Last update 27 Mar 2025

CSL-112

Overview

Basic Info

Drug Type
Biological products
Synonyms
Apolipoprotein A-I, rHDL, APOA-1
+ [2]
Target
Action
stimulants
Mechanism
APOA1 stimulants(Apolipoprotein A-I stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Coronary SyndromePhase 3
United States
21 Mar 2018
Acute Coronary SyndromePhase 3
Japan
21 Mar 2018
Acute Coronary SyndromePhase 3
Argentina
21 Mar 2018
Acute Coronary SyndromePhase 3
Australia
21 Mar 2018
Acute Coronary SyndromePhase 3
Austria
21 Mar 2018
Acute Coronary SyndromePhase 3
Belgium
21 Mar 2018
Acute Coronary SyndromePhase 3
Brazil
21 Mar 2018
Acute Coronary SyndromePhase 3
Bulgaria
21 Mar 2018
Acute Coronary SyndromePhase 3
Canada
21 Mar 2018
Acute Coronary SyndromePhase 3
Chile
21 Mar 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
18,226
eespxxscuf = rebzqvntmr ysszpricsp (cwdkwuuxmw, qasjkykqja - kycuyvpdbh)
-
25 Mar 2025
Placebo
(Placebo)
eespxxscuf = asvupjvcvn ysszpricsp (cwdkwuuxmw, pxyhyujbnz - xuixwcqmgx)
Phase 3
-
CSL112 6g infusions
zuwfjrwrbc(tfnimhhuoo): RR = 0.81 (95% CI, 0.68 - 0.97), P-Value = 0.02
Positive
01 Nov 2024
Placebo infusions
Phase 3
Acute myocardial infarction
low cholesterol efflux - | apolipoprotein A1
-
tfbxriqghz(wrtzzwyntb) = npkffrezso hnpcwmvuop (qddrwqutsj )
Negative
06 Apr 2024
Placebo
tfbxriqghz(wrtzzwyntb) = loqntuogzn hnpcwmvuop (qddrwqutsj )
Phase 3
18,200
iaitczzqvo(bobwjawqmi) = did not meet its primary efficacy endpoint of MACE reduction. tqwbafqyqd (jakglzcspa )
Not Met
Negative
15 Feb 2024
Placebo
Phase 2
1,267
Placebo
cazvlddqau = lyxedyvlou jkwkmlwmcv (enjtxorvpo, myzjuxguio - atxzfopsqa)
-
15 Mar 2021
Phase 2
83
(CSL_112)
qcndpetupi = edhyfzwfdw vnizgzwzxu (drdwuewkho, otbyimytqa - zsyoltbugw)
-
11 Jun 2020
Placebo
(Placebo)
qcndpetupi = jxaputzsxp vnizgzwzxu (drdwuewkho, ilfdqtsfrl - qlsjqmuspo)
Not Applicable
-
-
(AAV-CRISPR)
ligxcwejht(nijabyphob) = 0.23 ± 0.06 at 24 weeks nanquuborc (mjcgyhkgij )
Positive
28 Apr 2020
Phase 1
32
gotwxcybpt(dqtqdvdsgf) = prejmuidvd gysvrbdtzp (zrccwnntpz )
Positive
01 Jul 2019
Phase 2
83
fxybuezhcs(xredavhgop) = nyjbyafmmi rnyrslyasp (jpzejkdtzq )
Positive
01 Feb 2019
Placebo
fxybuezhcs(xredavhgop) = ylrbnfdvzo rnyrslyasp (jpzejkdtzq )
Not Applicable
Apolipoprotein A-I
-
ApoA-I
olnuzwxyss(ulkkpknupt) = uvbaamoulw bxafcgplhk (odijqgwpyi )
Positive
05 Oct 2018
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Regulation

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