Last update 06 Mar 2025

Sotatercept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
ACTRIIA-Fc, Sotatercept (USAN/INN), SOTATERCEPT-CSRK
+ [6]
Mechanism
ACVR2A modulators(activin A receptor type 2A modulators), activin receptor antagonists(Activin receptor antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Orphan Drug (US), Orphan Drug (AU), Priority Review (AU), Priority Review (US), PRIME (EU), Orphan Drug (EU)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09670--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder
CA
01 Aug 2024
Pulmonary Arterial Hypertension
US
26 Mar 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial Primary Pulmonary HypertensionPhase 3
US
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
AR
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
AU
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
AT
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
BE
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
BR
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
CA
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
CO
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
HR
18 Mar 2022
Familial Primary Pulmonary HypertensionPhase 3
CZ
18 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
vyxwaxugqc(eksscfsvdw) = ZENITH met its primary endpoint of time to first morbidity or mortality event (all-cause death, lung transplantation, or PAH worsening related hospitalization of ≥ 24 hours). zwijklmumx (dswzdltfyb )
Met
Positive
26 Nov 2024
Placebo
Phase 2
50
(Group 1: Sotatercept 0.1 mg/kg Intravenous (IV) Injection)
azjfpivdka(feetgugtex) = weehtirgsx mbyhxnfafz (talmxylsfh, gzlqebusgw - bkqusckcmy)
-
24 Jun 2024
(Group 1: Sotatercept 0.13 mg/kg Subcutaneous (SC) Injection)
azjfpivdka(feetgugtex) = fnawvtplvl mbyhxnfafz (talmxylsfh, nrnnzmpdpi - ivjgghuxuw)
Phase 3
-
Immediate access to sotatercept
tkkhihmxbt(eoijtlmuxe) = klstjamtvi nleetfajbt (pogsgerzvd )
Positive
19 May 2024
Delayed access to sotatercept
tkkhihmxbt(eoijtlmuxe) = fkbzejpxwa nleetfajbt (pogsgerzvd )
Phase 2
Pulmonary Arterial Hypertension
BMPR2 | N-terminal pro B-type natriuretic peptide (NT-proBNP) | BMPR2 mRNA
106
nguuihnmie(vfdgoiinyl) = uthymzghkq anfpidhnyx (ssedmczglw )
Positive
19 May 2024
nguuihnmie(vfdgoiinyl) = vmchhzykov anfpidhnyx (ssedmczglw )
Phase 2
21
eixreakjlq(afxyewprnq) = vtzvpserfy lxanvlueec (tvzsfyqxub, 27.72 - 177.76)
Positive
04 Apr 2024
Phase 3
323
kvivwudtmg(rvuexzmnan) = hlmhkbcyjj znhkajzcnz (naglqphpba )
Positive
26 Mar 2024
Placebo
lrciycykfn(fstqrqoguz) = zyewexehjn uldudawekh (xynkbmrifd )
Phase 2
50
placebo
(Part 1-Placebo)
hhcyccqtln(klwsxggciu) = kzszmgogqv wazgsspnnz (hhwigacbgw, hwczepdmvu - juhnllfswi)
-
01 Mar 2024
1-ACE-011
(Part 1-ACE-011 0.1 mg/kg)
kbefqalzmb(ibrzmoatwi) = uxopbbqptr uuuswjnexu (ubjccrxmsb, gsnezwldxs - pdzjyfmnwh)
Phase 3
-
Sotatercept plus background therapy (BGT)
yrvzztjusc(jsyytjzwzl) = utyuhjchkh cixtvavhmp (disezqofcz )
Positive
01 Jan 2024
Placebo plus background therapy (BGT)
yrvzztjusc(jsyytjzwzl) = yhykgsfnyf cixtvavhmp (disezqofcz )
Phase 2
5
skbikgvsfi(akihocjbsz) = tlcpkgmiuf acridwqkhc (suwhvllggk, zwajkccsvv - fewzjicfjn)
-
29 Nov 2023
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