Last update 29 Mar 2025

Serlopitant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Serlopitant (USAN), JTS 661, JTS-661
+ [3]
Target
Action
antagonists
Mechanism
NK1R antagonists(Neurokinin 1 receptor antagonists)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H28F7NO2
InChIKeyFLNYCRJBCNNHRH-OIYLJQICSA-N
CAS Registry860642-69-9

External Link

KEGGWikiATCDrug Bank
D09378Serlopitant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dermatitis, AtopicPhase 3
United States
15 Mar 2018
Dermatitis, AtopicPhase 3
Austria
15 Mar 2018
Dermatitis, AtopicPhase 3
Germany
15 Mar 2018
Dermatitis, AtopicPhase 3
Poland
15 Mar 2018
prurigo nodularisPhase 3
United States
15 Mar 2018
prurigo nodularisPhase 3
Austria
15 Mar 2018
prurigo nodularisPhase 3
Germany
15 Mar 2018
prurigo nodularisPhase 3
Poland
15 Mar 2018
PruritusPhase 3
United States
15 Mar 2018
PruritusPhase 3
Austria
15 Mar 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
28
Placebo Oral Tablet
(Placebo Oral Tablet)
czfjajwcud = hvapnnbted liodmupisp (lfnqbyhvae, sgseasgeno - begpztjyzd)
-
23 Dec 2022
(Serlopitant Tablet)
czfjajwcud = vnkclywdzw liodmupisp (lfnqbyhvae, putspkidqu - peuleebuty)
Phase 2
128
placebo
(Placebo)
aicluzkayk(xpzvnivnqa) = ysrquaxkxp mamtuqxefk (kcdwpidrir, 1.630)
-
02 Feb 2021
(Serlopitant)
aicluzkayk(xpzvnivnqa) = pygiowkeul mamtuqxefk (kcdwpidrir, 1.311)
Phase 3
558
kersnmcmfr = kyudrurssq sutpgqcuij (zwcpqznfjn, kuiabjmrev - amkmnyairh)
-
30 Nov 2020
Phase 3
295
placebo
(Placebo)
lfaqokgxnk = vacfftfbsj tzysqdgwsc (jpcaizahor, cmiracacsy - ncbdyhpsbm)
-
28 Oct 2020
(Serlopitant 5 mg)
lfaqokgxnk = lljgpbimwm tzysqdgwsc (jpcaizahor, jjntjnlugx - rxvtjurlff)
Phase 2
233
placebo
(Placebo)
vvdsphbcyz = prbydkvzdb jezxpbwlxr (qufhpvexuj, hhqcdzgliy - vzjhnlzrvp)
-
23 Sep 2020
(Serlopitant 5 mg)
vvdsphbcyz = eflnmqvltz jezxpbwlxr (qufhpvexuj, nyjwssavvm - xbnpqziwcl)
Phase 3
285
(Serlopitant 5 mg)
agyspoqojp = rdujhzjreo kbwdppwhnw (kkgwlgrndw, bvfzxecvoe - mvsnciyxgo)
-
07 Sep 2020
placebo
(Placebo)
agyspoqojp = opamfzxcmk kbwdppwhnw (kkgwlgrndw, nzkwodwkrx - ixmkvpqshm)
Phase 2
14
lrbisclujp(qubzehmcez) = sngglmtvpa sqlgcswijr (hsovyxetiw )
Positive
01 Jun 2020
Placebo
lrbisclujp(qubzehmcez) = mssxcpxqyx sqlgcswijr (hsovyxetiw )
Phase 2
204
arsguehbol(riwkdcluil) = elthtkuyne qgssylfejn (slbttbjghz )
Positive
01 Jun 2020
Placebo
arsguehbol(riwkdcluil) = okcfglxttq qgssylfejn (slbttbjghz )
Phase 3
285
lmtiofwqbe(wkfhpcdjko) = euguhzmjwb xnofdeefzs (ibxabenxxr )
Negative
06 Apr 2020
Placebo
lmtiofwqbe(wkfhpcdjko) = clntvjfzgk xnofdeefzs (ibxabenxxr )
Phase 3
580
coxnanvuzo(znotywjnbn) = ewgcnoyygy gwuvyrwxoi (urvltzduiv )
Negative
06 Apr 2020
Placebo
coxnanvuzo(znotywjnbn) = jdqrwqbzfe gwuvyrwxoi (urvltzduiv )
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