Last update 21 Nov 2024

Durcabtagene autoleucel

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-BCMA CAR-T Cell Therapy - Novartis Pharmaceuticals, a B-cell maturation antigen (BCMA)-directed, genetically engineered T cell immunotherapy product derived from an autologous leukapheresis
+ [1]
Target
Mechanism
BCMA inhibitors(B-cell maturation protein inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 2
AU
03 Mar 2022
Multiple MyelomaPhase 2
GR
03 Mar 2022
Multiple MyelomaPhase 2
IL
03 Mar 2022
Multiple MyelomaPhase 2
CA
03 Mar 2022
Multiple MyelomaPhase 2
FR
03 Mar 2022
Multiple MyelomaPhase 2
ES
03 Mar 2022
Multiple MyelomaPhase 2
BR
03 Mar 2022
Multiple MyelomaPhase 2
GB
03 Mar 2022
Multiple MyelomaPhase 2
DE
03 Mar 2022
Multiple MyelomaPhase 2
IT
03 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Multiple Myeloma
sBCMA | circulating EVs
19
ltczjutpqe(pudsjseixh) = The presence of BCMA was observed and quantified in circulating EVs (these EVs were characterized by canonical EV-associated proteins). In most patients, the BCMA-content of plasma EVs showed a similar dynamic profile to that shown by sBCMA. suzqklilnz (zpurtwkuzu )
-
14 May 2024
Phase 1
46
(bweypixuqq) = Dose limiting toxicities were experienced by 13% of pts and included gr 4 neutropenia, gr 4 lipase increase, gr 3 serum amylase increase, gr 3 neurotoxicity, gr 3 transaminitis, and gr 3 ejection fraction reduction. jfsorserpc (rurzfcmbdl )
Positive
26 May 2023
Phase 1
22
(jgmdsyvvyo) = nkuyauipzr vbweqlrywr (jcqppysmfo )
Positive
12 May 2022
Phase 1
7
PHE-885
(wdwdiiurvl) = kwlthauskt fncxkauezh (xqlwnjbgnf )
Positive
05 Nov 2021
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Approval

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Regulation

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