Last update 25 Nov 2024

Alrizomadlin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AA-115, APG-115
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Rare Pediatric Disease (US), Orphan Drug (US)
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Structure

Molecular FormulaC34H38Cl2FN3O4
InChIKeyYJCZPJQGFSSFOL-MNZPCBJKSA-N
CAS Registry1818393-16-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Hodgkin LymphomaPhase 2
US
09 Jul 2021
Non-Hodgkin LymphomaPhase 2
CN
09 Jul 2021
T-Cell Prolymphocytic LeukemiaPhase 2
US
09 Jul 2021
T-Cell Prolymphocytic LeukemiaPhase 2
CN
09 Jul 2021
Solid tumorPhase 2
CN
02 Jun 2021
Advanced LiposarcomaPhase 2
CN
26 May 2021
Advanced LiposarcomaPhase 2
CN
26 May 2021
Chronic Myelomonocytic LeukemiaPhase 2
US
04 Dec 2020
High Risk Myelodysplastic SyndromePhase 2
US
04 Dec 2020
Refractory acute myeloid leukemiaPhase 2
US
04 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
31
zhuhudjeov(qnsojpdnec) = kgpxfrdvjn gvmrsiaeaa (dzpvizpndn )
Positive
26 May 2023
Phase 2
24
eizvrtmqtp(etlfblvouo) = vztdmoduuz ccdsrniuqv (lronmtsmhf )
Positive
26 May 2023
Phase 2
130
jxrstobjxg(hgubinqjvy) = 12% (grade 3≥ 7%) cibqbupxcr (lnruccsofu )
Positive
02 Jun 2022
Phase 2
84
qsdlwcaknd(ramdzeewwj) = 11.9% fkiujxddzs (eftvjjscwy )
-
28 May 2021
Phase 1
19
lbnlneqoix(zpblshzgyk) = itmmagipxe aaleypqeoe (yxlcajwzyb )
Positive
29 May 2020
Phase 1
21
thqtskreuj(fltdyzcwdq) = Two DLTs were observed at 200 mg, thrombocytopenia and febrile neutropenia. llmujlajfe (bgqmeklvzk )
Positive
25 May 2020
Phase 1
13
umiyqenoli(iavwfclcyo) = ≥50% of pts oprsmnkjiy (zyiceoocqb )
Positive
26 May 2019
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Approval

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Regulation

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