To evaluate the efficacy of 38 percent Silver diamine fluoride along with atraumatic restorative technique in arresting caries among secondary school children in rural Telangana: A Randomized controlled trial - NIL

Start Date11 Nov 2024

Sponsor / Collaborator-

CTRI/2024/08/072965 / Not yet recruitingPhase 3

Comparative Evaluation of Selective Caries Removal Techniques Followed by SDF Application In Primary Molars - An In Vivo Study - NIL

Start Date02 Sep 2024

Sponsor / Collaborator-

CTRI/2024/08/072862 / Not yet recruitingPhase 4IIT

To assess the effectiveness of silver diamine fluoride application with delayed glass ionomer cement restoration in dentinal caries of differently abled children An in-vivo study - Nil

Start Date02 Sep 2024

Sponsor / Collaborator-

100 Clinical Results associated with Silver Diammine Fluoride

100 Translational Medicine associated with Silver Diammine Fluoride

100 Patents (Medical) associated with Silver Diammine Fluoride

732

Literatures (Medical) associated with Silver Diammine Fluoride

01 Dec 2024·JOURNAL OF DENTISTRY

Antibacterial and mineralising properties of copper tetraamine fluoride on dentine caries: A laboratory study

Article

Author: Yin, Iris Xiaoxue ; Xu, Veena Wenqing ; Niu, John Yun ; Yu, Ollie Yiru ; Nizami, Mohammed Zahedul Islam ; Chu, Chun Hung

OBJECTIVE:

To investigate the antibacterial, mineralising, and discolouring properties of copper tetraamine fluoride (CTF) on artificial dentine caries.

METHOD:

Demineralised human dentine blocks were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before they were subjected to cariogenic challenge with Streptococcus mutans biofilm. The morphology, viability, and growth kinetics of the biofilm were assessed by scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting. The lesion depths, mineral loss, chemical structure, and crystal characteristics were measured using micro-computed tomography, Fourier transform infrared (FTIR), and X-ray diffraction (XRD). The discolouring property on demineralised dentine was assessed by spectrophotometry. One-way analysis of variance with the Bonferroni post hoc test was performed to assess and compare the data.

RESULTS:

SEM revealed confluent bacterial growth covering the surface of dentine treated with Water but not CTF and SDF. CLSM showed the dead-to-live ratio of the biofilm treated with CTF, SDF and Water were 0.7 ± 0.1, 0.8 ± 0.1 and 0.5 ± 0.1 (p < 0.001, CTF, SDF>Water). The Log₁₀ CFU values of the biofilm treated with CTF, SDF and Water were 7.8 ± 0.1, 7.8 ± 0.1 and 8.1 ± 0.2 (p < 0.001, CTF, SDF-3) of dentine treated with CTF, SDF and Water were 0.19 ± 0.04, 0.18 ± 0.04 and 0.30 ± 0.04 (p < 0.001, CTF, SDF

CONCLUSION:

CTF inhibited Streptococcus mutans. It mineralised but not discoloured artificial dentine caries.

CLINICAL SIGNIFICANCE:

If CTF is successfully translated into clinical application, it may be a non-discolouring anti-caries agent for clinicians to arrest dentine caries.

01 Dec 2024·JOURNAL OF DENTISTRY

The anti-caries effects of copper tetraamine fluoride on enamel: An in vitro study

Article

Author: Yin, Iris Xiaoxue ; Xu, Veena Wenqing ; Niu, John Yun ; Yu, Ollie Yiru ; Nizami, Mohammed Zahedul Islam ; Chu, Chun Hung

OBJECTIVE:

To investigate the antibacterial, remineralising, and discolouring effects of copper tetraamine fluoride (CTF) on artificial enamel caries.

METHOD:

Human enamel blocks with artificial caries were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before being challenged with Streptococcus mutans. The morphology, viability, and growth kinetics of biofilm were evaluated using scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting. The lesion depths, mineral loss, micro-hardness, and crystal characteristics were assessed using micro-computed tomography, Knoop Hardness Tester, and X-ray diffraction (XRD), respectively. The discolouring property was assessed by spectrophotometry.

