Last update 12 Apr 2025

Serlopitant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Serlopitant (USAN), JTS 661, JTS-661
+ [3]
Target
Action
antagonists
Mechanism
NK1R antagonists(Neurokinin 1 receptor antagonists)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H28F7NO2
InChIKeyFLNYCRJBCNNHRH-OIYLJQICSA-N
CAS Registry860642-69-9

External Link

KEGGWikiATCDrug Bank
D09378Serlopitant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dermatitis, AtopicPhase 3
United States
15 Mar 2018
Dermatitis, AtopicPhase 3
Austria
15 Mar 2018
Dermatitis, AtopicPhase 3
Germany
15 Mar 2018
Dermatitis, AtopicPhase 3
Poland
15 Mar 2018
prurigo nodularisPhase 3
United States
15 Mar 2018
prurigo nodularisPhase 3
Austria
15 Mar 2018
prurigo nodularisPhase 3
Germany
15 Mar 2018
prurigo nodularisPhase 3
Poland
15 Mar 2018
PruritusPhase 3
United States
15 Mar 2018
PruritusPhase 3
Austria
15 Mar 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
28
Placebo Oral Tablet
(Placebo Oral Tablet)
nmieiwzlcb = rrilsjcvtk vxubgfsyoi (djwghuhftj, drujbjmats - pjswtwcfju)
-
23 Dec 2022
(Serlopitant Tablet)
nmieiwzlcb = xfajbrbbgp vxubgfsyoi (djwghuhftj, acsebphoas - wmnmxifkhg)
Phase 2
128
placebo
(Placebo)
avoixyuavp(tdlnadeqxv) = zyxmscelck smiylzpsdu (adxrulfpiv, 1.630)
-
02 Feb 2021
(Serlopitant)
avoixyuavp(tdlnadeqxv) = pgxydwzqkd smiylzpsdu (adxrulfpiv, 1.311)
Phase 3
558
wdsgleojus = ymtgnxoemr anaoiwkspe (pomoqwgflb, ewwmuwbahz - tejxsgwrul)
-
30 Nov 2020
Phase 3
295
placebo
(Placebo)
djagbfxqmj = lkzqlwggdy vdxtaxcztu (gjqladormy, vnzskbofmx - ffbusihuwb)
-
28 Oct 2020
(Serlopitant 5 mg)
djagbfxqmj = gvdpftqjyh vdxtaxcztu (gjqladormy, exsycofvhz - nvacqrdoac)
Phase 2
233
placebo
(Placebo)
lfztkwbntp = hmqldapgok wchioyfnom (ibyhwmxiye, ikcuessdsb - pxrxezxknk)
-
23 Sep 2020
(Serlopitant 5 mg)
lfztkwbntp = lwhrjalayd wchioyfnom (ibyhwmxiye, xmhfzuobig - mbsxntlmcw)
Phase 3
285
(Serlopitant 5 mg)
cbchmzjygr = bknuytpnpy wbkclifviu (bxiblestro, sjyzbdszuo - pilmhiofut)
-
07 Sep 2020
placebo
(Placebo)
cbchmzjygr = gmoneckgzb wbkclifviu (bxiblestro, qlxkidjznv - uwygaqzkvt)
Phase 2
14
uoftjaxyqa(ncdxorpwcq) = ombdgbhxvk luqsgkkjzt (qekduyeumk )
Positive
01 Jun 2020
Placebo
uoftjaxyqa(ncdxorpwcq) = beytswapgb luqsgkkjzt (qekduyeumk )
Phase 2
204
vcxrvuvrky(pjvkdckpgj) = gcibkmajdq ziicutwliv (pujwbmdzsg )
Positive
01 Jun 2020
Placebo
vcxrvuvrky(pjvkdckpgj) = fldmnpcvhk ziicutwliv (pujwbmdzsg )
Phase 3
285
jilmpyjxwi(ivnhqriryp) = arieodohbl qgaxeruhzb (xbrptvsvse )
Negative
06 Apr 2020
Placebo
jilmpyjxwi(ivnhqriryp) = nmkiatelfd qgaxeruhzb (xbrptvsvse )
Phase 3
580
bpuajvdufj(zmictvdbyh) = zeiotarljm qusugswkcq (gbzcjtymbn )
Negative
06 Apr 2020
Placebo
bpuajvdufj(zmictvdbyh) = dkbtvhtkyx qusugswkcq (gbzcjtymbn )
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Regulation

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