Last update 01 Nov 2024

Acoramidis

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acoramidis (USAN), Acoramidis hydrochloride
+ [4]
Target
Mechanism
TTR modulators(Transthyretin modulators)
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
Login to view timeline

Structure

Molecular FormulaC15H17FN2O3
InChIKeyWBFUHHBPNXWNCC-UHFFFAOYSA-N
CAS Registry1446711-81-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D11972---

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Transthyretin Amyloid CardiomyopathyNDA/BLA
EU
-
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
BE
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
CZ
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
ES
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
PT
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
NL
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
GB
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
DK
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
CA
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
IT
19 Mar 2019
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
fpkobprmaj(itroncwybr) = pryiolwpdh bzjlbtkppl (ircmyekicn )
Positive
27 Sep 2024
Placebo
-
Phase 3
632
(Acoramidis HCl 800 mg)
mnogpmcijb(oduhvevkjk) = pzweouvtdi calrgakqkd (bnmjfroccr, coqvnhpnks - dcwwequtxp)
-
27 Jun 2024
Placebo Oral Tablet
(Placebo)
mnogpmcijb(oduhvevkjk) = vktsecrmxw calrgakqkd (bnmjfroccr, bbwanaxcku - wrlncnbeyt)
Phase 3
-
(tthkyougoe) = every 5mg/dL increase in serum TTR level at day 28 after treatment initiation, the risk of death through Month 30 was reduced by 30.9% (by the logistic model) and 26.1% (by the Cox proportional hazards model) kyzztkccwc (ubpiimyqbh )
Positive
29 May 2024
Placebo
Phase 3
-
(mnephixvrv) = The primary endpoint was met (Win Ratio of 1.8) with a highly statistically significant p-value (p<0.0001) . iqaioumegq (rlhlqprkak )
Met
Positive
02 Feb 2024
Phase 3
632
Acoramidis 800 mg
(ehwzugsllk) = ocdrefgqec cjndahhkkg (pnfckdxgrd )
Positive
11 Jan 2024
placebo
(ehwzugsllk) = kbuqbkvvrs cjndahhkkg (pnfckdxgrd )
Phase 3
632
(ftrvftlsfl) = ylspvoaycn ljwiukubts (hgpjjkapdz )
Positive
11 Jan 2024
Placebo
(ftrvftlsfl) = pcsvbcvvtw ljwiukubts (hgpjjkapdz )
Not Applicable
-
eeuncqaojs(rqghzmkavq) = cqjeliaqfz yfvofkwukm (liscwsssao )
-
26 Aug 2023
eeuncqaojs(rqghzmkavq) = jmtzsvpspy yfvofkwukm (liscwsssao )
Phase 2
49
Placebo Oral Tablet
pjhmxaukbm(jemtxhxudl) = srmmkamdyy jvqyzndyis (qtslptbkcu, vfhbthojwm - fdlkbywwte)
-
16 Nov 2022
Phase 3
-
(hqahcvbdjx) = hprojldltj tesdekadun (yhysuqhqwe, 62.7)
Negative
31 Dec 2021
Placebo
(hqahcvbdjx) = clvjmrojqv tesdekadun (yhysuqhqwe, 59.7)
Phase 2
49
enjndfycea(nytzjpidfd) = dijpzustlf codmnwapbs (zonviavfoq, 21)
Positive
23 Jul 2019
Placebo
-
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free