A Multicentre, Randomized, Double-Blind, Placebo Controlled, Dose Finding, Parallel Group, Phase 2 Study of an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma

This study is trying to find the right dose of a long-lasting medicine called GSK5784283 for people with asthma that remains uncontrolled even though they are using regular asthma treatments. GSK5784283 blocks the action of an inflammatory protein called TSLP that may be contributing to your asthma. The study will be conducted in two parts - Part A (dose finding phase) and Part B (extended dosing phase). Part A will assess the lung function, asthma control, participant safety and certain markers of asthma inflammation in the air you breath out and in your blood. Part B will assess the safety and long-term effects of the repeated or single doses of GSK5784283.

Start Date04 Mar 2025

Sponsor / Collaborator

GSK Plc

NCT06786455

/ Active, not recruitingPhase 2

Pharmacokinetics, Pharmacodynamics, Safety, and Preliminary Efficacy of Subcutaneous Injection of SHR-1905 in Adolescent Asthmatic Subjects - an Open-label, Single-dose Phase II Clinical Study

Pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy of subcutaneous injection of SHR-1905 in adolescent asthmatic subjects - an open-label, single-dose Phase II clinical study

Start Date23 Jan 2025

Sponsor / Collaborator

Guangdong Hengrui Pharmaceutical Co., Ltd.

CTR20250088

/ Active, not recruitingPhase 2

皮下注射SHR-1905在青少年哮喘受试者中的药代动力学、药效学、安全性和初步疗效研究——开放标签、单次给药II期临床研究

[Translation] Pharmacokinetics, pharmacodynamics, safety and preliminary efficacy study of subcutaneous SHR-1905 in adolescent asthma subjects - an open-label, single-dose phase II clinical study

评估单次皮下（SC）注射SHR-1905在青少年哮喘患者中的药代动力学（PK）特征。评估单次皮下注射SHR-1905在青少年哮喘患者中的安全性。

[Translation]

To evaluate the pharmacokinetic (PK) characteristics of a single subcutaneous (SC) injection of SHR-1905 in adolescent patients with asthma. To evaluate the safety of a single subcutaneous injection of SHR-1905 in adolescent patients with asthma.

Start Date23 Jan 2025

Sponsor / Collaborator

Shanghai Hengrui Pharmaceutical Co., Ltd.

[+1]

100 Clinical Results associated with SHR-1905

100 Translational Medicine associated with SHR-1905

100 Patents (Medical) associated with SHR-1905

Literatures (Medical) associated with SHR-1905

Frontiers in Pharmacology

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects

Article

Author: Qian, Weilin ; Shen, Yu ; McLendon, Kristi ; Fan, Yang ; Shen, Kai ; Fei, Yue ; Li, Na ; Wang, Quanren

Introduction:

Thymic stromal lymphopoietin (TSLP) is integral to inducing innate and T helper two cell inflammation that leads to clinical symptoms of asthma. SHR-1905 is a humanized immunoglobulin G1 kappa monoclonal antibody that inhibits TSLP bioactivity, developed for the treatment of severe uncontrolled asthma. This phase 1, randomized, double-blind, placebo-controlled single ascending dose study assessed the safety, tolerability, pharmacokinetics (PK), and immunogenicity of subcutaneous SHR-1905 in healthy subjects.

Methods:

Five dose cohorts were planned (50, 100, 200, 400, and 600 mg) and subjects were randomized (8:2) in each cohort to receive SHR-1905 or placebo with a follow-up period up to Day 253.

Results:

The majority of treatment-emergent adverse events (TEAEs) were mild and the incidence of TEAEs was comparable between the SHR-1905 and the placebo groups. The maximum serum concentration was reached 7.0–17.6 days after injection. The serum concentration of SHR-1905 increased with increasing dose level, and SHR-1905 exposure exhibited in a slightly greater-than-dose-proportional manner from 50 to 600 mg. SHR-1905 had a prolonged serum half-life around 80 days supporting every 6-month dosing. In SHR-1905 treated subjects, 15% tested positive for anti-drug antibodies post-dose with no apparent effect on corresponding PK profiles or safety.

Conclusion:

SHR-1905 demonstrated a good safety and tolerability profile with a long half-life in healthy subjects after a single administration in the dose range of 50–600 mg.

