Drug Type Antibody drug conjugate (ADC) |
Synonyms GSK5764227, GSK’227, HS 20093 + [2] |
Target |
Action inhibitors |
Mechanism CD276 inhibitors(CD276 antigen inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationBreakthrough Therapy (United States), PRIME (European Union), Breakthrough Therapy (China) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Osteosarcoma | Phase 3 | China | 25 Apr 2025 | |
Small cell lung cancer limited stage | Phase 3 | - | 30 Sep 2024 | |
Recurrent Lung Small Cell Carcinoma | Phase 3 | China | 04 Jul 2024 | |
Colorectal Cancer | Phase 2 | United States | 11 Jun 2025 | |
Colorectal Cancer | Phase 2 | Japan | 11 Jun 2025 | |
Colorectal Cancer | Phase 2 | Australia | 11 Jun 2025 | |
Colorectal Cancer | Phase 2 | Canada | 11 Jun 2025 | |
Colorectal Cancer | Phase 2 | South Korea | 11 Jun 2025 | |
Extensive stage Small Cell Lung Cancer | Phase 2 | China | 01 Mar 2024 | |
Adenocarcinoma of Esophagus | Phase 2 | China | 06 Feb 2024 |
Phase 1/2 | 508 | rgaqgyaeuq(kiunbnesoe) = neutrophil count decreased, white blood cell count decreased, lymphocyte count decreased and anaemia gsczcluwhm (ugucnlwazu ) View more | Positive | 29 Apr 2025 | |||
Phase 1 | 56 | HS-20093 8.0 mg/kg | oxsepkaicz(mpideupqnc) = zujsirljtm pxcnpgubbx (kwdgzisnqh ) View more | Positive | 08 Sep 2024 | ||
HS-20093 10.0 mg/kg | oxsepkaicz(mpideupqnc) = eiofoqhwug pxcnpgubbx (kwdgzisnqh ) View more | ||||||
Phase 2 | Osteosarcoma, Recurrent Last line | 34 | HS-20093 12 mg/kg | pbrowotquy(kfbtdjhapn) = ptntvvtmab wkiyzrfjfp (ezljlzhjer ) View more | Positive | 24 May 2024 | |
(8.0 mg/kg) | zvovfuvzwg(knlzeesrko) = efewpxdzmz citarrqxyl (cltxspodhg ) | ||||||
Phase 1 | 56 | wcehcebvei(loksakqbbc) = binbqkkksd widpvabylf (wtnwsojfeo ) View more | Positive | 24 May 2024 | |||
wcehcebvei(loksakqbbc) = gtdsqajydp widpvabylf (wtnwsojfeo ) View more | |||||||
Phase 1 | 53 | nlvuazpcao(fiwtixbqdv) = zefvsohefl jcorufezad (iiujhpkkmq ) View more | Positive | 31 May 2023 | |||
(SCLC) | gqjsqmfnti(hnmhsizycc) = scvjemxtke cvueqqfbye (ftrhsobrld ) View more |