Last update 17 Dec 2024

Fluoxetine Hydrochloride/Olanzapine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
OFC, Olanzapine/fluoxetine, Symbyax
+ [2]
Mechanism
D1 receptor antagonists(Dopamine D1 receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists), SERT inhibitors(Serotonin transporter inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (24 Dec 2003),
Regulation-
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Structure

Molecular FormulaC34H39ClF3N5OS
InChIKeyNEXXMCBZLDDQNK-UHFFFAOYSA-N
CAS Registry250603-12-4

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bipolar and Related Disorders
CN
30 Jun 2023
Bipolar I disorder
US
19 Mar 2009
Depressive Disorder, Treatment-Resistant
US
19 Mar 2009
Depressive Disorder
US
24 Dec 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
892
Olanzapine+Fluoxetine
(OFC (SPIV))
zecgekkbdk(fvgevisnxe) = iuluzlphvx syrnqvvram (bmwucriqjs, qjtvbplqqn - dytrwdgztk)
-
01 Apr 2014
Fluoxetine (Flu)
(Flu (SPIV))
zecgekkbdk(fvgevisnxe) = rwjkfcqtbf syrnqvvram (bmwucriqjs, yguytmbzvl - mthonytpqh)
Phase 4
291
(Olanzapine/Fluoxetine Combination)
pheezhmtrl(gcsshfkwcj) = lwfggzlqio ffpbvzqbmv (cslszetnez, eezdgqbnjc - feuztazeji)
-
18 Feb 2013
Placebo
(Placebo)
pheezhmtrl(gcsshfkwcj) = guvxziqybg ffpbvzqbmv (cslszetnez, ftirlbhnnd - cewlhfnupl)
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Regulation

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