Clinical Trial Registration::

clinicaltrials.gov, identifier NCT04800263

News (Medical) associated with SHR-1905

03 Mar 2025

·www.fiercepharma.com

Sinusitis data from Amgen, AZ's Tezspire spark 'best-in-disease' talk amid Sanofi, GSK competition

Based on the latest nasal polyps results, Leerink Partners analysts stood by their $4.3 billion Tezspire sales projection for Amgen by 2030. Already billed as a potential blockbuster, Amgen and AstraZeneca’s Tezspire has turned in strong clinical data in chronic rhinosinusitis with nasal polyps (CRSwNP). Tezspire showed numerically better efficacy results in CRSwNP compared with two prominent rivals in the three drugs' separate studies. However, separate teams of analysts at William Blair and Leerink Partners stopped short of handing Tezspire the crown in the indication, citing trial design differences that likely play into the cross-trial comparisons.As Amgen and AZ previously announced, Tezspire significantly improved total nasal polyp score (NPS) and nasal congestion score (NCS) in patients with CRSwNP compared with placebo after 52 weeks in the phase 3 Waypoint study.On NPS, a metric with a range of 0 to 8, treatment with Tezspire led to a placebo-adjusted average improvement of nearly 2.07 points, according to results presented at the joint conference of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization. On NCS, which is scored between 0 and 3, Tezspire performed about 1.03 points better than placebo.The drug also nearly eliminated the need for future surgery and corticosteroid use, Joseph Han, M.D., from the Eastern Virginia Medical School and a co-primary investigator of the Waypoint trial, highlighted in a statement Saturday.Tezspire, which is already approved in severe asthma, didn’t raise any new safety signals, according to investigators. Serious adverse events occurred in 4.9% of Tezspire patients, versus 5.9% in the placebo group.Tezspire’s efficacy numbers came in slightly above Dupixent’s figures from two of its own phase 3 trials, Sinus-24 and Sinus-52. Results from those studies in 2019 enabled the Sanofi and Regeneron antibody to become the first treatment approved by the FDA in inadequately controlled CRSwNP. Dupixent’s 52-week placebo-adjusted difference was 1.8 on NPS and 0.9 on NCS.What’s more, the Tezspire data also look better than results for GSK’s depemokimab. In the phase 3 Anchor-1 and Anchor-2 trials, depemokimab’s 52-week NPS difference amounted to 0.7 points versus placebo. Rather than NCS, the GSK trials used a different co-primary endpoint called verbal response scale to measure nasal obstruction.Based on the results, the Leerink team stood by its $4.3 billion Tezspire sales projection for Amgen by 2030, compared with the consensus estimate of $3 billion. CRSwNP is marked by persistent inflammation of the nasal mucosa, accompanied by nasal polyps, which can block the nose. The inflammatory disease represents a big market, as Dupixent has already achieved blockbuster annual sales in the indication alone, Marion McCourt, commercial chief at Regeneron, said during a conference call last month.The three biologics work in different ways. Tezspire blocks thymic stromal lymphopoietin (TSLP), while depemokimab targets IL-5 and Dupixent inhibits the IL-4/13 axis.“With its first-in-class mode of action, targeting TSLP at the top of the inflammatory cascade, the data add to the body of evidence that [Tezspire] can transform care for patients with epithelial-driven inflammatory diseases,” Sharon Barr, AZ’s head of biopharmaceuticals R&D, said in a statement Saturday.The William Blair analysts said the results “hint at best-in-disease therapy." Importantly, though, both sets of analysis said trial design differences may have impacted the drugs’ relative trial performances.Flagging several nuances in enrollment criteria, Leerink analysts suggested that compared with the Dupixent trials, “Tezspire enrolled a more selective group regarding respiratory comorbidities, but a broader population in terms of prior surgery.”To enroll in Tezspire’s Waypoint trial, patients were required to meet certain bars on NCS and the sino-nasal outcome test (SNOT-22), which measures the symptoms and consequences of rhinosinusitis. GSK’s Anchor trials, which didn’t implement such restrictions, enrolled a “somewhat milder population,” the William Blair team noted.Among the three agents, GSK’s depemokimab appears to have the weakest efficacy numbers—not just on the co-primary endpoint of NPS but also on some secondary endpoints such as change in SNOT-22 score. However, William Blair analysts suggested that the drug’s efficacy may be underestimated given the differences in trial populations.As a twice-yearly therapy, depemokimab boasts a long-acting advantage. Tezspire is dosed subcutaneously every month, while Dupixent is given every other week.“As highlighted by the presenter, patient preference shifts to an injectable therapy over daily orals when the treatment interval is as infrequent as every six months, which could lead to modest commercial uptake in some patients if approved,” William Blair analysts said in a Monday note. Han presented both datasets for Tezspire and depemokimab at AAAAI. During the Q&A session, Han recommended that future trials in CRSwNP incorporate baseline thresholds such as SNOT-22 to focus on moderate-to-severe patients, rather than milder patients who were also allowed in GSK’s Anchor studies, according to William Blair.TSLP as a target has lately attracted much interest, partly thanks to the success of Tezspire. Continuing with its long-acting pursuit, GSK last year bought Aiolos Bio and its anti-TSLP candidate, AIO-001, which the British pharma believes may be dosed once every six months. The candidate was originally licensed from China’s Jiangsu Henguri Pharmaceuticals.Also gunning for a twice-yearly anti-TSLP antibody, Windward Bio emerged earlier this year with a $200 million series A led by OrbiMed, Novo Holdings and Blue Owl Healthcare Opportunities, plus a clinical candidate licensed from China’s Kelun-Biotech and Harbour BioMed.Johnson & Johnson’s $850 million acquisition of Proteologix last year also featured an IL-13/TSLP bispecific. And Upstream Bio could report phase 2 CRSwNP data for verekitug, an antibody targeting the TSLP receptor, later this year.

