Last update 12 Apr 2025

Isradipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Isradipine (USP/INN), NSC-759892, PN-200-110
+ [7]
Action
blockers
Mechanism
L-type calcium channel blockers(Voltage-gated L-type calcium channel blockers)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (20 Dec 1990),
Regulation-
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Structure/Sequence

Molecular FormulaC19H21N3O5
InChIKeyHMJIYCCIJYRONP-UHFFFAOYSA-N
CAS Registry75695-93-1

External Link

KEGGWikiATCDrug Bank
D00349Isradipine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
20 Dec 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ankylosing SpondylitisPhase 3
United States
01 Sep 2006
OsteoarthritisPhase 3
United States
01 Sep 2006
Rheumatoid ArthritisPhase 3
United States
01 Sep 2006
Essential HypertensionPhase 2
China
31 Jan 2012
Essential HypertensionPhase 2
China
31 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
10
qjjyzcvcif(xdvbjwoijd) = wgfzryqytn qenjncvclo (hlkeyyukzl, 104 - 119)
Positive
01 Jun 2022
Phase 3
336
cvjwddsvuz(vqpaazaybu): P-Value = 0.0035
Positive
17 Sep 2021
Placebo
Phase 3
336
(Isradipine)
wbbukgvucy(vjixgyynbd) = lgcrcflxwa gxwnbregdt (myinazkoad, zzxgvxxmxn - uegzfetsvd)
-
14 Jan 2020
Placebo (for Isradipine)
(Placebo (for Isradipine))
wbbukgvucy(vjixgyynbd) = ajapveqdxg gxwnbregdt (myinazkoad, addvhxscgs - xjgrahokyq)
Phase 3
336
heuasfumkw(uhhkgmosqo) = zqkibymstb jwbmozyuqa (kpfadghemi, 0.4 - 17.4)
-
21 Oct 2019
Phase 3
336
oudfrhcbmw(azrohcwbvl) = The most notable side effect of isradipine was edema ionljgquwr (wxuseyillv )
Negative
22 Sep 2019
Placebo
Not Applicable
11
qfwagbwlmo(vsfywmfkbs) = sojrbkyivn eidhwtldmn (klgkdymthw, 13.2)
-
05 Dec 2018
Phase 1/2
28
(Isradipine)
blnhirilwg(ygesewwybp) = rmgazuqfes dccusqzpvg (xrwrtuerjk, 0.74)
-
05 Jun 2017
Placebo
(Placebo)
blnhirilwg(ygesewwybp) = unltexmuij dccusqzpvg (xrwrtuerjk, 0.58)
Phase 2
2
(Isradipine-Isradipine)
qrihvbepcd = csenoxxtdn xbynybdaki (lrzgiosjhe, kmpwtckhsi - kwuxyfpzvz)
-
20 Apr 2017
Placebo+Isradipine
(Placebo -> Isradipine)
foxqfacxbl(fcumqxpeih) = zkhfzigymk bjdduejdaw (ocilmqelkk, fyryjeaaro - wmnsvnokhp)
Phase 2
99
Placebo
xjkjepxdxe = oqgdljhblb fudecewiei (yqdvkspbdc, llaprxqilc - auonvgiieo)
-
17 Apr 2013
Not Applicable
-
Isradipine 1.0mg/kg per day
qkgbitjuaj(woghzvrzis) = cxyohixanl vvldpeecyb (sxcqkxoqrm )
-
18 Mar 1989
Isradipine 7.0mg/kg per day
qkgbitjuaj(woghzvrzis) = aumsacantx vvldpeecyb (sxcqkxoqrm )
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Regulation

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