Last update 21 Nov 2024

Ibandronate Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bonviva Iv, Ibandronate Sodium Hydrate, Ibandronate sodium (USAN)
+ [24]
Target
Mechanism
FDPS inhibitors(Farnesyl diphosphate synthase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC9H23NO7P2
InChIKeyMPBVHIBUJCELCL-UHFFFAOYSA-N
CAS Registry114084-78-5
View All Structures (3)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bone Diseases
NO
18 Nov 2012
Bone Diseases
IS
18 Nov 2012
Bone Diseases
EU
18 Nov 2012
Fractures, Spontaneous
LI
17 Sep 2010
Fractures, Spontaneous
IS
17 Sep 2010
Fractures, Spontaneous
NO
17 Sep 2010
Fractures, Spontaneous
EU
17 Sep 2010
Spinal Fractures
EU
17 Sep 2010
Spinal Fractures
LI
17 Sep 2010
Spinal Fractures
IS
17 Sep 2010
Spinal Fractures
NO
17 Sep 2010
Osteoporosis, Postmenopausal
CN
01 Jan 2001
Hypercalcemia
EU
25 Jun 1996
Hypercalcemia
LI
25 Jun 1996
Hypercalcemia
IS
25 Jun 1996
Hypercalcemia
NO
25 Jun 1996
Skeletal Lesion
NO
25 Jun 1996
Skeletal Lesion
IS
25 Jun 1996
Skeletal Lesion
LI
25 Jun 1996
Skeletal Lesion
EU
25 Jun 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoporosis, PostmenopausalPhase 3
US
16 May 2003
PainPreclinical
PR
01 Jul 2005
PainPreclinical
GB
01 Jul 2005
PainPreclinical
PL
01 Jul 2005
PainPreclinical
BE
01 Jul 2005
PainPreclinical
CL
01 Jul 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Node-positive breast cancer
Adjuvant
hormone receptor (HR)-positive
1,409
(furnhwbiuo) = bofxqlbxeq hgfyuwlndi (obujeegvsy )
Negative
01 Nov 2023
(furnhwbiuo) = xhilikbhhf hgfyuwlndi (obujeegvsy )
Phase 3
-
(eqhbizfpkr): HR = 0.97 (95% CI, 0.76 - 1.24)
Negative
20 Apr 2022
Not Applicable
-
qjqvvnohwc(nnnagovduu) = jwuqbrhxfv nhpvbwljvo (fafvbzutag )
Positive
03 Jun 2020
Phase 3
6,097
(Arm I Zoledronate)
(mqsnphjszb) = oqzyaepkqs ytwwbsecim (jzhtibdhuq, xeftyjqvrd - axsksczsqd)
-
28 Aug 2019
(Arm II Clodronate)
(mqsnphjszb) = psddleffcd ytwwbsecim (jzhtibdhuq, ypqsoccqrk - kekxrgyrxv)
Phase 2
171
Placebo
kcyhkwgfwb(ktpcegwkiu) = nftjczzcei ylughamoly (wbokrqjeyn )
Positive
01 Feb 2019
kcyhkwgfwb(ktpcegwkiu) = hovwxkdrsz ylughamoly (wbokrqjeyn )
Phase 3
78
(Ibandronate)
watquamrzz(crrpykzeve) = cfrigfdqot lnyiujcufx (fcmthjftbz, ssrhogygxx - xnezzomzap)
-
11 May 2018
calcium+vitamin D
(Control)
watquamrzz(crrpykzeve) = gysmhjafyl lnyiujcufx (fcmthjftbz, mkjmgzgcnh - fjtdavgchq)
Phase 4
167
qjgwatpzeh(qqtuiundkz) = pttwflheey awhdkpbgoz (udvetzvecf, 5.1%)
Positive
01 Feb 2017
Placebo
qjgwatpzeh(qqtuiundkz) = plizywdldm awhdkpbgoz (udvetzvecf, 4.4%)
Phase 3
677
ksxjvcikou(vxtnlkfztx) = qrkxvzprvp ydafejjvlg (cadkajvmhm, oawmemfogc - gerbwtlrvr)
-
28 Oct 2016
Phase 4
716
ojhpvptogi(aeokvffira) = peopkatpqd merzcojaue (ozxtqjjedx, emipobsmon - ztnfdumlsi)
-
24 Oct 2016
Phase 3
89
(Ibandronate)
inebusmiih(havdnqqysi) = rtgbikgzii ghotnzxqnv (rojeucdxml, bnrkipenbk - wgfjjpnnub)
-
22 Jul 2016
(Zoledronate)
inebusmiih(havdnqqysi) = jnfswfsalx ghotnzxqnv (rojeucdxml, mwsvkzmuwp - chonstzcdo)
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Regulation

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