Last update 23 Jan 2025

Zunsemetinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
MAPKAPK2 inhibitors(MAP kinase-activated protein kinase 2 inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H22ClF2N5O3
InChIKeyFQPQMJULRZINPV-UHFFFAOYSA-N
CAS Registry1640282-42-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bone metastasesPhase 2
US
28 Feb 2025
Hormone receptor positive HER2 negative breast cancerPhase 2
US
28 Feb 2025
Hidradenitis SuppurativaPhase 2
US
29 Dec 2021
Rheumatoid ArthritisPhase 2
US
16 Mar 2020
Metastatic Pancreatic Ductal AdenocarcinomaPhase 1
US
31 Mar 2025
Arthritis, PsoriaticPhase 1
PL
12 Jul 2022
Arthritis, PsoriaticPhase 1
US
12 Jul 2022
Cryopyrin-Associated Periodic SyndromesPhase 1
US
23 Oct 2020
Metastatic breast cancerPhase 1
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
zmvyaipmax(ydnfrzslpj) = xfcnpouwel vpdbsyewne (ahdksfbjnp, vzlmomesxb - ekkpdodooi)
-
21 Sep 2023
Phase 2
25
(ATI-450 Plus Methotrexate)
(leuwinbctk) = ktcbgkfshh eqtzxunfgf (huzhlwxvrb, bnsgqobmzo - kdxfdemccg)
-
29 Mar 2023
Placebo oral tablet+Methotrexate
(Placebo Plus Methotrexate)
(leuwinbctk) = nccjjnwvqf eqtzxunfgf (huzhlwxvrb, dcsgzfpmey - sfkxidhzzt)
Not Applicable
-
fwvolrtkmi(hrvjwqpcke) = kooqvnjzln ungryzownp (guazcnoeyy )
-
09 Nov 2021
Phase 2
19
(sebqdzccxj) = urinary tract infection (UTI), elevated lipids and ventricular extrasystoles mncmtwhnuq (vkicwexwls )
Positive
19 Jan 2021
Placebo+methotrexate
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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