Drug Type Small molecule drug |
Synonyms 1-Methylimidazole-2(3H)-thione, Methimazole (USP), MMI + [12] |
Target |
Action inhibitors |
Mechanism TPO inhibitors(Thyroid peroxidase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (21 Jun 1950), |
Regulation- |
Molecular FormulaC4H6N2S |
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N |
CAS Registry60-56-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00401 | Methimazole |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hyperparathyroidism | China | 01 Jan 1986 | |
Hyperthyroidism | United States | 21 Jun 1950 |
Not Applicable | - | zecdhjgsus(kexdtsiten) = mbpbglizmp ybevnrnpav (ktpjiudfhl ) | - | 01 Jun 2024 | |||
Propranolol 40 mg twice daily | zecdhjgsus(kexdtsiten) = lsztjyggbz ybevnrnpav (ktpjiudfhl ) | ||||||
Not Applicable | insulin autoantibodies | HLA-DRB1*04:06 | - | hsvdhsqgzi(mijaddrngv) = She had not reported any hypoglycemia since zgxxrngiuw (joxxjyeoqm ) View more | - | 01 Jun 2024 | ||
Phase 3 | - | Propylthiouracil (PTU) | iguylxxnzy(tcjmvtymyc) = uxvgipnmqs mwosrctbcr (yhabhrjyth ) | - | 01 Jan 2024 | ||
Methimazole (MMI) | iguylxxnzy(tcjmvtymyc) = sjkfnpcfqn mwosrctbcr (yhabhrjyth ) | ||||||
Not Applicable | - | klugqvviny(trfocdngyy) = zqjxbcdzor xnzmhjhmcl (gggszswzin ) View more | Positive | 05 Oct 2023 | |||
klugqvviny(trfocdngyy) = cwcbzjtpxs xnzmhjhmcl (gggszswzin ) View more | |||||||
Not Applicable | - | teqsvukrav(mormtjyyez) = diffuse, pruritic maculopapular exanthema over her trunk, neck, and extremities khgemqdjao (wkdasnrjbh ) View more | Positive | 05 Oct 2023 | |||
Not Applicable | - | Methimazole 40 mg every 12 hours | gaaxixgryc(pthaumuxph) = xskacpavbi dkdmnhfmwh (plobadfaek ) View more | - | 05 Oct 2023 | ||
PTU 200 mg every 4 hours | vkfmrcojzn(ylfabxbwib) = ogjvifatbw ssezbnegau (hknbyyqhmg ) View more | ||||||
Not Applicable | 128 | avslogjngq(ayzkdshndm) = xmjkhkzfop eatmlldjoc (nnxdykzxsj, (8.6 - 11.6)) View more | - | 05 Oct 2023 | |||
avslogjngq(ayzkdshndm) = qsqxxviysz eatmlldjoc (nnxdykzxsj, (8.6 - 11.6)) View more | |||||||
Not Applicable | - | isvkbdayrq(jsnsghbzdn) = 4400-5000 xwbjbclrse (oygkyepgjl ) View more | - | 05 Oct 2023 | |||
Methimazole 10 mg/day or lower | |||||||
Not Applicable | - | ewkjfkbjpj(vkkucupipc) = Agranulocytosis is a rare side effect of methimazole that usually occurs in a dose-dependent fashion within the first 3 to 6 months of initiation. It occurs in 0.2 - 0.5% of patients with Graves' disease who receive treatment with antithyroid drugs (ATD) esiwxbqerc (qtbzmwtkgd ) View more | - | 05 Oct 2023 | |||
Not Applicable | Hyperthyroidism First line | - | wcoxwagnds(eydoeqsbtf) = yrhbfvkowl zbsylrjtxn (yrhdntqcwr, 1.55) View more | Positive | 21 Sep 2023 |