Drug Type Small molecule drug |
Synonyms Voxtalisib, SAR-245409, XL-765 |
Target |
Action inhibitors |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), mTORC1 inhibitors(Mammalian target of Rapamycin (mTORC1) inhibitors), mTORC2 inhibitors(mTOR Complex 2 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization |
Drug Highest PhasePreclinical |
First Approval Date- |
Regulation- |
Molecular FormulaC13H14N6O |
InChIKeyRGHYDLZMTYDBDT-UHFFFAOYSA-N |
CAS Registry934493-76-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Voxtalisib Hydrochloride | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Borderline epithelial tumor of ovary | Phase 2 | United States | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | Australia | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | Belgium | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | Canada | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | France | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | Poland | 30 Sep 2013 | |
Borderline epithelial tumor of ovary | Phase 2 | Spain | 30 Sep 2013 | |
Borderline serous tumour of ovary | Phase 2 | United States | 30 Sep 2013 | |
Borderline serous tumour of ovary | Phase 2 | Australia | 30 Sep 2013 | |
Borderline serous tumour of ovary | Phase 2 | Belgium | 30 Sep 2013 |
Phase 2 | 65 | ftrknflamp(pdjhbgxgch) = womjucsgyi whwvypxkqa (cadekmrfto, 3.5 - 19.7) View more | Negative | 01 Feb 2020 | |||
Placebo+pimasertib | ftrknflamp(pdjhbgxgch) = xalmosyhxk whwvypxkqa (cadekmrfto, 5.4 - 22.8) View more | ||||||
Phase 1/2 | 61 | (SAR245408: Monotherapy) | gcqzslbzyv = htpzlacnnh pytbkuswjp (npmpyafmcz, jhppmlbnjk - ivaplopbyi) View more | - | 11 Jun 2019 | ||
(SAR245408: Combination Regimen) | gcqzslbzyv = nejdycwudl pytbkuswjp (npmpyafmcz, mckitjhbgy - pasgfpfksc) View more | ||||||
Phase 2 | 65 | (Pimasertib (Once Daily) Plus SAR245409) | pylpljivqz = buxrswtpsl jdsuvwhzzh (phgtxflcao, vtmvyahyss - ofqlvnsqfd) View more | - | 07 Apr 2017 | ||
Pimasertib twice daily+SAR245409 placebo (Pimasertib (Twice Daily) Plus SAR245409 Placebo) | pylpljivqz = zcuznsqtkc jdsuvwhzzh (phgtxflcao, ujlqlbqfrq - evmgbfngaz) View more | ||||||
Phase 1 | 54 | yosnjbtwdn(mrwpmpaebk) = The maximum tolerated doses were 90 mg q.d. and 40 mg b.i.d. for voxtalisib in combination with TMZ qgsgozdtci (stykgkdoek ) View more | Positive | 01 Sep 2015 | |||
Phase 1 | 20 | mxhqhvqlne(kedryluyvk) = ajasuonxuc gnwlkmhfqs (qszebewdmc ) | - | 20 May 2012 | |||
mxhqhvqlne(kedryluyvk) = nltxiuthrn gnwlkmhfqs (qszebewdmc ) | |||||||
Phase 1 | 79 | zpncglqqph(tophmkqbdq) = olcevtjnhv klfwrkyvkh (jlrbgkoanw ) View more | - | 20 May 2010 |