Delving into the Latest Updates on COR123625 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

MIF

Action

inhibitors

Mechanism

MIF inhibitors(Macrophage migration inhibitory factor inhibitors)

Therapeutic Areas

Other Diseases

Active Indication

Inflammation

Inactive Indication-

Originator Organization

Papua New Guinea Institute of Medical Research

Institut Pasteur

Monash University

+ [2]

Active Organization

Institut Pasteur

Cabrini University

Monash University

+ [2]

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Author: Mueller, Ivo ; Aitken, Elizabeth H ; Elgass, Kirstin ; Traore, Daouda A K ; Baiwog, Francesca S ; Creed, Sarah J ; Lee, Jacinta P W ; Skene, Colin ; Morand, Eric F ; Wilce, Matthew C J ; Deen, Nadia S ; Lang, Tali ; Pinar, Anita A ; Fan, Huapeng ; Harris, James ; Mansell, Ashley ; Stanisic, Danielle ; Tate, Michelle D

AbstractMacrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show that inhibition of MIF regulates the release of IL-1α, IL-1β, and IL-18, not by affecting transcription or translation of these cytokines, but via activation of the NLRP3 inflammasome. MIF is required for the interaction between NLRP3 and the intermediate filament protein vimentin, which is critical for NLRP3 activation. Further, we demonstrate that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation independent of its role as a cytokine. These data advance our understanding of how MIF regulates inflammation and identify it as a factor critical for NLRP3 inflammasome activation.

100 Deals associated with COR123625

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Inflammation	Preclinical	Australia	Cabrini University	08 Jun 2018
Inflammation	Preclinical	France	Institut Pasteur	08 Jun 2018
Inflammation	Preclinical	Australia	Hudson Institute of Medical Research	08 Jun 2018
Inflammation	Preclinical	Papua New Guinea	Papua New Guinea Institute of Medical Research	08 Jun 2018
Inflammation	Preclinical	Australia	Monash University	08 Jun 2018