Last update 09 Nov 2024
SAR444200
Last update 09 Nov 2024
Overview
Basic Info
Drug Type Nanobody |
Synonyms SAR 444200, SAR-444200, SAR444200 |
Target |
Mechanism GPC3 inhibitors(Glypican-3 inhibitors), TCR antagonists(T-cell receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
Regulation- |
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Related
2
Clinical Trials associated with SAR444200A Phase 1/2 Open-label, First-in-human, Dose Escalation and Expansion Study for the Evaluation of Safety, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of SAR444200-based Regimen in Participants With Advanced Solid Tumors.
一项在晚期实体瘤患者中评估 SAR444200 给药方案的安全性、药代动力学、药效动力学和抗肿瘤活性的Ⅰ/Ⅱ期、开放性、首次人体、剂量递增和扩展研究。
[Translation] A Phase I/II, open-label, first-in-human, dose-escalation and expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of a dosing regimen of SAR444200 in patients with advanced solid tumors.
100 Clinical Results associated with SAR444200
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100 Translational Medicine associated with SAR444200
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100 Patents (Medical) associated with SAR444200
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100 Deals associated with SAR444200
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Malignant Solid Neoplasm | Phase 2 | US | 20 Sep 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | CN | 20 Sep 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | CA | 20 Sep 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | SG | 20 Sep 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | KR | 20 Sep 2022 | |
| GPC3 Positive Neoplasms | IND Approval | CN | 09 Jul 2023 | |
| GPC3 Positive Neoplasms | IND Approval | CN | 09 Jul 2023 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 1/2 | Advanced Malignant Solid Neoplasm interleukin-6 | interferon gamma | alpha-fatal protein (AFP) | 24 | gpeqttvczi(zmoacvanya) = 2 events with hospitalization prolongation for a Grade 1 and 2 cytokine release syndrome [CRS] that recovered completely without and with Tocilizumab, respectively, 1 event with pneumonitis Grade 3 sqpqydbdpi (mbonqvoswp ) View more | Positive | 24 May 2024 | ||
SAR444200 1 mg |
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