Delving into the Latest Updates on Vitis rotundifolia Skin Extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

MSKE, Muscadine Grape Skin Extract, Muscadine Plus

Target-

Mechanism-

Therapeutic Areas

NeoplasmsUrogenital Diseases

Active Indication

Non-metastatic prostate cancerAdvanced cancerUnresectable Malignant Solid Neoplasm

Inactive Indication

Adenocarcinoma of prostate

Originator Organization-

Active Organization

National Cancer Institute

Huntsman Cancer Institute

The Johns Hopkins University

+ [1]

Inactive Organization

The Sidney Kimmel Comprehensive Cancer Center

Drug Highest PhasePhase 3

First Approval Date-

Regulation-

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This phase I trial studies the side effects and the best dose of muscadine grape skin extract (MGE) in treating patients with malignancy (tumor or cancer) that has spread to other parts of the body or cannot be removed by surgery. MGE is a nutritional supplement containing an extract of the skin of muscadine grape that has shown anti-cancer activity in laboratory studies and may be able to fight or kill malignant cells.

Start Date01 Mar 2016

Sponsor / Collaborator

Wake Forest School of Medicine

[+1]

NCT01317199 / CompletedPhase 1/2IIT

Phase I/II Study of Safety and Efficacy of Muscadine Plus (MPX) in Men With Prostate Cancer: a Randomized,Double-blind,Placebo Controlled Study of the Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

This research is being done to test an investigational product called Muscadine Plus in the treatment of men who have received initial therapy (surgery and or radiation, cryotherapy or brachytherapy) for prostate cancer and are experiencing a rise in their prostate-specific antigens (PSA) level.

Start Date01 Jul 2011

Sponsor / Collaborator

The Sidney Kimmel Comprehensive Cancer Center

[+2]

100 Clinical Results associated with Vitis rotundifolia Skin Extract

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100 Translational Medicine associated with Vitis rotundifolia Skin Extract

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100 Patents (Medical) associated with Vitis rotundifolia Skin Extract

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38

Literatures (Medical) associated with Vitis rotundifolia Skin Extract

01 Jun 2021·American Journal of Clinical OncologyQ4 · MEDICINE

Phase I Study of Muscadine Grape Extract for Patients With Advanced Cancer

Q4 · MEDICINE

Article

Author: Tooze, Janet A. ; Klepin, Heidi D. ; Alistar, Angela T. ; Pleasant, Katherine ; Bitting, Rhonda L. ; Thomas, Christopher Y. ; Isom, Scott ; Petty, W. Jeffrey ; Golden, Shannon L. ; Chappell, Mark C. ; Tallant, E. Ann ; Thomas, Alexandra ; Gallagher, Patricia E. ; Grant, Stefan C. ; Desnoyers, Rodwige J.

Objective:Preclinical studies with muscadine grape extract (MGE) show antitumor activity and decreased systemic inflammation. This phase I study (NCT02583269) assessed safety and tolerability of a proprietary MGE preparation in patients with advanced solid tumors.Methods:Patients with metastatic or unresectable cancers who were progressing on standard therapies were assigned to MGE in a standard 3+3 design. Five dose levels were tested (320 to 1600 mg total phenolics/d). Safety and maximum-tolerated dose were assessed after 4 weeks. Patients were evaluated for response at 8 weeks and continued on MGE if clinically stable. Secondary outcomes were response, survival, adherence, fatigue, and quality of life (QOL).Results:In total, 23 patients (lung, n=7; gastrointestinal, n=7; genitourinary, n=6; other, n=3) received MGE capsules by mouth twice daily. The cohort [median age 72 years, 48% Eastern Cooperative Oncology Group (ECOG) 2] was heavily pretreated. After 4 weeks on MGE, possibly attributable adverse events grade 2 or higher were fatigue (n=1), decreased lymphocyte count (n=1), and constipation (n=2), including 1 dose-limiting toxicity for grade 3 constipation. Maximum-tolerated dose was not reached. No partial responses were observed. Median time on therapy was 8 weeks, with 29% of patients treated beyond 16 weeks and a median overall survival of 7.2 months. QOL and fatigue levels were stable from baseline to 8 weeks. Higher MGE dose was correlated with improvement in self-reported physical well-being QOL at 8 weeks (r=0.6; P=0.04).Conclusions:MGE is safe and well-tolerated in heavily pretreated and older cancer patients. The potential anticancer properties and the effects of MGE on physical well-being and QOL metrics will be evaluated in future studies.

