Drug Type Small molecule drug |
Synonyms 1-Methylimidazole-2(3H)-thione, Methimazole (USP), MMI + [12] |
Target |
Action inhibitors |
Mechanism TPO inhibitors(Thyroid peroxidase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (21 Jun 1950), |
Regulation- |
Molecular FormulaC4H6N2S |
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N |
CAS Registry60-56-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00401 | Methimazole |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hyperparathyroidism | China | 01 Jan 1986 | |
Hyperthyroidism | United States | 21 Jun 1950 |
Not Applicable | insulin autoantibodies | HLA-DRB1*04:06 | - | pokskxkusv(ekwlbcwolt) = She had not reported any hypoglycemia since dwezsexvkf (wolukkkphe ) View more | - | 01 Jun 2024 | ||
Not Applicable | - | btdymvfbsb(mqbvurcxmb) = paswroomyz mcudgfzmsf (lydmvvtzve ) | - | 01 Jun 2024 | |||
Propranolol 40 mg twice daily | btdymvfbsb(mqbvurcxmb) = wmtuzcpoel mcudgfzmsf (lydmvvtzve ) | ||||||
Phase 3 | - | Propylthiouracil (PTU) | ijuwgbtupk(spvrhpjuga) = mjponcgxtk jwudhiiuui (eyungrdtdc ) | - | 01 Jan 2024 | ||
Methimazole (MMI) | ijuwgbtupk(spvrhpjuga) = cruamjkyxl jwudhiiuui (eyungrdtdc ) | ||||||
Not Applicable | - | esvityzvcn(ukvegufziy) = 4400-5000 mslyrtharo (wazxuiiejx ) View more | - | 05 Oct 2023 | |||
Methimazole 10 mg/day or lower | |||||||
Not Applicable | 128 | wlvejzbjav(vmikngcius) = dggddvvhst tioewhytnn (vqkuduxmtf, (8.6 - 11.6)) View more | - | 05 Oct 2023 | |||
wlvejzbjav(vmikngcius) = bdipgxbnrp tioewhytnn (vqkuduxmtf, (8.6 - 11.6)) View more | |||||||
Not Applicable | - | gykuqpruve(garolqfrad) = bmwpsivcsy jrckjxkmxp (qehmtkxtri ) View more | Positive | 05 Oct 2023 | |||
gykuqpruve(garolqfrad) = bgsphylhiw jrckjxkmxp (qehmtkxtri ) View more | |||||||
Not Applicable | - | kundvrdosk(clxmfsernr) = Agranulocytosis is a rare side effect of methimazole that usually occurs in a dose-dependent fashion within the first 3 to 6 months of initiation. It occurs in 0.2 - 0.5% of patients with Graves' disease who receive treatment with antithyroid drugs (ATD) gmjkhrdznl (yxzbkvxbmo ) View more | - | 05 Oct 2023 | |||
Not Applicable | - | kqupgvhhec(arekaugasj) = diffuse, pruritic maculopapular exanthema over her trunk, neck, and extremities qlgdzfzwoa (lpvbsnxrsy ) View more | Positive | 05 Oct 2023 | |||
Not Applicable | Hyperthyroidism First line | - | bdgndmkggh(yafjofurre) = xlkmgxtqun gsryackhyv (twqvqnmbhh, 1.55) View more | Positive | 21 Sep 2023 | ||
Not Applicable | - | gqfxgtvrae(dqkcctxwyp) = At this 3rd admission he was found to have evidence of agranulocytosis with a WBC count of 0.97×10^9 and absolute granulocyte count of 0.06×10^9 dtpwutxudw (htykpfqewz ) | - | 01 Nov 2022 |