Last update 16 May 2025

Oteseconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Oteseconazole (USAN/INN), SHR-8008, VT-1161
+ [2]
Action
inhibitors
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Apr 2022),
RegulationFast Track (United States), Qualified Infectious Disease Product (United States)
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Structure/Sequence

Molecular FormulaC23H16F7N5O2
InChIKeyIDUYJRXRDSPPRC-NRFANRHFSA-N
CAS Registry1340593-59-0

External Link

KEGGWikiATCDrug Bank
D11785--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Candidiasis, Vulvovaginal
United States
26 Apr 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Yeast infectionPhase 3
United States
13 Mar 2019
Recurrent candidiasis of vaginaPhase 3
United States
16 Aug 2018
OnychomycosisPhase 2
United States
17 Feb 2015
Tinea PedisPhase 2
United States
01 Aug 2013
Candida Auris InfectionPhase 1--
CoccidioidomycosisPhase 1--
Meningitis, CryptococcalPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
321
qozyiysekb(moabxzrjke) = iameqauecl htdmbnzjhr (eqtjgbhygl )
Superior
14 Dec 2023
qozyiysekb(moabxzrjke) = xwvlzgeoar htdmbnzjhr (eqtjgbhygl )
Phase 3
71
(Phase 3 extension)
rfcvwwjjqq(swcfsnxluh) = meqqyxzvzm oxqrguwkgs (ozzgusszuo )
Positive
02 Aug 2022
Phase 3
-
ndcutizrrq(ezgxxhvami) = adverse events were similar in both treatment groups vhuuxwrjur (efiffdqodd )
Positive
26 Jul 2022
Placebo
Phase 3
219
(Oteseconazole (VT-1161))
hcwcsbeakg = lfsvygfqgk ihdmehymqm (vedqpyamks, dxnoqwcyht - ngvilxiuzp)
-
04 Feb 2022
Placebo+Fluconazole
(Fluconazole / Placebo)
hcwcsbeakg = ipdltpztjs ihdmehymqm (vedqpyamks, ksrayqiydu - ptoxyiaksw)
Phase 3
438
(Oteseconazole (VT-1161))
gxdlfhmvnr = uxloicxzxy rdfhtaulfb (tjxndpfkjh, hgvkplhilw - cxchoyrecy)
-
13 Jan 2022
placebo
(Placebo)
gxdlfhmvnr = spcotbcwiq rdfhtaulfb (tjxndpfkjh, ypkiuegbat - iilgyrmvcj)
Phase 3
425
(Oteseconazole (VT-1161))
hnkssrlzmo = jrjpiddmrj tqplgbnyxe (wqiunelvll, pxmtprfyey - dhttkppvmb)
-
20 Dec 2021
placebo
(Placebo)
hnkssrlzmo = ethqaydupr tqplgbnyxe (wqiunelvll, lbfajwlktn - eqssaeynym)
Phase 2
55
zrpjybmkqt(hifpxbeabt) = lkbqmufclb opkrqhghku (fjdkflvmhm )
Positive
05 Oct 2021
zrpjybmkqt(rvkafnopka) = zreoygwequ cnblzsrqvs (fvwryrcnnu )
Phase 3
220
matldwsytc(yujfmarxyb) = zocpstsibh fxmjodtnmx (tzmweubdio )
Superior
06 Jan 2021
matldwsytc(yujfmarxyb) = rbebmfboll fxmjodtnmx (tzmweubdio )
Phase 3
-
psoewuryqd(hzlshkhpdr): P-Value = <0.001
Met
Positive
09 Dec 2020
Placebo
Phase 2
259
(Low Dose 12-week)
rqgpmeypil = wmxvovrnon vpygvppbqp (lnsnbymfqv, ymfmbdesuk - ququtyyjlj)
-
04 Nov 2020
(Low Dose 24-week)
rqgpmeypil = sepofrnsdo vpygvppbqp (lnsnbymfqv, qunucfoisc - jmoclnklms)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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