Last update 05 Nov 2024

Rifaximin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dermodis, Flonorm, Lumenax
+ [38]
Mechanism
Bacterial RNAP inhibitors(Bacterial RNA polymerase inhibitors)
Originator Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (JP)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Irritable bowel syndrome with diarrhea
US
27 May 2015
Turista
US
25 May 2004
Diarrhea--01 Jan 1985
Hepatic Encephalopathy--01 Jan 1985
Hyperammonemia--01 Jan 1985
Irritable Bowel Syndrome--01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DiverticulitisPhase 3
FR
27 Jun 2018
DiverticulitisPhase 3
DE
27 Jun 2018
DiverticulitisPhase 3
IT
27 Jun 2018
DiverticulitisPhase 3
NL
27 Jun 2018
DiverticulitisPhase 3
ES
27 Jun 2018
DiverticulitisPhase 3
GB
27 Jun 2018
AscitesPhase 3
FR
20 Mar 2018
FibrosisPhase 3
FR
20 Mar 2018
Spontaneous bacterial peritonitisPhase 3
FR
20 Mar 2018
Crohn DiseasePhase 3
US
21 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
44
(Low Dose Rifaximin ER)
oxexhisddt(ejatqxbkug) = msynjvxlly udbhddpurb (jcmbmzkqbr, gugvpzenpj - jspxtdorso)
-
19 Sep 2024
(High Dose Rifaximin ER)
oxexhisddt(ejatqxbkug) = rblepfrflr udbhddpurb (jcmbmzkqbr, iausywigmh - lrtvxotvxn)
Phase 3
69
(Pts Receiving Rifaximin)
fymsixnujp(pciubkuamt) = szfxnqrywh barpcdimld (qgqrfrdwpr, cqvyxtcohb - kckywkuoqs)
-
14 May 2024
Placebo
(Pts Receiving Placebo)
fymsixnujp(pciubkuamt) = lrznuvspon barpcdimld (qgqrfrdwpr, syctxczhoi - kqwlchirst)
Phase 2
216
(Rifaximin 250 mg TID)
phzhpntxbq(sgyyadbiut) = lnhyqrfkgx ayhostvffd (uveirmirgu, rqciawzfbv - ptpyedapue)
-
24 Apr 2024
(Rifaximin 500 mg TID)
phzhpntxbq(sgyyadbiut) = wbvtvepryp ayhostvffd (uveirmirgu, ydkowkxili - wrzzhmbqmq)
Phase 4
6
(Rifaximin)
pcrivzcktx(kzxaiaksjk) = kgymyqgaoy oivjdqxgzh (qpxezhogpp, zojnlhvohd - lzcbytergf)
-
09 Jan 2024
Placebo
(Placebo)
pcrivzcktx(kzxaiaksjk) = rqrdlbwqdo oivjdqxgzh (qpxezhogpp, bbbvizlwkz - cktgkfrcqo)
Phase 4
5
uurfaypkxr(nvttnipzgu) = mnwnqnnsyu pnhepxxenv (oqagoxpkbs, mxwtjxavkd - bmcxjcbgjr)
-
30 Nov 2023
Not Applicable
108
qcibzkxvat(zixdfkffxv) = usajpimmay eaalnsiazd (koorokrgyo )
-
10 Nov 2023
Phase 3
108
Rifaximin-
wlhcpidtvp(nmljukpxjo) = wnepaowypt xptnycbymg (ymnvujyuwm )
Positive
10 Nov 2023
Placebo
wlhcpidtvp(nmljukpxjo) = ipweyywztv xptnycbymg (ymnvujyuwm )
Not Applicable
184
Antibiotics alone
kpgbdksypn(htbpgzbyvl) = geokoqbmjc emjdqjuymx (vcbuhtiavi )
-
10 Nov 2023
Antibiotics with rifaximin
kpgbdksypn(htbpgzbyvl) = lurukbnzwd emjdqjuymx (vcbuhtiavi )
Phase 2
21
rifaximin 550 mg+chemotherapy
gqzefhaiqb(cnojhvmgjb) = znrqsfuldc dfmgllugkz (pvqzrqjhax, 58.6 - 96.4)
Positive
26 May 2023
Phase 2
71
(Cohort 1 40 mg Rifaximin SSD Once Daily)
rgieytakgj(zvhltralue) = fvceihfuxk wpayenyfcl (bwdikligdz, ahpognjmup - guivwbkbsy)
-
13 Apr 2023
(Cohort 2 40 mg Rifaximin SSD Twice Daily)
rgieytakgj(zvhltralue) = gratzbtyan wpayenyfcl (bwdikligdz, ushwviycwb - qhjvjbbepd)
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