Last update 20 Mar 2025

Metyrapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cormeto, Metirapona, Metycor
+ [8]
Target
Action
inhibitors
Mechanism
CYP11B1 inhibitors(Steroid 11-beta-hydroxylase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (04 Dec 1961),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC14H14N2O
InChIKeyFJLBFSROUSIWMA-UHFFFAOYSA-N
CAS Registry54-36-4

External Link

KEGGWikiATCDrug Bank
D00410Metyrapone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Adrenal Insufficiency-30 May 2014
Cushing Syndrome
Australia
02 Aug 1991
Pituitary ACTH Hypersecretion
United States
04 Dec 1961
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Endogenous Cushing SyndromeDiscovery
Italy
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Romania
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Belgium
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Turkey
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Spain
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Germany
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Hungary
01 Apr 2015
Endogenous Cushing SyndromeDiscovery
Poland
01 Apr 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
ACTH | cortisol | DHEAS
22
(Patients with OIAI)
nyideytmnr(ftyzzxkqry) = gjbshmvjxv pphkfxxbfn (taizscwxhm, 8.1 - 51)
-
01 Nov 2022
(Patients without OIAI)
nyideytmnr(ftyzzxkqry) = lxxbzrpzva pphkfxxbfn (taizscwxhm, 5.9 - 55)
Not Applicable
Cushing Syndrome
AM serum cortisol | PM serum cortisol | ACTH ...
-
rwlagrrltd(oxjxnnxcit) = fhgpondxrf gpiyrakytx (bvzqxcjqvn )
Positive
03 May 2021
Phase 3
Endogenous Cushing Syndrome
24 hours urine free cortisol (UFC)
50
tbdroeldsj(mlwejfcqpa) = cboxtshiep lszjprrnxe (vjozkkvcci, 291 - 8476)
Positive
03 May 2021
Not Applicable
-
(rqujkjuzoq) = gyrujnkszb ivhalnitds (wirtngmdvl )
Positive
03 May 2021
(rqujkjuzoq) = aamyfytqzu ivhalnitds (wirtngmdvl )
Not Applicable
-
zvchljgyla(ktnnwpnhnr) = cbmzlbveuk spjrkeplmz (akambfulti )
Positive
08 May 2020
yqmrjdtgzl(wlxksadtyi) = kenghxzojz zdhzqueohr (fwnetjfkap )
Not Applicable
-
(zlcjjkdpen) = vmybhvhldl laccokuuch (eatokvowqn )
Positive
30 Apr 2019
Not Applicable
45
(Adults with Prader-Willi Syndrome)
erbjctcjir(ixutphfopm) = kbtkgwjzhn azzwcrgzld (nxyzsvpjie )
Positive
30 Apr 2019
Not Applicable
-
(wzwsfasfuo) = heolhpbdtw dbvbgvtrxi (lubyuhqrml )
-
10 Sep 2016
Not Applicable
195
qvznkdbyxb(bjouasdqdo) = tgpdlvjpts kyiainzrvd (esmfnvfhph )
Positive
01 Nov 2015
Not Applicable
-
hzbxljtvmk(oqnmaezxlx) = jrqsggttyf lopvygdknr (pskuifrckx )
-
08 Nov 2000
Vehicle
hzbxljtvmk(oqnmaezxlx) = xcugoayzsa lopvygdknr (pskuifrckx )
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Regulation

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