Clinical ResultPhase 3AcquisitionDrug Approval

03 Mar 2025

·www.gsk.com

GSK enters agreement to acquire Aiolos Bio

GSK plc (LSE/NYSE: GSK) and Aiolos Bio, Inc. (Aiolos) today announced that they have entered into an agreement under which GSK will acquire Aiolos, a clinical-stage biopharmaceutical company focused on addressing the unmet treatment needs of patients with certain respiratory and inflammatory conditions, for a $1 billion upfront payment and up to $400 million in certain success-based regulatory milestone payments. The acquisition provides GSK with access to Aiolos’ AIO-001, a potentially best-in-class, long-acting anti-thymic stromal lymphopoietin (TSLP) monoclonal antibody ready to enter phase II clinical development for the treatment of adult patients with asthma, with potential for additional indications including chronic rhinosinusitis with nasal polyps. AIO-001 was exclusively licensed to Aiolos outside of Greater China by Jiangsu Hengrui Pharmaceuticals Co., Ltd. (Hengrui). Tony Wood, Chief Scientific Officer, GSK, said: “We have a proud heritage and deep development expertise in respiratory medicines, especially addressing diseases driven by IL-5 with high levels of eosinophils or high T2 inflammation. Adding AIO-001, a potentially best-in-class medicine targeting the TSLP pathway, could expand the reach of our current respiratory biologics portfolio, including to the 40% of severe asthma patients with low T2 inflammation where treatment options are still needed.”1 Targeting the TSLP pathway addresses a key driver of the inflammatory response in major allergic and inflammatory diseases. TSLP is a clinically validated target in the treatment of asthma regardless of biomarker status. Early studies of AIO-001 have shown initial safety, tolerability, pharmacokinetics, and biological activity in healthy volunteers and asthma patients. Additionally, AIO-001 has potential to be administered every six months due to its enhanced potency and half-life extension technology, which could redefine the standard-of-care. GSK has an industry-leading portfolio of marketed and investigational medicines to address a range of respiratory diseases, including biologics aimed at treating the subset of asthma patients with high levels of eosinophils or high T2 inflammation. With AIO-001, GSK’s respiratory portfolio could provide the option of a biologic to a broader portion of the 315 million patients living with asthma regardless of biomarker status and including those with low T2 inflammation.2 Khurem Farooq, Chief Executive Officer, Aiolos Bio, said: “We believe that this transaction speaks to the high potential of our long-acting anti-TSLP monoclonal antibody, AIO-001. By uniting with GSK, a leader with decades of experience developing respiratory therapies and a shared commitment to improving patient lives, we’re confident that we can rapidly advance this therapy in the hopes of significantly reducing the treatment burden for patients.” Financial considerations Under the terms of the agreement, GSK will pay a $1 billion upfront payment and up to $400 million in certain success-based regulatory milestone payments. In addition, GSK will also be responsible for success-based milestone payments as well as tiered royalties owed to Hengrui. This transaction is subject to customary conditions, including applicable regulatory agency clearances under the Hart-Scott-Rodino Act in the US. About Aiolos Bio Founded in 2023, Aiolos Bio is a San Francisco, USA and London, UK-based clinical-stage, private, biopharmaceutical company dedicated to revolutionising the treatment landscape for respiratory disease. About AIO-001 AIO-001 is a novel monoclonal antibody with potential for longer dosing intervals, such as every 6 months, due to its half-life extension and differentiated potency. AIO-001 binds to the human thymic stromal lymphopoietin (TSLP) ligand to inhibit TSLP signalling. TSLP has a validated, central role in driving inflammation, including in asthma. About GSK in respiratory For more than 50 years, GSK has led the way in developing medicines that advance the management of respiratory conditions, from introducing the world’s first selective short-acting beta agonist in 1969 to launching 13 respiratory medicines and six vaccines to create today’s industry-leading respiratory portfolio. We are investing in innovative science to transform patient outcomes in existing and new respiratory disease areas and are pushing the frontiers of respiratory science to improve the lives of millions of patients living with respiratory conditions. About GSK GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com. Cautionary statement regarding forward-looking statementsGSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described under Item 3.D 'Risk factors” in the company's Annual Report on Form 20-F for 2022, and Q3 Results for 2023. References [1] Frank C. Albers , Hana Müllerová , Necdet B. Gunsoy , Ji-Yeon Shin , Linda M. Nelsen , Eric S. Bradford , Sarah M. Cockle & Robert Y. Suruki (2018) Biologic treatment eligibility for real-world patients with severe asthma: The IDEAL study, Journal of Asthma, 55:2, 152-160. [2] To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, et al. . Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health (2012) 12:204. The content above comes from the network. if any infringement, please contact us to modify.

