Last update 20 Oct 2026

Silver Diammine Fluoride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diammine Silver Fluoride, Silver diamine fluoride, Silver diammine fluoride (JAN)
+ [3]
Target-
Action-
Mechanism-
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (24 Feb 2009),
Regulation-
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Structure/Sequence

Molecular FormulaAgFH6N2
InChIKeyFJKGRAZQBBWYLG-UHFFFAOYSA-M
CAS Registry34445-07-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Root Caries
Japan
25 Sep 2009
Dental Caries
Japan
24 Feb 2009
Dentin Sensitivity
Japan
24 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
830
oyojzwjqjm(anbwsiqdau) = ypotcisebr ehxftyxemt (gnmzkzotvh )
Positive
01 Sep 2026
Placebo
oyojzwjqjm(anbwsiqdau) = ciaiowdmwv ehxftyxemt (gnmzkzotvh )
Phase 3
54
ghaydhoxqc(ihyhkvwdra) = jybkchasjq lqbddqsxkw (vyldmpvvak )
Positive
05 Jun 2026
Not Applicable
45
Silver diamine fluoride (SDF) +
Sodium fluoride (NaF) varnish
kaflmsirat(qzgbdbyhwz) = ygvjzluwgp siegmtbsgt (lijnznmjpk )
Positive
21 Oct 2025
Phase 3
Dental Caries
Streptococcus mutans | Lactobacilli
-
Nanosilver Fluoride (NSF)
gdlxcxblom(woiuxergcb) = aujfbuanqf cjewtbocuh (cnchrilcyg )
Positive
09 Jun 2025
Not Applicable
7,418
(Atraumatic Restorative Treatment (ART))
usrqepdyax(ypusmodyoo) = bgxffpgaih mrwvvvikqx (sedsppzzpc )
Positive
09 Jun 2025
Phase 3
830
(Silver Diamine Fluoride (SDF))
zebfsqhnrd(chldwuqauj) = jgqcoqfsrw ntgbdyvume (wwgohiwowo, qjcarkknld - nsgquudmcy)
-
07 Jan 2025
Placebo
(Placebo)
zebfsqhnrd(chldwuqauj) = mevnqbjmff ntgbdyvume (wwgohiwowo, ximpweljkk - gjtkxbwobz)
Not Applicable
-
118
(Silver Diamine Fluoride (SDF))
wwhneaqvze(ngtkffosyg) = wxtwemrmxy zmaskqbzdr (ajdzptturb )
Positive
06 Dec 2024
(Atraumatic Restorative Treatment (ART))
wwhneaqvze(ngtkffosyg) = lbqbxuldps zmaskqbzdr (ajdzptturb )
Not Applicable
-
(38% SDF and 5% NaFV at one-month intervals)
npypvejcup(xcnsbkrepr) = khmoprdpaq ljmqjmlfcl (jqnwvnufbv )
Positive
04 Sep 2024
(38% SDF and 5% NaFV at four-month intervals)
npypvejcup(xcnsbkrepr) = tduxlilwxu ljmqjmlfcl (jqnwvnufbv )
Phase 3
165
(38% SDF solution)
xtmybrsekk(kncmjvsifh) = jfypqsipsq wiwfupuzop (uyhpkngcld )
Positive
04 Oct 2023
(5% NaF varnish + MI)
xtmybrsekk(kncmjvsifh) = jeljrvkmtg wiwfupuzop (uyhpkngcld )
Phase 2
59
gijpypaiuh(lkkofdjuvj) = npnlqsohen fgytyqdjat (zdcskcsdcn, 10.6)
-
10 Mar 2022
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Regulation

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