RESULTS:

SEM showed that bacteria completely covered the enamel surface treated with water, but not the enamel surface treated with CTF and SDF. CLSM showed dead-to-live ratio of biofilm treated with CTF, SDF and water were 0.8 ± 0.1, 0.9 ± 0.2 and 0.5 ± 0.1 (p < 0.001, CTF, SDF>Water). Log₁₀ CFU values of biofilm treated with CTF, SDF and water were 7.7 ± 0.2, 7.7 ± 0.1 and 8.1 ± 0.1 (p < 0.001, CTF, SDF-3) of the CTF, SDF and water groups were 0.4 ± 0.1, 0.4 ± 0.2 and 1.0 ± 0.2 (p < 0.001, CTF, SDFWater). XRD revealed well-crystallised hydroxyapatite in enamel treated with CTF and SDF, but not water. Spectrophotometry showed ΔE values of the CTF, SDF and water groups were 5 ± 3, 54 ± 6 and 6 ± 2 (p < 0.001, CTF, water

CONCLUSION:

CTF inhibited Streptococcus mutans biofilm and remineralised artificial enamel caries without discolouration.

CLINICAL SIGNIFICANCE:

If CTF is successfully translated into clinical use, it can be a simple agent for clinicians to arrest enamel caries.

01 Dec 2024·INTERNATIONAL DENTAL JOURNAL

Frontiers of Global Research Trend on Root Caries: A Bibliometric Analysis

Review

Author: Xu, Grace Yuchan ; Yin, Iris Xiaoxue ; Lung, Christie Ying Kei ; Zhao, Irene Shuping ; Chu, Chun Hung ; Lo, Edward Chin Man

OBJECTIVE:

This study aimed to examine the global research trend and frontiers in the field of root caries.

METHODS:

Two independent investigators searched the Web of Science Core Collection to include journal articles published on root caries from 1994 to 2023. They examined citation trends of the selected publications and performed bibliometric analysis using VOSviewer. Cooccurrence and cocitation analysis were used to calculate the burst strength of the most cited keywords and the most cited publications.

RESULTS:

This study included 1144 publications (1004 scientific research articles and 140 review articles) for bibliometric analysis. The number of publications from 2018 to 2023 was 404, accounting for 35% (404/1144) over the last 30 years. The annual citation count showed a gradual upward trend with a surge from 2018. The cooccurrence analysis classified the publications into four clusters which were in vitro studies, prevention, microbiology, and epidemiology. Cocitation analysis revealed silver diamine fluoride, systematic review, and randomized clinical trial were the three main keywords; and their citation burst strength (period) were 17.2 (2017-2023), 9.4 (2015-2023), and 6.9 (2018-2023), respectively. Noninvasive treatment of root caries (narrative review), aetiology of root caries (narrative review), and use of silver diamine fluoride in arresting root caries (clinical trial) were the topics (publication type) of the three most cited publications; and their burst strength (period) were 8.9 (2017-2020), 5.9 (2017-2021), and 4.7 (2015-2018), respectively.

CONCLUSION:

This study highlights the recent growing research interest in root caries, particularly on its microbiology, prevention, and the use of silver diamine fluoride.

News (Medical) associated with Silver Diammine Fluoride

03 Jan 2024

·www.businesswire.com

MouthWatch Marks 2023 a Year of Virtual-First Care Innovation and Leading Intraoral Photography Growth

