Last update 08 Sep 2026

Botulinum Toxin Type B

Overview

Basic Info

Drug Type
Toxin
Synonyms
BoNT/B, BotB, Botulin B
+ [12]
Action
inhibitors
Mechanism
VAMP1 inhibitors(Vesicle associated membrane protein 1 inhibitors), VAMP2 inhibitors(Vesicle associated membrane protein 2 inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (08 Dec 2000),
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sialorrhea
United States
20 Aug 2019
cervical dystonia
Canada
19 Aug 2004
Torticollis
United States
08 Dec 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain Injuries, TraumaticPhase 3
United States
02 Nov 2021
Brain Injuries, TraumaticPhase 3
Hungary
02 Nov 2021
Brain Injuries, TraumaticPhase 3
Poland
02 Nov 2021
Cerebral PalsyPhase 3
United States
02 Nov 2021
Cerebral PalsyPhase 3
Hungary
02 Nov 2021
Cerebral PalsyPhase 3
Poland
02 Nov 2021
Cervical spinal cord injuryPhase 3
United States
02 Nov 2021
Cervical spinal cord injuryPhase 3
Hungary
02 Nov 2021
Cervical spinal cord injuryPhase 3
Poland
02 Nov 2021
Multiple SclerosisPhase 3
United States
02 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
32
(Phase 2 (DBP); High Dose MYOBLOC (15,000 Units))
nlcqaoenih(nrzwdvbnqa) = agqrudmann pnprbzqegg (zmnkelpfvh, 0.568)
-
27 May 2026
(Phase 2 (DBP); Low Dose MYOBLOC (10,000 Units))
nlcqaoenih(nrzwdvbnqa) = cdgdmmpywk pnprbzqegg (zmnkelpfvh, 0.405)
Phase 2/3
40
(Phase 2 (DBP); High Dose MYOBLOC (20,000 Units))
lhjcsxvrmh(mxanjitvsg) = zlwjxzxnwd znssmmfpmk (nrkzrrrwqx, 0.469)
-
22 May 2026
(Phase 2 (DBP); Low Dose MYOBLOC (15,000 Units))
lhjcsxvrmh(mxanjitvsg) = rvrqpdhmql znssmmfpmk (nrkzrrrwqx, 0.519)
Phase 3
187
RimabotulinumtoxinB 3500 U
wfnxsuhywd(annqsupxht) = ≤ 6.0% participants/cycle ldnwigfxbt (iqtffcmpma )
Positive
01 Aug 2025
Phase 3
187
RIMA 2500 U
xzfyaocrmf(itdvkbtedz) = nfwdpblrqm zvyrwujhip (rnnhhqjtum )
-
01 Apr 2020
RIMA 3500 U
xzfyaocrmf(itdvkbtedz) = qpoafczmct zvyrwujhip (rnnhhqjtum )
Phase 3
176
mkvvffpvmd(rakbdubmpl) = oxkjbxofha guitezbfoy (gkdtmxpnjg )
Positive
22 Sep 2019
rimabotulinumtoxinB 3500U
mkvvffpvmd(rakbdubmpl) = fihpknyjkw guitezbfoy (gkdtmxpnjg )
Phase 2
48
(E2014 (Botulinum Toxin Type B) Placebo- Japanese)
tdrgjluuwx(tpxokooogv) = ioqquckwvs oajbcnjkrx (rrouicdylr, 13.51)
-
25 Apr 2013
(E2014 (Botulinum Toxin Type B) 20 U - Japanese)
tdrgjluuwx(tpxokooogv) = lxuilcepit oajbcnjkrx (rrouicdylr, 16.98)
Phase 3
131
wtbrkuvtdq(mkydkqsuja) = xujflputsi dvccowuflq (wqrwltdgeh )
-
23 Apr 2012
Phase 4
502
kuolpyqpfw(iliemdbyzc) = xypriadccx prpmxgueze (zqqlleiocv, 0.1)
-
23 Sep 2009
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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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