06 Nov 2024

·www.prnewswire.com

Severe Asthma Clinical Trial Pipeline Appears Robust With 40+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

The severe asthma market is fueled by the rising prevalence of the condition, particularly in urban areas, alongside the emergence of innovative therapies like biologics targeting IgE and cytokine modulators. A growing demand for personalized medicine enhances treatment efficacy and patient compliance. Government initiatives and increased awareness improve access to care, while advancements in inhaler technology boost medication adherence. Collaborative efforts in R&D are also vital for driving innovation in asthma treatments. LAS VEGAS, Nov. 6, 2024 /PRNewswire/ -- DelveInsight's ' Severe Asthma Pipeline Insight 2024 ' report provides comprehensive global coverage of pipeline severe asthma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the severe asthma pipeline domain. Key Takeaways from the Severe Asthma Pipeline Report DelveInsight's severe asthma pipeline report depicts a robust space with 40+ active players working to develop 50+ pipeline therapies for severe asthma treatment. Key severe asthma companies such as Kinaset Therapeutics, Bio-Thera Solutions, CSPC ZhongQi Pharmaceutical Technology, AB Science, GlaxoSmithKline, Oneness Biotech, Biosion, Lanier Biotherapeutics, Kymera Therapeutics, Suzhou Connect Biopharmaceuticals, Upstream Bio, Teva Branded Pharmaceutical Industries, Sanofi, Jiangsu Hengrui Medicine, AstraZeneca, Advagene Biopharma, Genrix (Shanghai) Biopharmaceuticals, and others are evaluating new severe asthma drugs to improve the treatment landscape. Promising severe asthma pipeline therapies such as KN-002, BAT2606, CM326, Masitinib, GSK3511294, FB 704A, BSI-045B, LNR 125.38, KT 621, CBP-201, Verekitug, TEV'248, Rilzabrutinib, SHR-1905, Atuliflapon, AD17002, GR1802, and others are under different phases of severe asthma clinical trials. In September 2024, Kinaset Therapeutics announced two oral presentations and a late-breaking poster presentation at the 2024 European Respiratory Society (ERS) Congress. The presentations demonstrate the potential of Kinaset's lead clinical candidate, frevecitinib ( KN-002), to treat all patients with moderate to severe asthma and patients with COPD. In May 2024, GSK announced positive headline results from the phase III clinical trials SWIFT-1 and SWIFT-2, which assessed the efficacy and safety of depemokimab versus placebo in adults and adolescents with severe asthma with type 2 inflammation characterized by blood eosinophil count. In April 2024, Twenty-five abstracts across approved and investigational medicines will be presented at this year's American Thoracic Society (ATS) International Conference. Notable data presentations for Sanofi's immunology pipeline include the first presentation of phase IIb moderate to severe asthma data for rilzabrutinib. In October 2023, Upstream Bio announced positive interim results in its Phase Ib clinical study of UPB-101, a thymic stromal lymphopoietin receptor (TSLPR) inhibitor. The Phase Ib study is a randomized, double-blinded, placebo-controlled multiple ascending dose (MAD) study with subcutaneous (SC) administration conducted in asthma patients. In October 2023, Aiolos Bio with an asthma drug in clinical trials, announced that it raised $245 million in Series A funding. Atlas Venture, Bain Capital Life Sciences, Forbion Capital Partners and Sofinnova Investments led the round, with additional investment from RA Capital Management Request a sample and