METUCHEN, N.J.--( BUSINESS WIRE )--MouthWatch, LLC, an industry leader in teledentistry solutions and dental intraoral cameras , is marking 2023 as a year defined by its commitment to continuous innovation, development of new technology solutions, and helping dental professionals increase access to care, improve oral health, and deliver excellence in patient experience. “As we reflect on 2023 and look ahead to 2024 and beyond, we are so proud of what we have accomplished, grateful for the recognition we have received, and excited about the growing role MouthWatch solutions play in addressing the needs of today’s patients, healthcare professionals, and organizations focused on patient health,” said Brant Herman, Founder and Chief Executive Officer of MouthWatch and Dentistry One . 2023 was an exciting year for MouthWatch, as it continued to bring new and exciting solutions to the marketplace: Virtual Care Innovation: MouthWatch launched Dentistry.One; a virtual-first dental care network built to break down barriers to oral health care, address the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and overall health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. Congressional Briefing : Mr. Herman joined other distinguished leaders in dental innovation at a Congressional Briefing in Washington, D.C., hosted by the Dental Trade Alliance, to share insights and experience about how teledentistry and artificial intelligence can improve both access to dental care and patient outcomes. Founder Recognition: Mr. Herman was named among NJBIZ Magazine’s “2023 People to Watch in Healthcare.” He was also named by the American Mobile and Teledentistry Alliance as one of the "Top 50 Teledentistry Leaders to Know in 2023," along with three other company Directors. Leadership Team Growth: New leadership roles were created to ensure continued growth and success of MouthWatch and Dentistry One: Carolyn Brown, DDS: Dr. Brown assumed the role of Chief Dental Officer at Dentistry One. She first joined MouthWatch in 2022 as Chief Health Innovation Officer, a position she continues to hold. Dr. Brown is nationally recognized for her focus on helping individuals and organizations achieve growth, improve health outcomes, leverage digital innovation, and bridge the gap across the medical-dental divide. She was instrumental in helping to launch Dentistry.One. Dr. Brown’s training at Dartmouth during the early days of value-based care and ACO formation is invaluable in the understanding of big data, diagnostic codes, healthtech, and risk-based partnerships. Previously, Dr. Brown has held academic positions at two dental schools, with over $20 million in research-related grant funding, and was amongst the first in the country to explore new models of dental care, including mobile and teledentistry. Sharity Ludwig, EPDH, MS: Ms. Ludwig joined Dentistry One as Senior Director of Clinical Operations. In this pivotal role, she oversees the development and implementation of innovative clinical strategies and processes for ensuring a seamless Dentistry One Provider-Patient experience. Prior to joining Dentistry One, Ms. Ludwig worked for 12+ years in various roles at DentaQuest, the largest Medicaid dental benefits administrator in the US. Her primary role was responsible for collaborating with clinical providers and operations management to develop and implement non-traditional services and care models across more than 70 practices and 200 providers. She played a key role in developing high-value clinical business opportunities and defining strategic and tactical objectives to oversee community-based care coupled with integrated care models for physical, behavioral, and oral health systems. Ms. Ludwig, in addition to dental care administration, treated at-risk patient populations as a clinical dental hygienist in both a federally qualified health center and private practice. Her background also includes coordinating dental services among various public and private dentistry stakeholders for a public health department and serving as project director for a Phase 3 randomized clinical trial of silver diamine fluoride. Susan Vassallo: Ms. Vassallo was promoted to Director of Marketing for MouthWatch and Dentistry One. In this role, she is responsible for driving visibility for the company’s products, services, and solutions to help ensure their sustained success. Ms. Vassallo brings over two decades of leadership experience in marketing communications and brand management to the company. Prior to joining MouthWatch and Dentistry One, her work in creating and deploying marketing communications strategies and initiatives contributed to growing a $1.5 billion national healthcare distributor into a multi-billion-dollar global Fortune 500 health solutions company serving dental and medical practitioners. Ms. Vassallo is passionate about raising awareness for important health topics and uncovering opportunities to increase access to care. Product Awards: The MouthWatch Intraoral Camera continued its winning streak by taking a 2023 Dentaltown Magazine Townie Choice Award in its category for the fourth consecutive year. In addition, the dental industry online forum and community, Nifty Thrifty Dentists, awarded the MouthWatch Intraoral Camera with a best product award based on its value and performance. The company’s newest product, The MouthWatch Plus+ HD Intraoral Camera was recognized with three separate awards by Dentistry Today Magazine : “Top 50 Technology Products,” “Readers’ Choice Top 100 Products,” and “Top Innovative Products.” “The success we achieved during 2023 was possible because of the outstanding expertise of the MouthWatch and Dentistry One team and the deep commitment we share to improve oral health and help our customers achieve their goals,” said Mr. Herman. “We look forward to taking on 2024 and beyond with the same vigor and enthusiasm we experienced this past year.” About MouthWatch, LLC MouthWatch, LLC, is a leader in developing digital technology solutions that drive success for dental professionals, improve oral health care, and enhance the overall patient experience. Headquartered in Metuchen, New Jersey, MouthWatch is widely known for its intraoral cameras that help engage patients in treatment planning through high-quality, affordable imaging technology, and its TeleDent software that provides practices and organizations with a teledentistry option to engage patients with providers remotely. MouthWatch launched Dentistry.One, a virtual-first care network that addresses the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and total health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. MouthWatch hardware and software are in use at over 40,000 practices, over 40 leading Dental Service Organizations (DSOs), and over 100 dental and hygiene schools. The company has been recognized three times in the Inc. 5000. For more information, visit mouthwatch.com . or dentistry.one .

