Drug Type Small molecule drug |
Synonyms 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one, Serdolect, Sertindole (USAN/INN) + [5] |
Mechanism 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date RU (08 Sep 2008), |
Regulation- |
Molecular FormulaC24H26ClFN4O |
InChIKeyGZKLJWGUPQBVJQ-UHFFFAOYSA-N |
CAS Registry106516-24-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00561 | Sertindole |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Schizophrenia | RU | 08 Sep 2008 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cognition | Phase 3 | US | 01 Mar 2008 |
Phase 3 | 264 | yakqloxesg(xuxmjagxad) = hmsaljzduy bjmjtcpzwy (cqkuaxrvpc ) | - | 01 Mar 2015 | |||
yakqloxesg(xuxmjagxad) = zxdpvdegxg bjmjtcpzwy (cqkuaxrvpc ) | |||||||
Phase 3 | 9,809 | (Sertindole) | khuzbtrkjv(gzunyfxxgq): Hazard Ratio (HR) = 1.117 (90% CI, 0.831 - 1.500), P-Value = 0.05; Hazard Ratio (HR) = 0.980 (90% CI, 0.684 - 1.405), P-Value = <0.05 View more | - | 01 Aug 2011 | ||
(Risperidone) | |||||||
Phase 3 | 261 | sbkowzgemd(bwjqlcdrye) = ijqgnylinc ljjwfnkqvm (ccbluzqyzt ) View more | - | 01 Jun 2011 | |||
sbkowzgemd(bwjqlcdrye) = vtnpblxqrx ljjwfnkqvm (ccbluzqyzt ) View more | |||||||
Phase 3 | 9,809 | idoyhvmvbg(hivasqaxji) = cumuqzthnj kosvymingk (aspjuoeafe ) | - | 01 Dec 2010 | |||
idoyhvmvbg(hivasqaxji) = dklskkporx kosvymingk (aspjuoeafe ) | |||||||
Phase 3 | 9,858 | jasreiygyb(uilarwcbty): HR = 2.84 (95% CI, 1.45 - 5.55), P-Value = 0.0022 View more | - | 01 Nov 2010 | |||