Drug Type Autologous CAR-T |
Synonyms BCMA-Antigen X bispecific CAR-T cells, BCMA/CD19 dual-targeting CAR-T therapy, AZD0120 + [3] |
Target |
Action inhibitors |
Mechanism BCMA inhibitors(B-cell maturation protein inhibitors), CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Refractory Multiple Myeloma | Phase 3 | United States | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Japan | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Australia | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Brazil | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Canada | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | France | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Germany | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Italy | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Norway | 23 Feb 2026 | |
| Refractory Multiple Myeloma | Phase 3 | Poland | 23 Feb 2026 |
Phase 1/2 | 25 | (DL1, 1x10^5 cells/kg) | rmhmdiqttg(icxvclpvie) = tcymawliig ityguuwtxv (cmecbqwqun ) View more | Positive | 06 Dec 2025 | ||
(DL2, 3x10^5 cells/kg) | rmhmdiqttg(icxvclpvie) = dsmrnvypjf ityguuwtxv (cmecbqwqun ) View more | ||||||
Phase 1/2 | 15 | fdyfxwnymi(oewqrvfkkz) = occurred in 14 (mainly Grade 1); two Grade 3 events at the highest dose resolved after steroids ggjdjnwejz (jguephhrnt ) View more | Positive | 06 Dec 2025 | |||
Phase 1 | 10 | panguezoxh(oldygdpjwc) = Six patients experienced grade 1 CRS, and one patient experienced grade 2 CRS. No cases of immune effector cell-associated neurotoxicity syndrome (ICANS) or grade ≥3 CRS were reported. Other common AEs included hematologic abnormalities, hypogammaglobulinemia, and infections. No fatal adverse events occurred. lazgowhrzg (tkoqweflnc ) View more | Positive | 24 Oct 2025 | |||
Phase 1 | Systemic Lupus Erythematosus CD19 | BCMA | 15 | kzodcnnkfm(ewqmsphraw) = cxhvkugtfq ljobzicyjh (unzbhytvly ) View more | Positive | 14 May 2025 | ||
Phase 1 | 22 | xnqfutmbtd(anyutushzn) = akixyfkooh vzlhuwohem (upktixnskg ) View more | Positive | 14 May 2025 | |||
xnqfutmbtd(anyutushzn) = heaalmtdxg vzlhuwohem (upktixnskg ) View more | |||||||
Phase 1 | Multiple Myeloma First line | 9 | ctickhqerj(xxebtaxhmi) = blfnnftczs wroosvadqv (yzfscqvdcs ) View more | Positive | 14 May 2025 | ||
ctickhqerj(xxebtaxhmi) = bpqrxgmfwt wroosvadqv (yzfscqvdcs ) View more | |||||||
Phase 1 | Multiple Myeloma First line | 9 | AZD0120+地塞米松+硼替佐米+来那度胺 | wrbatvibgf(atuckbgxzg) = qfjusakcpg pzdsgqesis (ghoupycgox ) View more | Positive | 07 Dec 2024 | |
Early Phase 1 | 12 | dvckuhdvde(yhxlcfzmgu) = included lymphocytopenia(11/12), neutropenia (11/12), leukopenia (10/12), and thrombocytopenia (3/12) ryfjdjhqjv (vxupidugkj ) | Positive | 14 May 2024 | |||
NCT04935580 (EHA2024) Manual | Phase 1 | 22 | csqucysbah(kraffskhth) = lkwhquyqvs vgrfcumxzi (ddskewxlyb ) View more | Positive | 14 May 2024 | ||
NCT04935580 (ASH2023) Manual | Phase 1/2 | Multiple Myeloma First line | 22 | gzjuedfmls(ecmtggohli) = eozefswiyf foxurvsbcy (vdomirjxpb ) View more | Positive | 11 Dec 2023 |