Executive ChangePhase 3

10 Feb 2023

·www.sciencedaily.com

School dental program prevents 80 percent of cavities with one-time, non-invasive treatment

In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. The findings, published in JAMA Network Open, offer an efficient and cost-effective approach to improving children's oral health through school-based care. Dental cavities are the most common chronic disease in children, and kids from low-income families are twice as likely to have cavities as those from higher-income families. Without proper and timely intervention, cavities can lead to severe infections, reduce children's quality of life, and are associated with lower student academic performance and school attendance. But getting kids to a dentist for the recommended twice-yearly visits can be challenging, especially when parents need to take time off of work. To reduce the barriers to seeing a dentist, some basic dental services can be offered in schools, especially those serving children from low-income families. For example, the Centers for Disease Control and Prevention recommends and funds school sealant programs. In 2017, NYU College of Dentistry researchers received funding from the Patient-Centered Outcomes Research Institute (PCORI) to run the nation's largest school-based cavity prevention study, which they named CariedAway. CariedAway is a randomized trial comparing the effectiveness of two cavity-prevention techniques: a "simple" treatment using silver diamine fluoride (SDF) and fluoride varnish, and a "complex" treatment using traditional glass ionomer sealants and fluoride varnish. Both are non-invasive and applied to the surface of teeth to prevent and arrest cavities in children, but for the same time and cost, providers can treat more children with the simpler SDF therapy. The study included 2,998 children in kindergarten through third grade at 47 New York City schools. The schools -- which serve a racially diverse group of students, most of whom are from low-income families -- were randomized to receive either the simple or complex treatment. Upon visiting each school, the clinical research team -- which included a supervising dentist, dental hygienists, registered nurses, and assistants -- did baseline exams to measure any tooth decay, and then applied fluoride varnish and either sealants or SDF, depending on whether the school was assigned to receive the complex or simple treatment. The initial visits took place in 2019 and early 2020, and were paused when the COVID-19 pandemic temporarily closed New York City schools and halted all school-based care. Two years later, schools allowed the clinical research team to resume, and they returned to each school for follow-up visits. The researchers found that both the simple and complex treatments were successful: just one cavity prevention treatment prevented more than 80% of cavities (81% for SDF and 82% for sealants) and stopped half of cavities from progressing (56% for SDF and 46% for sealants). "Without prevention, dental cavities grow continuously if not treated. One CariedAway cavity prevention treatment, provided just before schools closed during the pandemic, was remarkably effective over the following two-year period," said Richard Niederman, DMD, professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway, and the study's senior author. "I know of no other dental preventive intervention that had this great a beneficial impact across the pandemic." While the limited availability of trained dental professionals can pose challenges for school sealant programs, as sealants are applied by a dentist or dental hygienist, SDF may be an attractive alternative, as it can also be applied by nurses -- a workforce already in place in many schools. "Our results support the use of SDF for cavity prevention in school-based oral health programs and offer an opportunity for expanding access to critical oral health care," said Ryan Richard Ruff, MPH, PhD, associate professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway and the study's first author. Tamarinda Barry-Godín, DDS, MPH, was a study co-author. This research was funded by the Patient-Centered Outcomes Research Institute (award PCS-1609-36824).