discover the recent advances in severe asthma treatment drugs @ Severe Asthma Pipeline Report The severe asthma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage severe asthma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the severe asthma clinical trial landscape. Severe Asthma Overview Severe asthma is a chronic respiratory condition characterized by persistent symptoms that are difficult to control, even with high-dose medications. Unlike milder forms of asthma, severe asthma can significantly impair the quality of life and may result in frequent exacerbations requiring hospitalization. The exact cause of severe asthma is not entirely clear, but it often arises from a combination of genetic and environmental factors. These may include respiratory infections, allergens (pollen, mold, dust mites), pollutants (tobacco smoke, air pollution), occupational irritants, and lifestyle factors such as obesity and stress. Severe asthma can also develop in people whose milder asthma is not well-controlled over time. Diagnosis of severe asthma begins with a comprehensive medical history, physical examination, and pulmonary function tests like spirometry to assess lung function. Doctors may also order additional tests, such as chest X-rays, blood tests, and allergy tests to identify triggers. A key factor in diagnosing severe asthma is the persistence of symptoms despite the optimal use of standard asthma treatments. Managing severe asthma typically requires a multifaceted approach. Inhaled corticosteroids and long-acting bronchodilators are the mainstays of treatment. For those who do not respond to these medications, biologic therapies (such as omalizumab, mepolizumab, or dupilumab) may be prescribed to target specific pathways involved in the inflammatory response. In addition, patients with severe asthma may benefit from lifestyle modifications, including weight management, avoiding triggers, and pulmonary rehabilitation. In extreme cases, systemic corticosteroids may be necessary, although long-term use can have serious side effects. Find out more about severe asthma treatment drugs @ Drugs for Severe Asthma Treatment A snapshot of the severe asthma Pipeline Drugs mentioned in the report: Learn more about the emerging severe asthma pipeline therapies @ Severe Asthma Clinical Trials Severe Asthma Therapeutics Assessment The severe asthma pipeline report proffers an integral view of the severe asthma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Severe Asthma Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical Therapeutics Assessment By Molecule Type: Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy Therapeutics Assessment By Mechanism of Action: Interleukin 5 receptor antagonists, Thymic stromal lymphopoietin inhibitors, Thymic stromal lymphopoietin inhibitors, Thymic stromal lymphopoietin modulators, Interleukin 6 inhibitors, STAT6 transcription factor degraders, Interleukin 4 receptor alpha subunit antagonists Key Severe Asthma Companies: Kinaset Therapeutics, Bio-Thera Solutions, CSPC ZhongQi Pharmaceutical Technology, AB Science, GlaxoSmithKline, Oneness Biotech, Biosion, Lanier Biotherapeutics, Kymera Therapeutics, Suzhou Connect Biopharmaceuticals, Upstream Bio, Teva Branded Pharmaceutical Industries, Sanofi, Jiangsu Hengrui Medicine, AstraZeneca, Advagene Biopharma, Genrix (Shanghai) Biopharmaceuticals, and others. Key Severe Asthma Pipeline Therapies: KN-002, BAT2606, CM326, Masitinib, GSK3511294, FB 704A, BSI-045B, LNR 125.38, KT 