Last update 25 Jan 2025

INV-1120

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
EP4
Mechanism
EP4 antagonists(Prostanoid EP4 receptor antagonists), Immunomodulators
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmNeoplasm MetastasisSolid tumor
Inactive Indication
Metastatic Solid Tumor
Originator Organization
Ionova Life Science Co., Ltd.Ionova Life Science Co., Ltd.Startup
Active Organization
Shenzhen Ionova Life Sciences Co., Ltd.Foshan Ionova Biotherapeutics Co., Ltd.
Inactive Organization
Merck Sharp & Dohme LLCIonova Life Science Co., Ltd.Ionova Life Science Co., Ltd.Startup
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with INV-1120
CTR20211872
/ CompletedPhase 1
INV-1120在局部晚期/转移性实体瘤患者中的首次人体、开放式、I期（剂量递增）临床试验
[Translation] A first-in-human, open-label, Phase I (dose-escalation) clinical trial of INV-1120 in patients with locally advanced/metastatic solid tumors
NCT04443088
/ Active, not recruitingPhase 1
A Phase 1a/1b, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Evidence of Antitumor Activity of INV-1120 As a Single Agent and in Combination with Pembrolizumab in Adult Patients with Advanced Solid Tumors
100 Clinical Results associated with INV-1120
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100 Translational Medicine associated with INV-1120
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100 Patents (Medical) associated with INV-1120
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100 Deals associated with INV-1120
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Solid TumorPhase 1
CN
Foshan Ionova Biotherapeutics Co., Ltd.
10 Sep 2021
Advanced Malignant Solid NeoplasmPhase 1
US
Shenzhen Ionova Life Sciences Co., Ltd.
26 Jun 2020
Neoplasm MetastasisPhase 1
US
Shenzhen Ionova Life Sciences Co., Ltd.
26 Jun 2020
Solid tumorPhase 1
US
Ionova Life Science Co., Ltd.Ionova Life Science Co., Ltd.Startup
26 Jun 2020
Solid tumorPhase 1
US
Merck Sharp & Dohme LLC
26 Jun 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
CTR20211872 (ASCO2023)
ManualManual
Phase 1
HR-positive/HER2-low Solid Tumors
9
zgkavmcyen(fqycnqajfq) = kkitpefmlj filrxvxeee (ciqspgrcfk )
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Positive
31 May 2023
(60mg)
zgkavmcyen(fqycnqajfq) = hdkuwurtii filrxvxeee (ciqspgrcfk )
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NCT04443088 (SITC2022)
ManualManual
Phase 1
HR-positive/HER2-low Solid Tumors
24
sfrvrkofrm(nbehqqfley) = ojezrctipr gculvgztzh (kgsuxqbnkx )
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Positive
01 Nov 2022
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Approval

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Regulation

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