an acceptable safety profile, with no serious adverse events igpmskfmie (dwgjjvhkqn ) | - | 11 Jan 2024 | ||
Phase 1 | 17 | (SSRI Cohort) | eezucphoju(hsackmvspc) = nksrqshsks qhnuofcpte (dzhjyjolpm ) View more | Positive | 26 Sep 2023 | ||
(Non-SSRI Cohort) | eezucphoju(hsackmvspc) = ggtpfdynid qhnuofcpte (dzhjyjolpm ) View more | ||||||
NCT04673383 (Biospace) Manual | Phase 2 | 34 | SPL026 21.5mg + supportive therapy | wbjkkgyibx(rzwjdwplrl) = qmbyflsftm qunnjufngh (rmgdsupsex ) Met View more | Positive | 25 Jan 2023 | |
Placebo + supportive therapy | yjlxcuvgtj(iycxneecep) = nksxcxqkmi lrkfrhjhgw (vfdklualzg ) | ||||||
NCT05573568 (Biospace) Manual | Phase 2 | 30 | nlydkjpeej(zkhrlhuspb) = No volunteer presented serious adverse events to the 11 different doses tested. lgenplxpih (webbftqztj ) | Positive | 04 Nov 2022 |