621, CBP-201, Verekitug, TEV'248, Rilzabrutinib, SHR-1905, Atuliflapon, AD17002, GR1802, and others. Dive deep into rich insights for new drugs for severe asthma treatment, visit @ Severe Asthma Drugs Table of Contents For further information on the severe asthma pipeline therapeutics, reach out @ Severe Asthma Treatment Drugs Related Reports Severe Asthma Market Severe Asthma Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key severe asthma companies including AstraZeneca plc, GlaxoSmithKline plc, Sanofi S.A., Novartis AG, Roche Holding AG, Teva Pharmaceutical Industries Ltd., Merck & Co., Inc., Boehringer Ingelheim International GmbH, Regeneron Pharmaceuticals, Inc., Johnson & Johnson, Pfizer Inc., Bristol Myers Squibb, Eli Lilly and Company, Vertex Pharmaceuticals Incorporated, Amgen Inc., AbbVie Inc., Genentech, Inc., Gilead Sciences, Inc., Biogen Inc., CSL Limited, among others. Asthma Market Asthma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key asthma companies including GlaxoSmithKline, 4D Pharma plc, AstraZeneca, Suzhou Connect Biopharmaceuticals, Avillion, Pearl Therapeutics, ARS Pharmaceuticals, Sinomab, Avalo Therapeutics, Kymab, Sanofi, Cumberland Pharmaceuticals, Genentech, Inc. , among others. Asthma Pipeline Asthma Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key asthma companies, including Jiangsu Hengrui Medicine, GlaxoSmithKline, Immunotek SL, AB Science, EMS, Avalo Therapeutics, Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd., ARS Pharmaceuticals, Sanofi, Zura Bio Ltd., AstraZeneca, EURRUS Biotech GmbH, T-Balance Therapeutics GmbH, Gossamer Bio, Aldeyra Therapeutics, Inc., Trio Medicines, Janssen Research & Development, Arrowhead Pharmaceuticals, Hoffman-La-Roche, GlaxoSmithKline, Biohaven Pharmaceutical, TAK-Circulator Co., Shanghai Hengrui Pharmaceutical, among others. Acute Respiratory Distress Syndrome Market Acute Respiratory Distress Syndrome Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key ARDS companies, including MediciNova, Edesa Biotech, Light Chain Biosciences, Boehringer Ingelheim, Genentech, Windtree Therapeutics, Biomarck Pharmaceuticals, Athersys, Healios, Direct Biologics, Biohaven Pharmaceutical, Arch Biopartners, APEPTICO Forschung und Entwicklung GmbH, Staidson (Beijing) Biopharmaceuticals, Veru, Mesoblast Limited, Avalo Therapeutics, Pluristem Therapeutics, ILTOO Pharma, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +14699457679 Logo: SOURCE DelveInsight Business Research, LLP WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical ResultPhase 2Phase 3Phase 1

100 Deals associated with SHR-1905

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Chronic rhinosinusitis with nasal polyps	Phase 2	China	Guangdong Hengrui Pharmaceutical Co., Ltd.	04 Sep 2023
Asthma	Phase 2	China	Shanghai Hengrui Pharmaceutical Co., Ltd.	17 Jan 2023
Respiratory Diseases	Phase 1	Australia	Syneos Health, Inc.	01 Dec 2023
Mild asthma	Phase 1	China	Shanghai Hengrui Pharmaceutical Co., Ltd.	15 Jun 2021
Pulmonary Disease, Chronic Obstructive	IND Approval	China	Guangdong Hengrui Pharmaceutical Co., Ltd.	01 May 2024
Moderate asthma	Preclinical	United States	Aiolos Bio, Inc.	24 Oct 2023
Severe asthma	Preclinical	United States	Aiolos Bio, Inc.	24 Oct 2023

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04800263 (SHR-1905, Pubmed)	Phase 1	TSLP	-	SHR-1905 50 mg	lqtummguev(fuxhusrxpl) = exhibited in a slightly greater-than-dose-proportional manner from 50 to 600 mg wdrskzhrcw (mwjmpxmeui ) View more	Positive	15 Jul 2024
				SHR-1905 600 mg

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis