A Comparison Between the Ocular Surface of Different Concentrations of Benzalkonium Chloride Preservative in Postoperative Topical Medications After Cataract Surgery

study the effect of different concentrations of benzalkonium chloride on the ocular surface of non-dry-eyed patients post cataract surgery.

Start Date10 Jan 2024

Sponsor / Collaborator

Qasr El Eyni Hospital

100 Clinical Results associated with Netilmicin Sulfate

100 Translational Medicine associated with Netilmicin Sulfate

100 Patents (Medical) associated with Netilmicin Sulfate

4,878

Literatures (Medical) associated with Netilmicin Sulfate

01 Dec 2025·Molecular Biology Reports

Genomic characterization and identification of multiple drug resistance genes in clinical isolates of Acinetobacter baumannii through whole genome sequencing

Article

Author: Mustafa, Abu Salim ; Habibi, Nazima ; Al-Obaid, Inaam ; Khan, Mohd Wasif ; Alfouzan, Wadha ; Nasser, Kother ; Uddin, Saif

BACKGROUNDAcinetobacter baumannii is a notorious nosocomial pathogen universally in healthcare settings. Its natural competent characteristics for genetic recombination are responsible for acquired antibiotic resistance and render it untreatable through commonly used antibiotics. Hence, characterizing the A. baumannii genomes for multidrug resistance carriage is of paramount importance. The study aimed to characterize the whole genome of clinical isolates of A. baumannii to identify specifically the types of antibiotic resistance genes, drug classes and mobile genetic elements. We also aimed to determine the significant multi-locus sequence tags (MLSTs). The phylogeny of the isolates was established with other clinical strains distributed globally.METHODS AND RESULTSFifteen clinical isolates (isolated from tracheal secretion, urine and bronchoalveolar lavage) were subjected to whole genome sequencing. Raw sequences were assembled using SPAdes and species were identified using KmerFinder 3.2. The assembled genomes were annotated using the Prokka v1.14.6. Resfinder 4.6.0 was used to determine antibiotic resistance genes. The sequences were aligned against seven housekeeping genes aka sequence tags (STs) available within the MLST database (v 2.0.9). MobileGeneticElement finder (v1.0.3) were used for profiling mobile genetic elements associated with the antibiotic resistance genes. The genomes of nosocomial A. baumannii were assembled with an average N50 of 23,480 and GC content of 38%. There were approximately 3700 CDs, 53 tRNA and 3 rRNA. About 80% of the isolates were ST2 type. The genomes possessed antibiotic resistance genes (n = 24) belonging to 17 drug classes. The predicted phenotype was multidrug resistant. Among the mobile genetic elements, 12 insertion sequences and 2 composite transposons were also found. The mode of antibiotic resistance was mostly through antibiotic inactivation in all the isolates.CONCLUSIONSThe results imply the occurrence of multidrug resistant genes in clinical isolates of A. baumannii strains in the healthcare settings of Kuwait. A more comprehensive survey should be undertaken for antimicrobial resistance monitoring on a regular basis for surveillance, contact tracing, and potential mitigation in clinical settings.

01 May 2025·European Journal of Ophthalmology

The efficacy of a netilmicin/dexamethasone gel combination in the treatment of posterior blepharitis in moderate-severe dry eye patients

Article

Author: Palino, Paola ; Inferrera, Leandro ; Oliverio, Giovanni William ; Postorino, Elisa I ; Aragona, Pasquale

PurposeTo evaluate the safety and efficacy of netilmicin/dexamethasone combination in the treatment of meibomian gland dysfunction (MGD)-associated posterior blepharitis.MethodsIn this prospective and controlled study were enrolled 40 patients with MGD and symptoms of dry eye disease. Two groups were established: 20 patients (group 1) received netilmicin 3 mg/ml and dexamethasone 1 mg/ml eye gel, whereas in group 2 (20 patients) received vehicle for 15 days. Patients were evaluated at baseline, 15 and 45 days, including SANDE and VARS questionnaire, non-invasive tear film breakup time (NIBUT), tear meniscus height (TMH), ocular redness and meibography score. Moreover, fluorescein tear-film breakup time (TBUT), fluorescein ocular surface staining, lid margin evaluation including hyperemia, edema and meibum expressibility and quality examinations were carried out. Furthermore, intraocular pressure (IOP) and best-corrected visual acuity (BCVA) were considered as safety parameters.ResultsIn group 1, at 15 and 45 days there were statistically significant changes in VARS and SANDE score (p < 0.0001) as well as lid margin parameters, TBUT and fluorescein ocular surface staining (p < 0.0001). Comparing the two groups, a significant improvement of SANDE score was observed at 15 days in group 1 as well as lid margin parameters, TBUT and fluorescein ocular surface staining at 15 and 45 days (all p < 0.0001).ConclusionNetilmicin/dexamethasone combination is effective and safe to treat MGD-associated posterior blepharitis improving both symptoms and ocular surface signs.

01 Apr 2025·Food Science and Biotechnology

Biofilm formation, slime production, and antibiotic susceptibility properties of the Bacillus cereus group isolated from fresh vegetables in the Republic of Korea

Article

Author: Yoon, Jae-Hyun ; Lee, Sun-Young ; Song, Hana

This study aimed to characterize the ability of the Bacillus cereus group isolated from conventionally, organically or pesticide-freely grown vegetables to form biofilms with regard to cell surface hydrophobicity (CSH), slime production, and antibiotic susceptibility. Cellular properties (biofilm formation, CSH, and slime production) were measured using an in vitro microplate assay with crystal violet staining, adhesion to hydrocarbons assay, and Congo red broth method, respectively. Consequently, 16, 16, and 16 B. cereus strains were isolated from conventionally, organically, and pesticide-freely grown vegetables, respectively, and 16 (33%) B. cereus isolates were highly biofilm-positive producers. CSH values dramatically varied, ranging from 19 to 74%, among the B. cereus isolates. Additionally, 9, 8, and 8 B. cereus strains isolated from conventionally, organically, and pesticide-freely grown vegetables, respectively, were identified to be slime-positive producers. According to the disc diffusion method, 19 and 41 B. cereus isolates were highly resistant to ampicillin and penicillin, respectively.

100 Deals associated with Netilmicin Sulfate

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KEGG	Wiki	ATC	Drug Bank
D00867	Netilmicin Sulfate	J01GB07 S01AA23	DB00955

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Indication	Country/Location	Organization	Date
Bacterial Infections	China	Fujian Nanshaolin Pharmaceutical Co., Ltd.	01 Jan 1993

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2021	Not Applicable	Keratitis	794	Netilmicin	soskertdpy(axlovktzrx) = sdjzzprofw daugdcufhe (cynwnrvsdo ) View more	Positive	01 Jun 2021
				Moxifloxacin	soskertdpy(axlovktzrx) = onbvwxzfpb daugdcufhe (cynwnrvsdo ) View more
ARVO2019	Not Applicable	-	-	netilmicin (Staphylococcus aureus)	pajxsvrztm(wxbzymaxvv) = ftpabtiuoa fgqnqhwhsb (htfohjlcgb ) View more	-	01 Jul 2019
				netilmicin (Coagulase negative Staphylococci)	pajxsvrztm(wxbzymaxvv) = ntsjzsuonb fgqnqhwhsb (htfohjlcgb ) View more

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