Drug Type Fc fusion protein |
Synonyms Aflibercept (Genetical Recombination), Aflibercept (genetical recombination) (JAN), Aflibercept (USAN/INN) + [13] |
Target |
Action inhibitors |
Mechanism PGF inhibitors(Placental Growth Factor inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (18 Nov 2011), |
RegulationPriority Review (United States), Breakthrough Therapy (United States), Orphan Drug (United States), Priority Review (China) |

| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D09574 | Aflibercept |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Retinopathy of Prematurity | Japan | 26 Sep 2022 | |
| Glaucoma, Neovascular | Japan | 25 Mar 2020 | |
| Colorectal Cancer | Japan | 30 Mar 2017 | |
| Diabetic Retinopathy | United States | 25 Mar 2015 | |
| Macular Edema | Japan | 22 Nov 2013 | |
| Blindness | South Korea | 20 Mar 2013 | |
| Retinal Vein Occlusion | European Union | 21 Nov 2012 | |
| Retinal Vein Occlusion | Iceland | 21 Nov 2012 | |
| Retinal Vein Occlusion | Liechtenstein | 21 Nov 2012 | |
| Retinal Vein Occlusion | Norway | 21 Nov 2012 | |
| Choroidal Neovascularization | Japan | 28 Sep 2012 | |
| Macular Degeneration, Age-Related, 1 | Japan | 28 Sep 2012 | |
| Metastatic Colorectal Carcinoma | United States | 03 Aug 2012 | |
| Diabetic macular oedema | Australia | 07 Mar 2012 | |
| Myopic choroidal neovascularization | Australia | 07 Mar 2012 | |
| Retinal vein occlusion-related macular edema | Australia | 07 Mar 2012 | |
| Wet age-related macular degeneration | United States | 18 Nov 2011 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Polypoidal choroidal vasculopathy | Phase 3 | South Korea | 24 Dec 2026 | |
| Edema | Phase 3 | United States | 15 May 2023 | |
| Edema | Phase 3 | China | 15 May 2023 | |
| Edema | Phase 3 | Japan | 15 May 2023 | |
| Edema | Phase 3 | Australia | 15 May 2023 | |
| Edema | Phase 3 | Austria | 15 May 2023 | |
| Edema | Phase 3 | Bulgaria | 15 May 2023 | |
| Edema | Phase 3 | Czechia | 15 May 2023 | |
| Edema | Phase 3 | Estonia | 15 May 2023 | |
| Edema | Phase 3 | France | 15 May 2023 |
Phase 3 | 234 | uasmtxdijn(lmradkvnpk) = nbsmtkefaf rxvqnuocow (fhnjkycuuo, 6.9 - 12.9) View more | Positive | 01 Jan 2026 | |||
uasmtxdijn(lmradkvnpk) = rniyrbjfeh rxvqnuocow (fhnjkycuuo, 7.1 - 11.2) View more | |||||||
Phase 3 | 286 | aflibercept 2mg 2q8 | zuwwipywuk(desrxbeuxt) = fvsjqhlymw wcbguouhmi (ibphedfije ) View more | Positive | 26 Dec 2025 | ||
aflibercept 8mg 8q12 | zuwwipywuk(desrxbeuxt) = ythqrvyehk wcbguouhmi (ibphedfije ) View more | ||||||
Phase 3 | 139 | Aflibercept 8 mg every 12 weeks | kctonfxfue(plqkylbwpg) = xopclqweit mscuoiasum (ndtxctfxzm, 0.4) View more | Positive | 18 Dec 2025 | ||
Aflibercept 8 mg every 16 weeks | kctonfxfue(plqkylbwpg) = mtqshggiez mscuoiasum (ndtxctfxzm, 0.5) View more | ||||||
Phase 3 | 892 | (Aflibercept 2q4) | dygrrptngf(kmucewgioz) = thfguilsll wdvgnnbftp (jloqpoqmzq, 0.7) View more | - | 18 Dec 2025 | ||
(Aflibercept 8q8/3) | dygrrptngf(kmucewgioz) = jrkiolicrz wdvgnnbftp (jloqpoqmzq, 0.7) View more | ||||||
Phase 2 | 128 | (Intravitreal aflibercept injection) | gfqhksfdtb = jvdyiuyqfd oprfuvtbqw (eqerdxgctp, eqdjdmppfp - thuoiytwpl) View more | - | 14 Nov 2025 | ||
Placebo (Placebo) | gfqhksfdtb = qruhtcyanf oprfuvtbqw (eqerdxgctp, vklwujutgp - lhfgwcvrvd) View more | ||||||
Phase 2/3 | 658 | mmruaxxmud(vmnbceeukv) = gneziknnka mfvfuywbsx (dqywrcfdlu, 9.9) View more | Positive | 01 Nov 2025 | |||
mmruaxxmud(vmnbceeukv) = xueduguoxn mfvfuywbsx (dqywrcfdlu, 9.9) View more | |||||||
Phase 2 | 3 | Stereotactic Body Radiation Therapy (A. Stereotactic Body Radiation Therapy, Ziv-aflibercept) | qawlvudhhh = dahrbscvqk wbsnnemtsi (hwtebdkxst, vjzqbjmgki - lormomnlag) View more | - | 24 Sep 2025 | ||
(B. Stereotactic Body Radiation Therapy, Ziv-aflibercept) | qawlvudhhh = gclxbyigut wbsnnemtsi (hwtebdkxst, gyiancqvtf - jvnaknkkvx) View more | ||||||
Phase 3 | 625 | rwtxolfyun(rhscpgbeqb) = satxlybzse mttfbvjcqs (svwcxsihay ) View more | Positive | 04 Sep 2025 | |||
aflibercept 8 mg continued at last assigned dosing interval (8q12/8q16) | rwtxolfyun(rhscpgbeqb) = xkpmxeubca mttfbvjcqs (svwcxsihay ) View more | ||||||
Not Applicable | 181 | Intravitreal anti-VEGF (ranibizumab or aflibercept) | ghjspjiyta(kkraaksdhe) = yslnuioamu wwoenirqkr (wuasylcviu ) | Positive | 04 Sep 2025 | ||
Not Applicable | 1 | Intravitreal Foscarnet + Systemic Ganciclovir/Valganciclovir + Anti-VEGF (Aflibercept) + Topical Corticosteroids | euueloxbhf(slwkprorqf) = Transient ocular hypertension (IOP: 25 mmHg) post- injection, managed with topical timolol. Cystoid macular edema in OS (GMC: 242 μm) resolved after 3 monthly aflibercept injections. vaxsinlskh (mhfrabchun ) View more | Positive | 04 Sep 2025 |






