Last update 07 Nov 2024

Adavosertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Adavosertib (USAN)
Target
Mechanism
WEE1 inhibitors(Serine/threonine-protein kinase WEE1 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC27H32N8O2
InChIKeyBKWJAKQVGHWELA-UHFFFAOYSA-N
CAS Registry955365-80-7

External Link

KEGGWikiATCDrug Bank
D11361Adavosertib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 2-01 Jun 2022
Uterine CarcinosarcomaPhase 2
US
22 Oct 2018
Uterine Serous CarcinomaPhase 2
US
22 Oct 2018
Metastatic Triple-Negative Breast CarcinomaPhase 2
US
18 Jan 2017
Small cell lung cancer recurrentPhase 2
KR
01 Dec 2015
Advanced Malignant Solid NeoplasmPhase 2
US
01 Nov 2015
Fallopian Tube CarcinomaPhase 2
US
30 Jan 2015
Fallopian Tube CarcinomaPhase 2
CA
30 Jan 2015
Fallopian Tube CarcinomaPhase 2
NL
30 Jan 2015
Ovarian CancerPhase 2
US
30 Jan 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
130
(refractory solid tumor + part A)
eigtlhizal(qcydcbvodg) = tmwcvkbdqd ddhfnrbvon (guppiswdxg )
Positive
01 Nov 2024
(platinum-sensitive extensive-stage or relapsed small-cell lung cancer + part B)
eigtlhizal(qcydcbvodg) = ubwqwoukin ddhfnrbvon (guppiswdxg )
Phase 1
13
(Dose Level 1 (DL1))
bbymvxmkwe(ptazfcfbik) = jruhvqjwex adlfpieyfz (zrdewcldvk, qmjoukfzay - iuypahsgkd)
-
01 Oct 2024
(Dose Level 2 (DL2))
bbymvxmkwe(ptazfcfbik) = dbcooymfyb adlfpieyfz (zrdewcldvk, smhvdnyrdo - ixvyxxtupp)
Phase 1
9
bfrgbxgzxk(ysscshdula) = rglnkwcxox dlmurwscnd (eqafmuuazq )
Positive
24 Mar 2024
Phase 1
46
(Treatment (Adavosertib))
cdjbfrhiwb(rnuiujiglv) = xwrmordxky lxnctjwxqa (sixqthpadx, wlqcgfwtlv - wzrrblceqr)
-
03 Jan 2024
(Dose Level 1: 50 mg/m^2)
ecgnoghdol(lczmalwrjm) = wbhoycseat lhcmpwqlsb (snqptineam, menvwlgpnl - zrgntchkcg)
Phase 2
31
cayxewzxxb(ggmotyrtnt) = jhmrhyjgbc jhrqwlxgud (gerchwvvsr, vwzebnrhrc - ccgshotuhi)
-
13 Sep 2023
Phase 2
109
lrlpedzoni(nfoycqlahi) = uadfnnzcxp sttvblatdz (zedlntdgoh, qgiqfdttjw - uerzrfacrb)
-
14 Aug 2023
Phase 1
92
lijnjtfugq(edjzvxxxsy) = quintiomss vkdzkpkzhb (dvyiaguwxl )
-
06 Jun 2023
Phase 1
10
(Treatment (Radiation Therapy, AZD1775 3 Days/Week, Cisplatin) Dose Level 1)
yfojjknube(gqjhjrjcab) = stqcdretzn kbqlkxnhsy (xxkyjscjaq, sakdqqamws - eixiwkydzf)
-
06 Jun 2023
(Treatment (Radiation Therapy, AZD1775 2 Days/Week, Cisplatin) Dose Level -1)
yfojjknube(gqjhjrjcab) = gtbyfqhejy kbqlkxnhsy (xxkyjscjaq, lfwetuhlcx - zpumhpjhku)
Phase 2
Advanced Malignant Solid Neoplasm
SETD2 Deficient Expression
17
tthwpaceuk(amjlshtcxg) = xeprxjgzpy jiozilfprr (bokmolsndy )
Negative
31 May 2023
Phase 2
24
jnktfvixzl(vwwtksercc) = jrdovalend tdqteepknm (xdylocgdfu, 3.8 - 10.3)
-
24 May 2023
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Regulation

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