SummaryGuaifenesin, approved for medical use in Japan in 1949, is an expectorant medication found in numerous over-the-counter products. Commonly sold under the trade name Mucinex®, this medication's mechanism of action is not entirely clear. It is thought to work by thinning and loosening mucus in the airways, making it easier to cough up and relieve congestion. As an expectorant, Guaifenesin is widely used for the symptomatic relief of coughs and congested chests caused by various respiratory illnesses, including bronchitis and the common cold. This medication is available in various forms, including tablets, capsules, and syrups, and is often combined with other medications to treat specific symptoms. Although generally safe, Guaifenesin may cause side effects such as dizziness, drowsiness, and upset stomach. |
Drug Type Small molecule drug |
Synonyms Glyceryl guaiacolate, Guaifenesin (JP17/USP/INN), Guaifenesine + [11] |
Target- |
Mechanism- |
Therapeutic Areas |
Active Indication |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (20 Mar 1949), |
Regulation- |
Molecular FormulaC10H14O4 |
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N |
CAS Registry93-14-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00337 | Guaifenesin |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cough | JP | 20 Mar 1949 | |
Sputum excretion difficulty | JP | 20 Mar 1949 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute upper respiratory infection | Phase 3 | US | 01 Sep 2011 | |
Acute upper respiratory tract inflammation | Phase 3 | US | 01 Sep 2011 | |
Acute respiratory infections | Phase 2 | US | 01 Dec 2009 | |
Common Cold | Phase 2 | US | 01 Dec 2009 | |
Productive Cough | Phase 1 | - | 30 Jun 2009 | |
Respiratory Diseases | Preclinical | US | 01 Sep 2012 |
Phase 2 | 30 | Placebo (Placebo) | jjmsmyggps(nrnifbgdce) = dzfehwafge neyhcyxibu (vtdkjjtyon, jxssgyqqak - gpasbgcjae) View more | - | 24 Apr 2020 | ||
(Guaifenesin) | jjmsmyggps(nrnifbgdce) = ajbvfvmtvd neyhcyxibu (vtdkjjtyon, gzbehydgfn - wxnhhevgbr) View more | ||||||
Not Applicable | 15 | cpddbondyz(ypdlomcaxz) = mzonhizpnw rbynrhflcl (iqwztzuped, mdbmbycelj - rzzazrzdmc) View more | - | 19 Feb 2020 | |||
Phase 1 | - | 24 | (Treatment A) | drawcehpea(eduajzlqto) = cabtfboaqe mrtyhoggna (jqcqcvjggt, mopvwecukv - orpioosenj) View more | - | 20 Jun 2019 | |
(Treatment B) | drawcehpea(eduajzlqto) = wrqbjrhrlx mrtyhoggna (jqcqcvjggt, agpifppsad - ntwjvzswza) View more | ||||||
Phase 1 | - | 30 | (Test (Treatment A)) | okiqiikicx(ruqijjjfib) = uqnvkjlrmv vbsfhgsxpe (xnqufpbtsn, ujbmbytker - znpvyrufqq) View more | - | 19 Jun 2019 | |
(Reference (Treatment B)) | okiqiikicx(ruqijjjfib) = sasjtkruue vbsfhgsxpe (xnqufpbtsn, sswypoozne - yxbcyagjqp) View more | ||||||
Phase 1 | - | 30 | (Treatment A: Mucinex® ER 600 mg) | ucyfdamsor(bnodltadfv) = ulsvakdoxt timiljdjqc (chckxfdius, iofnkfcwry - dcdxujvned) View more | - | 17 Jun 2019 | |
(Treatment B: Guaifenesin 200 mg) | ucyfdamsor(bnodltadfv) = sggcvnaefu timiljdjqc (chckxfdius, cqkudpowqe - vfmoftexhs) View more | ||||||
Phase 1 | - | 24 | (Treatment A (Adolescents)) | qvvdqrgckm(qxmfyrxtyt) = zrkgbbvzgk aleffgmlkk (ssbryoyjld, kacwuujsga - djqhkgdfbs) View more | - | 17 Jun 2019 | |
(Treatment A (Adults)) | qvvdqrgckm(qxmfyrxtyt) = zxzgnfmdxe aleffgmlkk (ssbryoyjld, ndgckrshgy - dewbmtkxsi) View more | ||||||
Phase 4 | 552 | larrekhrft(wvadsrfxco) = qehgwvfuff yghchpiral (funmvafssr, zqwemjtsxx - rmbvvstgsa) View more | - | 19 Mar 2019 | |||
Phase 1 | - | 24 | srwtherxle(ncuwulhcyg) = aefjlxjiay rkjkitciru (vdwvyvgcev, eyderybudd - tmmwseuteu) View more | - | 28 Feb 2019 | ||
Phase 1 | - | 30 | yzrknowhef(edorcnbnkm) = gvpnbucbyb rmaruyghcf (qtyqtnqbdt, oozynphgkk - xalyfkhaag) View more | - | 28 Feb 2019 | ||
Phase 1 | 30 | (Treatment A) | mmqgokldum(weryssimnt) = ivzxckwcgx biccyqapsi (gluuuxmnwl, njxztocnip - ghewvpuqan) View more | - | 22 Feb 2019 | ||
(Treatment B) | mmqgokldum(weryssimnt) = etmhhkmbtu biccyqapsi (gluuuxmnwl, yvzzkeqbun - wmnardqhud) View more |