01 Sep 2020·Phytopathology®Q2 · AGRICULTURAL & FORESTRY SCIENCE

Grapevine Resistance to the NematodeXiphinema indexIs Durable in Muscadine-Derived Plants Obtained from Hardwood Cuttings but Not from In Vitro

Q2 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Khallouk, Samira ; Lafargue, Maria ; Van Ghelder, Cyril ; Banora, Mohamed Youssef ; Esmenjaud, Daniel ; Portier, Ulysse ; Tandonnet, Jean-Pascal ; Ollat, Nathalie ; Nguyen, Van Chung

Breeding for varieties carrying natural resistance (R) against plant-parasitic nematodes is a promising alternative to nematicide ban. In perennial crops, the long plant−nematode interaction increases the risk for R breaking and R durability is a real challenge. In grapevine, the nematode Xiphinema index has a high economic impact by transmitting Grapevine fanleaf virus (GFLV) and, to delay GFLV transmission, rootstocks resistant to this vector are being selected, using Muscadinia rotundifolia in particular as an R source. To optimize in fine this strategy, the durability has been studied under controlled conditions in F1 and BC1 muscadine-derived resistant accessions previously obtained from either hardwood-cutting or in vitro propagation. After inoculation with a mix, in equal proportions, of four lines representative of the X. index diversity, multiplication on plants has been monitored 3 to 6 years. The nematode reproduction factor remained lower than 1 in resistant plants obtained from hardwood cuttings while it increased at values far beyond 1 in resistant plants of in vitro origin. Data for nematode numbers per gram of roots mostly paralleled those obtained for the reproduction factor. The effect of the propagation type on resistance over years was also evaluated for the ratio female/juvenile and the frequency of males. Altogether our results illustrate that the muscadine-derived resistance based on hardwood cuttings is durable. By contrast, in resistant and reference accessions obtained from in vitro, our data suggest that the increased nematode multiplication might be mainly due to the modification of root architecture consecutive to this propagation method.

01 Jun 2019·Journal of Food BiochemistryQ3 · AGRICULTURAL & FORESTRY SCIENCE

Comparison of non‐anthocyanin polyphenol accumulation in the berry skins of muscadine and European grapes during ripening in China

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Wei, Zheng ; Huang, Yu ; Qu, Junjie ; Yin, Ling ; Song, Shiren ; Zhang, Yali ; Guo, Wenfeng ; Lu, Jiang

The non-anthocyanin polyphenol accumulation in the berry skins of muscadine grapes from South China during ripening was investigated, in comparison to European grapes, for two consecutive years, using ultra-performance liquid chromatography tandem triple quadrupole time-of-flight mass spectrometry. A total of 121 components were tentatively identified, consisting of 48 ellagic acids and precursors (EP), 38 flavonols, 20 hydroxybenzoic acids, 6 hydroxycinnamic acids, 5 flavan-3-ols, and 4 stilbenes. EP (mostly ellagic acid derivatives) and flavonols (mainly isorhamnetin and quercetin derivatives) were, respectively, accumulated abundantly in the muscadine and European grape skins. Additionally, their variation had considerable differences during berry maturation. EP in muscadine cv. "Noble" skins showed a small decrease before veraison and a slight increase post-veraison, yet the flavonols significantly increased as berry maturation in European skins, with a few exceptions. This is the interactional result between genotype and environmental factors, which obviously influences the polyphenol composition and concentration. PRACTICAL APPLICATIONS: Muscadine grapes, indigenous to the southeast of United States, have been introduced to South China in recent years. These grapes have unique polyphenol composition that differs from non-muscadine grapes. Their polyphenol properties have been studied extensively in many but there are a few studies in our knowledge about the variation of these compounds at different berry developmental stages. This article evaluates the accumulation of non-anthocyanin polyphenols in muscadine skins during berry maturation, in comparison to European grapes. The findings exhibit the polyphenol characteristics of these grapes cultivated in new locations across South China, and make further efforts to increase breeding quality and agronomic production, through improving preharvest treatments and agronomic performance during berry developmental stages, that lead to a high increase of polyphenol.

100 Deals associated with Vitis rotundifolia Skin Extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Non-metastatic prostate cancer	Phase 3	US	The Johns Hopkins University	25 Jan 2024
Non-metastatic prostate cancer	Phase 3	US	Huntsman Cancer Institute	25 Jan 2024
Non-metastatic prostate cancer	Phase 3	US	Hope Medical Center	25 Jan 2024
Advanced cancer	Phase 1	US	National Cancer Institute	01 Mar 2016
Unresectable Malignant Solid Neoplasm	Phase 1	US	National Cancer Institute	01 Mar 2016
Adenocarcinoma of prostate	Discovery	US	The Sidney Kimmel Comprehensive Cancer Center	30 Oct 2018

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02583269 (ASCO2018)	Phase 1	Advanced cancer	23	Muscadine grape extract	yiryzyblqn(bualtrtxhh) = ksyvhgifdo oguozwvyei (pmuytzgcfu ) View more	-	01 Jun 2018
NCT01317199 (ASCO_GU2014)	Phase 1	Non-metastatic prostate cancer	14	Muscadine Grape Skin (MPX)	fhttoruadr(skxgyfvasp) = ncxrhybhds fhhasehihc (obngpiyoak )	-	01 Feb 2014
NCT01317199 (ASCO_GU2014)	Phase 1	Non-metastatic prostate cancer	14	Placebo	fhttoruadr(skxgyfvasp) = pkyysxndbj fhhasehihc (obngpiyoak )	-	01 Feb 2014