Clinical Result

100 Deals associated with Silver Diammine Fluoride

External Link

KEGG	Wiki	ATC	Drug Bank
D01502	-	A01AA	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Root Caries	JP	Toyo Pharmar Co. Ltd.	25 Sep 2009
Dental Caries	JP	Toyo Pharmar Co. Ltd.	24 Feb 2009
Dentin Sensitivity	JP	Toyo Pharmar Co. Ltd.	24 Feb 2009

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05761041 (Pubmed \| BMC Oral Health)	Phase 3	Dental Caries	165	silver diamine fluoride (38% SDF solution)	sfdqfrscgx(axipttajlr) = evacclrrer qnqgigbatl (hbhcogpitt ) View more	Positive	04 Oct 2023
				silver diamine fluoride (5% NaF varnish + MI)	sfdqfrscgx(axipttajlr) = cthvsitplq qnqgigbatl (hbhcogpitt ) View more
Pubmed \| Dent Med Probl	Not Applicable	Dental Caries	190	38% silver diamine fluoride (Atraumatic Restorative Treatment (ART))	miqqdqmctw(xmwrkionmy) = fbkntoekwj iwlnnlcpcp (oytxgutbpd )	Positive	29 Apr 2022
NCT04186663 (CTgov)	Phase 2	Dental Caries	59	Silver Diamine Fluoride	icdpxjtdct(nmecyxrrbf) = vfqrracdbj oupeyoabmi (lewlsrwyxd, ocuztgapwk - qvuszhghpk) View more	-	10 Mar 2022
NCT03186261 (CTgov)	Phase 3	Dental Caries	44	Nano silver fluoride solution (Nano Silver Fluoride Solution)	keujuelabd(hkbkxktiwn) = gemttozszk vzormuszrq (gstjnudjuc, vdpruywfzf - fykflaaqib) View more	-	16 Sep 2021
				Cavity Cleanser (Cavity Cleanser)	keujuelabd(hkbkxktiwn) = zqslwqkflu vzormuszrq (gstjnudjuc, afrwlmqiae - xixtepoakz) View more
NCT04184271 (CTgov)	Phase 2	Dental Caries	16	38% silver diamine fluoride	hjedreykxa(tdjxdhamag) = dqzilrkjkx dnvskrdbsj (uooywuazca, zqzxpkbthw - rxcoiqbqqr) View more	-	14 Aug 2020
NCT02536040 (CTgov)	Phase 3	Dental Caries	66	38% diammine silver fluoride (38% Diamine Silver Fluoride)	yamaztbvbw(pjzaelpcms) = dkiepuyeoe obokhcqsag (ovzaysawfj, flpmosqprg - bhdpbqevxg) View more	-	23 Jan 2020
				Water (Water)	yamaztbvbw(pjzaelpcms) = nasjphmigz obokhcqsag (ovzaysawfj, rckyoygzcr - wriqdjbwgm) View more
NCT02360124 (CTgov)	Phase 2/3	Root Caries	323	Water as placebo (Control)	xynrbhtfwx(nqoslqvani) = gotxqkybmt mdlcsujruv (qsrarrixyg, hnaszumved - zutwoyhaef) View more	-	19 May 2016
				silver diammine fluoride (Silver Diammine Fluoride)	xynrbhtfwx(nqoslqvani) = ycreizyfwm mdlcsujruv (qsrarrixyg, gfqymjhxer - qpddmghsfl) View more

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