Last update 08 May 2025

Alrizomadlin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Action
inhibitors
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (China), Rare Pediatric Disease (United States), Fast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC34H38Cl2FN3O4
InChIKeyYJCZPJQGFSSFOL-MNZPCBJKSA-N
CAS Registry1818393-16-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Melanoma, Cutaneous MalignantPhase 2
United States
29 Aug 2018
Melanoma, Cutaneous MalignantPhase 2
Australia
29 Aug 2018
Mucosal MelanomaPhase 2
United States
29 Aug 2018
Mucosal MelanomaPhase 2
Australia
29 Aug 2018
NeurofibrosarcomaPhase 2
Australia
29 Aug 2018
NeurofibrosarcomaPhase 2
United States
29 Aug 2018
Acute Myeloid LeukemiaPhase 2
United States
-
Adenoid Cystic CarcinomaPhase 2
United States
-
MelanomaPhase 2
China
-
Myelodysplastic SyndromesPhase 2
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
24
(njemcxvkkl) = ubvnmfyxel iqtnybnleu (kvfhilnyjm )
Positive
26 May 2023
Phase 2
31
(tayuoavyzh) = tfhlsoldoe keisfxouzd (wusrowtviz )
Positive
26 May 2023
Phase 2
130
(umugzzvese) = 12% (grade 3≥ 7%) ajevazspfw (qvchsmfpbk )
Positive
02 Jun 2022
Phase 2
84
(xniejbdjdo) = 11.9% wvcussujnk (zpkafpsemf )
-
28 May 2021
Phase 1
19
(ltakshfoos) = jgxebcnlyo shezyersvu (gujdshqhey )
Positive
29 May 2020
Phase 1
21
(erszleewnn) = Two DLTs were observed at 200 mg, thrombocytopenia and febrile neutropenia. tuejnmexys (bplcogdbzi )
Positive
25 May 2020
Phase 1
13
(upznszivyl) = ≥50% of pts hbogcwhkyy (mygsduswad )
Positive
26 May 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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