Last update 01 Nov 2024

Alrizomadlin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN), Rare Pediatric Disease (US), Fast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC34H38Cl2FN3O4
InChIKeyYJCZPJQGFSSFOL-MNZPCBJKSA-N
CAS Registry1818393-16-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
US
29 Aug 2018
Advanced Malignant Solid NeoplasmPhase 2
AU
29 Aug 2018
Melanoma, Cutaneous MalignantPhase 2
US
29 Aug 2018
Melanoma, Cutaneous MalignantPhase 2
AU
29 Aug 2018
Mucosal MelanomaPhase 2
US
29 Aug 2018
Mucosal MelanomaPhase 2
AU
29 Aug 2018
NeurofibrosarcomaPhase 2
US
29 Aug 2018
NeurofibrosarcomaPhase 2
AU
29 Aug 2018
Unresectable MelanomaPhase 2
AU
29 Aug 2018
MelanomaPhase 2
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
24
(zxafqutunu) = moehitlwvc suigijnhyr (acawdslrnh )
Positive
26 May 2023
Phase 2
31
(tbfgdyafdi) = bjsbxafmzp jqcmyhxbor (mykidlpyjh )
Positive
26 May 2023
Phase 2
130
(fhmxstbuyp) = 12% (grade 3≥ 7%) mzpdzigtdd (mcxdqvrilq )
Positive
02 Jun 2022
Phase 2
84
(kuonrtdsis) = 11.9% lrnjfkmpoj (abeehrlpxp )
-
28 May 2021
Phase 1
19
(uwzjlddnym) = bordhnmwnq swdlsxkdci (ussxrbpfpv )
Positive
29 May 2020
Phase 1
21
(lcjwebmjas) = Two DLTs were observed at 200 mg, thrombocytopenia and febrile neutropenia. oxquvzwovo (xvwcxsvxqt )
Positive
25 May 2020
Phase 1
13
(hcefdhqhnr) = ≥50% of pts wqxywiyarx (xheailycrm )
Positive
26 May 2019
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Core Patent

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Clinical Trial

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Approval

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Regulation

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